Patents by Inventor Alexander J. Travis
Alexander J. Travis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230304997Abstract: This disclosure provides a method for determining male fertility status. The method comprises determining GM1 distribution patterns following induced sperm capacitation, identifying the frequency of distribution of various patterns, and determining if the frequency distribution of certain GM1 patterns in response to induced capacitation is altered. Based on the change in the frequency distribution patterns of certain patterns in response to induced capacitation, alone or in combination with other sperm attributes, male fertility status can be identified.Type: ApplicationFiled: May 26, 2023Publication date: September 28, 2023Inventors: Alexander J. TRAVIS, Gianpiero PALERMO
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Publication number: 20230296627Abstract: The present invention relates to methods of detecting a neural injury biomarker in a biological sample. The method includes subjecting a biological sample to an assay according to the present invention that produces a measurable signal and detecting the measurable signal. The presence or absence of the measurable signal indicates the presence or absence of the biomarker in the sample. The present invention also relates to methods of determining the state of a subject's neural injury. The present invention also relates to systems and devices useful in carrying out the methods of the present invention.Type: ApplicationFiled: October 21, 2022Publication date: September 21, 2023Inventors: Alexander J.A. TRAVIS, Roy COHEN
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Patent number: 11698368Abstract: This disclosure provides a method for determining male fertility status. The method comprises determining GM1 distribution patterns following induced sperm capacitation, identifying the frequency of distribution of various patterns, and determining if the frequency distribution of certain GM1 patterns in response to induced capacitation is altered. Based on the change in the frequency distribution patterns of certain patterns in response to induced capacitation, alone or in combination with other sperm attributes, male fertility status can be identified.Type: GrantFiled: September 16, 2015Date of Patent: July 11, 2023Assignee: Cornell UniversityInventors: Alexander J. Travis, Gianpiero Palermo
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Patent number: 11549953Abstract: The present invention relates to methods of detecting a neural injury biomarker in a biological sample. The method includes subjecting a biological sample to an assay according to the present invention that produces a measurable signal and detecting the measurable signal. The presence or absence of the measurable signal indicates the presence or absence of the biomarker in the sample. The present invention also relates to methods of determining the state of a subject's neural injury. The present invention also relates to systems and devices useful in carrying out the methods of the present invention.Type: GrantFiled: December 8, 2016Date of Patent: January 10, 2023Assignee: CORNELL UNIVERSITYInventors: Alexander J. A. Travis, Roy Cohen
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Publication number: 20210241855Abstract: This disclosure provides a method for determining male fertility status, and its relationship to the probability of generating a pregnancy as calculated using a regression model. The method comprises determining GM1 localization patterns following induced sperm capacitation, identifying the percentage of various patterns, particularly the ratio of [(AA+APM)/total number of GM1 localization patterns] and determining if the percentage of certain GMI localization patterns in response to induced capacitation is altered. Based on the change in the percentage of localization patterns of certain patterns in response to induced capacitation, alone or in combination with other sperm attributes, male fertility status can be identified.Type: ApplicationFiled: May 2, 2019Publication date: August 5, 2021Applicant: ANDROVIA LIFESCIENCES, LLCInventors: Alexander J. TRAVIS, John D. COOK
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Publication number: 20200116707Abstract: This disclosure provides a method for determining male fertility status. The method comprises determining GM1 localization patterns following induced sperm capacitation, identifying the percentage of various patterns, particularly the ratio of [(AA+APM)/total number of GM1 localization patterns] and determining if the percentage of certain GM1 localization patterns in response to induced capacitation is altered. Based on the change in the percentage of localization patterns of certain patterns in response to induced capacitation, alone or in combination with other sperm attributes, male fertility status can be identified.Type: ApplicationFiled: December 13, 2019Publication date: April 16, 2020Applicant: Androvia LifeSciences, LLCInventors: Alexander J. Travis, Cristina Cardona, Melissa A. Moody, Alana J. Simpson, G. Charles Ostermeier
