Abstract: Devices and methods for delivering a substance to tissue or organs, particularly, the bladder, by a plurality of microneedles The devices may include a delivery tube, a a substance chamber to fill with the substance to be delivered, a plurality of needles, a plunger coupled to a handle movable relative to the tube to deliver the substance to the tissue through the needles, and a protective plate having at least one orifice therein, such that when the device is in a first, resting, position the needle tips are on a first side of the protective plate, and when the device is in a second, operational, position, the needles are on a second side of the protective plate.

Abstract: This invention relates to the area of medical technique and, particularly, to orthopedic devices. The proposed device intended to perform reduction of a vertebra by elevation of the pressure in the abdominal cavity this pressure brings the vertebra into its anatomically correct position. As a result, such device allows to treat spodylolysis and spondylolisthesis without surgical intervention.