Patents by Inventor Alexander J. MacLennan

Alexander J. MacLennan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Molecular cloning and expression of G-protein coupled receptors
    Patent number: 5585476
    Abstract: The cloning and expression of two novel rat cDNAs "H218" and "rat-edg") which encode two members ("p.sup.H218 " and "p.sup.rat-edg ") of the G-protein coupled receptor superfamily of proteins is described. The amino acid sequence similarity between "p.sup.H218 " and "p.sup.rat-edg " suggests that they may be activated by the same endogenous ligand(s). The expression pattern of mRNA transcripts of both genes in cell lines, various rat tissues and developing rat brain suggests that they both play a role in cell proliferation and/or differentiation. The polynucleotide molecules, proteins, and antibodies of the subject invention can be used in both diagnostic and therapeutic applications.
    Type: Grant
    Filed: February 15, 1994
    Date of Patent: December 17, 1996
    Inventor: Alexander J. MacLennan