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Patent number: 10539555Abstract: This disclosure provides a method for determining male fertility status. The method comprises determining GM1 localization patterns following induced sperm capacitation, identifying the percentage of various patterns, particularly the ratio of [(AA+APM)/total number of GM1 localization patterns] and determining if the percentage of certain GM1 localization patterns in response to induced capacitation is altered. Based on the change in the percentage of localization patterns of certain patterns in response to induced capacitation, alone or in combination with other sperm attributes, male fertility status can be identified.Type: GrantFiled: February 17, 2017Date of Patent: January 21, 2020Assignee: ANDROVIA LIFESCIENCES, LLCInventors: Alexander J. Travis, Cristina Cardona, Melissa A. Moody, Alana J. Simpson, G. Charles Ostermeier
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Publication number: 20170248584Abstract: This disclosure provides a method for determining male fertility status. The method comprises determining GM1 distribution patterns following induced sperm capacitation, identifying the frequency of distribution of various patterns, and determining if the frequency distribution of certain GM1 patterns in response to induced capacitation is altered. Based on the change in the frequency distribution patterns of certain patterns in response to induced capacitation, alone or in combination with other sperm attributes, male fertility status can be identified.Type: ApplicationFiled: September 16, 2015Publication date: August 31, 2017Applicant: Cornell UniversityInventors: Alexander J. TRAVIS, Gianpiero PALERMO
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Publication number: 20170234857Abstract: This disclosure provides a method for determining male fertility status. The method comprises determining GM1 localization patterns following induced sperm capacitation, identifying the percentage of various patterns, particularly the ratio of [(AA+APM)/total number of GM1 localization patterns] and determining if the percentage of certain GM1 localization patterns in response to induced capacitation is altered. Based on the change in the percentage of localization patterns of certain patterns in response to induced capacitation, alone or in combination with other sperm attributes, male fertility status can be identified.Type: ApplicationFiled: February 17, 2017Publication date: August 17, 2017Inventors: Alexander J. Travis, Cristina Cardona, Melissa A. Moody, Alana J. Simpson, G. Charles Ostermeier
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Publication number: 20170184605Abstract: The diagnosis of male infertility is based predominantly on the results of standard semen analysis for concentration, total motility, progressive motility, volume, pH, viscosity and/or morphology. When sperm enter the female reproductive tract, they must undergo a series of physiological changes, known as capacitation, in order to fertilize an egg. This process involves plasma membrane changes that occur in response to stimuli within the female tract. These changes include removal of sterols and redistribution of the ganglioside GM1. Semen analysis identifies only half the cases of male infertility due to standard semen analysis providing little information on sperm functional competence. Previous data demonstrated that localization of the ganglioside, GM1, identifies sub-populations of sperm capable of undergoing the functional maturation process known as capacitation and tracks strongly with fertility.Type: ApplicationFiled: December 22, 2016Publication date: June 29, 2017Inventors: Alexander J. TRAVIS, Cristina CARDONA, Melissa A. MOODY, Alana J. SIMPSON, G. Charles OSTERMEIER
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Publication number: 20170089926Abstract: The present invention relates to methods of detecting a neural injury biomarker in a biological sample. The method includes subjecting a biological sample to an assay according to the present invention that produces a measurable signal and detecting the measurable signal. The presence or absence of the measurable signal indicates the presence or absence of the biomarker in the sample. The present invention also relates to methods of determining the state of a subject's neural injury. The present invention also relates to systems and devices useful in carrying out the methods of the present invention.Type: ApplicationFiled: December 8, 2016Publication date: March 30, 2017Inventors: Alexander J.A. TRAVIS, Roy COHEN
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Patent number: 9547014Abstract: The disclosure relates to methods of detecting a neural injury biomarker in a biological sample. The method includes subjecting a biological sample to an assay disclosed that produces a measurable signal and detecting the measurable signal. The presence or absence of the measurable signal indicates the presence or absence of the neural injury biomarker in the sample, and thereby diagnosing a subject as having a neural injury. The disclosure further relates to methods of determining the state of a subject's neural injury. Further disclosed are systems and devices useful in carrying out the methods disclosed.Type: GrantFiled: June 11, 2012Date of Patent: January 17, 2017Assignee: Cornell UniversityInventors: Alexander J. A. Travis, Roy Cohen
