Abstract: The method for increasing contractility in patients with systolic heart failure involves screening for candidate small molecules which block the interaction between Rad and the plasma membrane and/or block the interaction between Rad and the CaV1.2/CaV?2 complex, or between Rad and CaV?2, in order to increase cardiac contractility. A method for preventing calcium overload and arrhythmias in heart disease involves preventing the dissociation of Rad and the CaV1.2/CaV?2 complex, or between Rad and CaV?2, during beta-adrenergic system activation. Additionally, a method of screening for drugs that block interaction between an RGK GTPase protein and a ?-subunit of the calcium channel is provided. A suitable technique, such as fluorescence resonance energy transfer (FRET), may be used to assess blocking of the interaction between the RGK GTPase protein and the ?-subunit of the calcium channel for the treatment of heart disease, pain, diabetes, skeletal muscle disorders and/or central nervous system (CNS) disorders.

Abstract: The present invention provides, inter alia, methods for identifying a candidate agent that can treat or ameliorate the effects of a heart condition caused by the effects of abnormal beta-adrenergic receptor activation on calcium levels in cardiomyocytes in a subject. Compositions that include the candidate agents identified by the methods disclosed, and methods of treating or ameliorating the effects of a heart condition in a subject by administering to the subject the candidate agents identified by the methods disclosed, are also provided.

Abstract: The present invention provides, inter alia, methods for identifying a candidate agent that can treat or ameliorate the effects of a heart condition caused by the effects of abnormal beta-adrenergic receptor activation on calcium levels in cardiomyocytes in a subject. Compositions that include the candidate agents identified by the methods disclosed, and methods of treating or ameliorating the effects of a heart condition in a subject by administering to the subject the candidate agents identified by the methods disclosed, are also provided.

Abstract: Fluid monitoring devices and/or systems are provided for monitoring fluid output, including volume and flow rate. A high resolution, low cost electronic fluid monitoring device and system collects fluid such as urine and includes a force sensor that correlates the force of gravity on a fluid collection container with strain and converts it to electrical energy. The force registered on the sensor is correlated with fluid content using a pre-programmed machine learning based algorithm and can be used to identify fluid volume and flow rate. Vertical adjustment and rotational adjustment systems for the device are also described.

Abstract: A predictive modeling system having a marketability service module and a career path module. The marketability service module of the system server employs a marketability algorithm to determine how marketable a user is based on self-reported work experience and skills for a job. The career path module employs a career path algorithm to provide to the user a prediction of a most successful path from a users current position to a destination position on the basis of a career paths database of transitions provided by a career path analyzer of a batch computing platform intermittently in communication with the career paths database.