Patents by Inventor Alexander Mark Gibson

Alexander Mark Gibson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluorination process
    Patent number: 9468694
    Abstract: The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, —(CH2CH2O)q—CH3 wherein q is an integer of from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: October 18, 2016
    Assignee: GE Healthcare Limited
    Inventors: Anthony Eamon Storey, Clare Louise Jones, Denis Raymond Christophe Bouvet, Nicolas Lasbistes, Steven Michael Fairway, Lorenzo Williams, Alexander Mark Gibson, Robert James Nairne, Farhad Karimi, Bengt Langstrom
  • Fluorination Process
    Publication number: 20150328344
    Abstract: The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, —(CH2CH2O)q—CH3 wherein q is an integer of from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.
    Type: Application
    Filed: July 27, 2015
    Publication date: November 19, 2015
    Applicants: GE HEALTHCARE AS, GE HEALTHCARE LIMITED
    Inventors: Anthony Eamon Storey, Clare Louise Jones, Denis Raymond Christophe Bouvet, Nicolas Lasbistes, Steven Michael Fairway, Lorenzo Williams, Alexander Mark Gibson, Robert James Nairne, Farhad Karimi, Bengt Langstrom
  • Fluorination process
    Patent number: 9126961
    Abstract: The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, —(CH2CH2O)q—CH3 wherein q is an integer of from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: September 8, 2015
    Assignees: GE Healthcare Limited, GE Healthcare AS
    Inventors: Anthony Eamon Storey, Clare Louise Jones, Denis Raymond Christophe Bouvet, Nicholas Lasbistes, Steven Michael Fairway, Lorenzo Williams, Alexander Mark Gibson, Robert James Nairne, Farhad Karimi, Bengt Langstrom
  • Fluorination process of anilide derivatives and benzothiazole fluorinate derivatives as in vivo imaging agents
    Patent number: 8410312
    Abstract: The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, —(CH2CH2O)q—CH3 wherein q is an integer of from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: April 2, 2013
    Assignees: GE Healthcare Limited, GE Healthcare AS
    Inventors: Anthony Eamon Storey, Clare Louise Jones, Denis Raymond Christophe Bouvet, Nicolas Lasbistes, Steven Michael Fairway, Lorenzo Williams, Alexander Mark Gibson, Robert James Nairne, Farhad Karimi, Bengt Langstrom
  • Solid-phase fluorination of benzothiazoles
    Patent number: 8323616
    Abstract: The invention provides a process for the production of an 18F-labelled tracer which comprises treatment of a solid support-bound precursor of formula (I) SOLID SUPPORT-LINKER-X-TRACER (I) wherein X is a group which promotes nucleophilic substitution at a specific site on the attached TRACER and the TRACER is of formula (A).
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: December 4, 2012
    Assignees: GE Healthcare Limited, Hammersmith Imanet Limited
    Inventors: Frank Brady, Sajinder Kaur Luthra, Alexander Mark Gibson
  • PURIFICATION METHODS
    Publication number: 20120275973
    Abstract: The invention relates to novel processes for the purification of radiolabelled tracers, using a solid-support bound scavenger group.
    Type: Application
    Filed: July 12, 2012
    Publication date: November 1, 2012
    Applicants: HAMMERSMITH IMANET LIMITED, GE HEALTHCARE AS, GE HEALTHCARE LIMITED
    Inventors: SAJINDER KAUR LUTHRA, FRANK BRADY, NICHOLAS TOBY JEFFERY, ERIK ARSTAD, ALEXANDER MARK GIBSON, DUNCAN WYNN, ALAN CUTHBERTSON, MAGNE SOLBAKKEN
  • Purification methods
    Patent number: 8221720
    Abstract: The invention relates to novel processes for the purification of radiolabelled tracers, using a solid-support bound scavenger group.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: July 17, 2012
    Assignees: Hammersmith Imanet Limited, GE Healthcare Limited, GE Healthcare AS
    Inventors: Sajinder Kaur Luthra, Frank Brady, Nicholas Toby Jeffery, Erik Arstad, Alexander Mark Gibson, Duncan Wynn, Alan Cuthbertson, Magne Solbakken
  • Fluorination Process of Anilide Derivatives and Benzothiazole Fluorinate Derivatives as in VIVO Imaging Agents
    Publication number: 20100234611
    Abstract: The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, —(CH2CH2O)q—CH3 wherein q is an integer of from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.
    Type: Application
    Filed: August 11, 2006
    Publication date: September 16, 2010
    Applicants: GE HEALTHCARE LIMITED, GE HEALTHCARE AS
    Inventors: Anthony Eamon Storey, Clare Louise Jones, Denis Raymond Christophe Bouvet, Nicolas Lasbistes, Steven Michael Fairway, Lorenzo Williams, Alexander Mark Gibson, Robert James Nairne, Farhad Karimi, Bengt Langstrom
  • Caspase-3 Substrate Comprising Imaging Agents
    Publication number: 20080286201
    Abstract: The present invention relates to diagnostic imaging agents for in vivo imaging. The imaging agents comprise a synthetic caspase-3 substrate peptide labelled with an imaging moiety suitable for diagnostic imaging in vivo. The invention also provides radiopharmaceutical compositions comprising the imaging agents, together with kits for the preparation of the radiopharmaceuticals. Also described are non-radioactive precursors suitable for the preparation of the imaging agents. The imaging agents are useful for the diagnostic imaging and or therapy monitoring in vivo of various disease states where caspase-3 is involved.
    Type: Application
    Filed: February 3, 2006
    Publication date: November 20, 2008
    Inventors: Benedicte Guilbert, Sue Champion, Alexander Mark Gibson, Sally-Anne Ricketts, Michelle Avory, Bente E. Arbo
  • Solid phase preparation of F-labelled amino acids
    Patent number: 7264792
    Abstract: A process for the production of an 18F-labelled tracer which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO2—O-TRACER (I) with 18F— to produce the labelled tracer of formula (II)
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: September 4, 2007
    Assignee: GE Healthcare Limited
    Inventors: Alexander Mark Gibson, Lynda Jane Brown, Richard Charles Downie Brown
  • Solid-phase nucleophilic fluorination
    Publication number: 20040236085
    Abstract: The present invention relates to novel solid-phase processes for the production of radiolabelled tracers, in particular for the production of 18F-labelled compounds which may be suitable for use as Positron Emission Tomography (PET) radiotracers. The invention also comprises radiopharmaceutical kits using these novel processes.
    Type: Application
    Filed: July 15, 2004
    Publication date: November 25, 2004
    Inventors: Sajinder Kaur Luthra, Frank Brady, Harry John Wadsworth, Alexander Mark Gibson, Matthias Eberhard Glaser
  • Radiolabelled bisphosphonates and method
    Patent number: 6534488
    Abstract: The present invention relates to 32P or 33P-labelled bisphosphonates as radiotherapeutic radiopharmaceuticals. The 32P- or 33P-labelled bisphosphonates, which are chemically identical to the unlabelled agent, are expected to target the lesion site in an identical manner, but also deliver a significant radiocytotoxic effect to the surrounding cells. This should result, given the favorable energetics of the &bgr; particle emission from the 33P nuclide, in a loss of proliferative capacity of cells associated with the tumor lesion. The relative stability and in vivo localisation of bisphosphonates makes them good candidates as 32P/33P delivery vehicles.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: March 18, 2003
    Assignee: Amersham plc
    Inventors: Alexander Mark Gibson, Marivi Mendizabal, Richard Pither, Shirley Elizabeth Pullan, Vaughan Griffiths, Philip Duncanson