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Publication number: 20150118218Abstract: The disclosure relates to methods of detecting a neural injury biomarker in a biological sample. The method includes subjecting a biological sample to an assay disclosed that produces a measurable signal and detecting the measurable signal. The presence or absence of the measurable signal indicates the presence or absence of the neural injury biomarker in the sample, and thereby diagnosing a subject as having a neural injury. The disclosure further relates to methods of determining the state of a subject's neural injury. Further disclosed are systems and devices useful in carrying out the methods disclosed.Type: ApplicationFiled: June 11, 2012Publication date: April 30, 2015Applicant: CORNELL UNIVERSITYInventors: Alexander J.A. Travis, Roy Cohen
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Patent number: 8367313Abstract: This invention describes unique patterns of distribution of ganglioside GM1 in non-capacitated sperm and demonstrates that the pattern of distribution of GM1 undergoes changes that can be correlated with the process of capacitation and/or with acrosomal exocytosis. Accordingly, the present invention discloses a method for determining the ability of sperm to respond to capacitation and/or acrosomal exocytosis stimuli. The method comprises determination of distribution pattern for GM1. The method can be used for both diagnostic and predictive purposes when assessing male reproductive fitness, and can also be used to assess the effects of any agent or environment on sperm including cryoprotective agents and protocols, and contraceptive agents.Type: GrantFiled: March 1, 2010Date of Patent: February 5, 2013Assignees: Cornell University, Trustees of the University of PennsylvaniaInventors: Alexander J. Travis, Gregory S. Kopf
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Publication number: 20100248302Abstract: This invention describes unique patterns of distribution of ganglioside GM1 in non-capacitated sperm and demonstrates that the pattern of distribution of GM1 undergoes changes that can be correlated with the process of capacitation and/or with acrosomal exocytosis. Accordingly, the present invention discloses a method for determining the ability of sperm to respond to capacitation and/or acrosomal exocytosis stimuli. The method comprises determination of distribution pattern for GM1. The method can be used for both diagnostic and predictive purposes when assessing male reproductive fitness, and can also be used to assess the effects of any agent or environment on sperm including cryoprotective agents and protocols, and contraceptive agents.Type: ApplicationFiled: March 1, 2010Publication date: September 30, 2010Inventors: Alexander J. Travis, Gregory S. Kopf
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Patent number: 7670763Abstract: This invention describes unique patterns of distribution of ganglioside GM1 in non-capacitated sperm and demonstrates that the pattern of distribution of GM1 undergoes changes that can be correlated with the process of capacitation and/or with acrosomal exocytosis. Accordingly, the present invention discloses a method for determining the ability of sperm to respond to capacitation and/or acrosomal exocytosis stimuli. The method comprises determination of distribution pattern for GM1. The method can be used for both diagnostic and predictive purposes when assessing male reproductive fitness, and can also be used to assess the effects on sperm of cryoprotective agents and protocols, and contraceptive agents.Type: GrantFiled: November 1, 2006Date of Patent: March 2, 2010Assignees: Cornell Research Foundation, Inc., Trustees of the University of PennsylvaniaInventors: Alexander J. Travis, Gregory S. Kopf
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Patent number: 7160676Abstract: This invention describes unique patterns of distribution of ganglioside GM1 in non-capacitated sperm and demonstrates that the pattern of distribution of GM1 undergoes changes that can be correlated with the process of capacitation and/or with acrosomal exocytosis. Accordingly, the present invention discloses a method for determining the ability of sperm to respond to capacitation and/or acrosomal exocytosis stimuli. The method comprises determination of distribution pattern for GM1. The method can be used for both diagnostic and predictive purposes when assessing male reproductive fitness, and can also be used to assess the effects on sperm of cryoprotective agents and protocols, and contraceptive agents.Type: GrantFiled: July 23, 2004Date of Patent: January 9, 2007Assignees: Cornell Research Foundation, Inc., Trustees of the University of PennsylvaniaInventors: Alexander J. Travis, Gregory S. Kopf