Patents by Inventor Alexander Iain McIntosh

Alexander Iain McIntosh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for extracting mass information from low resolution mass-to-charge ratio spectra of multiply charged species
    Patent number: 10297434
    Abstract: An apparatus and method for extracting mass information from low resolution mass-to-charge ratio spectra of multiply charged species is described. Curve fitting is performed using the logarithm of the mass to charge data, which deemphasizes noise induced disturbances.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: May 21, 2019
    Assignee: Microsaic Systems PLC
    Inventor: Alexander Iain McIntosh
  • A Method for Extracting Mass Information from Low Resolution Mass-to-Charge Ratio Spectra of Multiply Charged Species
    Publication number: 20190103259
    Abstract: An apparatus and method for extracting mass information from low resolution mass-to-charge ratio spectra of multiply charged species is described. Curve fitting is performed using the logarithm of the mass to charge data, which deemphasizes noise induced disturbances.
    Type: Application
    Filed: April 25, 2017
    Publication date: April 4, 2019
    Applicant: Microsaic Systems PLC
    Inventor: Alexander Iain McIntosh
  • Method and system for monitoring biomolecule separations by mass spectrometry
    Patent number: 9535042
    Abstract: Monitoring biomolecule separations by mass spectrometry is described. The mixture to be separated is introduced into a first fluidic stream, which then passes through a chromatography column. Small samples are periodically taken from the first fluidic stream as it leaves the chromatography column and injected into a first branch of a second fluidic stream. Low molecular weight components detrimental to the efficient operation of the mass spectrometer are removed by an in-line dialysis cell. A second fraction of the second fluidic stream acts as the dialysate. In a second and preferred system provided in accordance with the present teaching, the first fraction of the second fluidic stream is further split downstream of the sampling mechanism through the use of a three-way connector. Approximately 0.3 to 5 microliters per minute continues through the dialysis cell and thereafter to the electrospray emitter of the mass spectrometer.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: January 3, 2017
    Assignee: MICROSAIC SYSTEMS PLC
    Inventors: Steven Wright, Alexander Iain McIntosh
  • Method and System for Monitoring Biomolecule Separations by Mass Spectrometry
    Publication number: 20160003787
    Abstract: Monitoring biomolecule separations by mass spectrometry is described. The mixture to be separated is introduced into a first fluidic stream, which then passes through a chromatography column. Small samples are periodically taken from the first fluidic stream as it leaves the chromatography column and injected into a first branch of a second fluidic stream. Low molecular weight components detrimental to the efficient operation of the mass spectrometer are removed by an in-line dialysis cell. A second fraction of the second fluidic stream acts as the dialysate. In a second and preferred system provided in accordance with the present teaching, the first fraction of the second fluidic stream is further split downstream of the sampling mechanism through the use of a three-way connector. Approximately 0.3 to 5 microliters per minute continues through the dialysis cell and thereafter to the electrospray emitter of the mass spectrometer.
    Type: Application
    Filed: July 1, 2015
    Publication date: January 7, 2016
    Inventors: Steven Wright, Alexander Iain McIntosh