Abstract: A method for preparing corneal tissue for applications predominantly in transplantation, and to the use of a solution for decellularizing corneal tissue.

Abstract: The present invention relates to a method for preparing corneal tissue for applications predominantly in transplantation, and to the use of a solution for decellularizing corneal tissue.

Abstract: A method forms an implant with a base body made of a biocorrodible magnesium alloy. The methods make magnesium alloy that contains a plurality of statistically distributed particles, with one or more of the elements Y, Zr, Mn, Sc, Fe, Ni, Co, W, Pt and noble earths with the atomic numbers 57 to 71, or the particles comprise alloys or compounds containing one or more of the elements mentioned. The mean distance of the particles from each other is smaller than the hundredfold mean particle diameter.

Abstract: One embodiment of the invention relates to an implant comprising a base body made of a biocorrodible magnesium alloy. The magnesium alloy contains a plurality of statistically distributed particles, comprising one or more of the elements Y, Zr, Mn, Sc, Fe, Ni, Co, W, Pt and noble earths with the atomic numbers 57 to 71, or the particles comprise alloys or compounds containing one or more of the elements mentioned. The mean distance of the particles from each other is smaller than the hundredfold mean particle diameter.

Abstract: A method for preparing tissue, in particular pericardial tissue, in particular for use as a sealing means for a heart valve prosthesis for paravalvular leaks, characterised in that the tissue, in particular pericardial tissue, is decellularized (4), subjected to a cross-linking (6) with a glutaraldehyde-containing solution, and subjected to a shape- and a structure-stabilising step (7, 8, 9). The invention also relates to a heart valve prosthesis.

Abstract: A method for impressing a 3D shape onto a biological tissue, in particular pericardial tissue, during the cross-linking of the tissue, by use of a mold which has a first 3D contact face for laminar contact against an upper side of the tissue and a second 3D contact face for laminar contact against an rear side of the tissue, wherein the tissue is arranged between the two contact faces so that it lies on both sides thereagainst and at the same time is cross-linked by means of a cross-linking agent so that the cross-linked tissue has a 3D shape after removal from the mold. The invention also relates to an implant comprising such a tissue.

Abstract: A method for preparing tissue for medical applications, in particular for preparing tissue for use for an artificial heart valve using an ?-galactosidase.

Abstract: A method for preparing tissue for medical applications, including decellularizing the tissue by means of a detergent, characterized in that the decellularizing detergent contains at least one amphiphilic lipopeptide; treating the decellularized tissue with an ?-galactosidase; and cross-linking the collagen fibers of the treated tissue by means of a suitable cross-linking agent.

Abstract: The invention relates to an implant comprising an active-agent-containing coating which covers the implant at least in sections. The coating is composed of at least two subsections; a first subsection contains the at least one active substance, and a second subsection contains an auxiliary agent.

Abstract: A method for preparing tissue for medical applications, in particular tissue for use for an artificial heart valve, wherein the method has the steps of decellularizing the tissue by means of a detergent and subsequently cross-linking the collagen fibers of the tissue by means of a suitable cross-linking agent. At least one lipopeptide, such as surfactin, for example, is used as the detergent for decellularization.

Abstract: An aluminum electrolytic capacitor including an anode electrode, and a method for producing the anode electrode. The method includes providing an aluminum electrolyte including an ionic liquid and an aluminum salt, galvanically deposing an aluminum on an aluminum foil formed from the aluminum electrolyte, and anodically oxidizing a surface of the aluminum foil. The ionic liquid includes a pyrrolidinium cation and a halogenide. The aluminum electrolyte includes 50-70 mol. % of the aluminum salt based on a total substance amount of the ionic liquid and the aluminum salt. The galvanic deposition includes and is based on a deposition temperature ranging from 20° C. to 100° C., a current density ranging from 1 to 100 mA/cm2, an applied potential ranging from ?0.1 V to ?1.0 V based on a potential of an aluminum reference electrode, and a deposition rate ranging from 1 to 50 ?m/h.

Abstract: A method of preparing biological tissue for use as a component of an implant, in particular as part of a heart valve prosthesis, which can be implanted by catheter. The biological tissue is subjected to a dimensional and structural stabilization step and is dried. For the dimensional and structural stabilization, a combination of a first, polyethylene glycol-containing solution and at least one second, glycerol-containing solution is used.

Abstract: The present invention refers to an implant with a surface layer having a topographic modification. The topographic modification includes a line pattern with ridge and groove widths of 0.9 to 1.1 ?m and a ridge height of more than 0.9 ?m.

Abstract: The invention relates to an implantation device (10a-d) comprising at least one medical implant (12a-d) and at least one implantation aid (14a-d) comprising at least one expansion element (16a-d). It is provided that the expansion element (16a-d) can be inserted into at least one cavity (18a-d) of the implant (12a-d), and the at least one cavity (18a-d) can be expanded using the expansion element (16a-d), and, in the end state, the expansion element (16a-d) is disposed at least partially in the at least one cavity (18a-d), wherein the expansion element (16a-d) is designed as a solid body (20a-d).

Abstract: An aluminum electrolytic capacitor including an anode electrode, and a method for producing the anode electrode. The method includes providing an aluminum electrolyte including an ionic liquid and an aluminum salt, galvanically deposing an aluminum on an aluminum foil formed from the aluminum electrolyte, and anodically oxidizing a surface of the aluminum foil. The ionic liquid includes a pyrrolidinium cation and a halogenide. The aluminum electrolyte includes 50-70 mol. % of the aluminum salt based on a total substance amount of the ionic liquid and the aluminum salt. The galvanic deposition includes and is based on a deposition temperature ranging from 20° C. to 100° C., a current density ranging from 1 to 100 mA/cm2, an applied potential ranging from ?0.1V to ?1.0 V based on a potential of an aluminum reference electrode, and a deposition rate ranging from 1 to 50 ?m/h.

Abstract: A method for preparing tissue for medical applications, in particular tissue for use for an artificial heart valve, wherein the method has the steps of decellularizing the tissue by means of a detergent and subsequently cross-linking the collagen fibers of the tissue by means of a suitable cross-linking agent. At least one lipopeptide, such as surfactin, for example, is used as the detergent for decellularization.

Abstract: A method for producing an implant, particularly an intraluminal endoprosthesis, having a body, wherein the body comprises magnesium or a magnesium alloy. In order to control the degradation in a desired time window, such as between four weeks and six months, the following production method is carried out: a) preparing the implant body, b) applying a metallic coating onto at least a portion of the body surface, the primary constituent of the coating being at least one element of the group containing titanium and aluminum, c) plasmachemical treatment of the portion of the body surface provided with the coating in an aqueous solution in order to produce a layer created by plasmachemical treatment by applying a mixed voltage generating the plasma to the body of the implant, wherein the mixed voltage has sufficient energy to temporarily ionize both the metallic coating and a subjacent region of the implant body. The invention further relates to an implant that can be obtained by such a method.

Abstract: One embodiment of the invention relates to an implant comprising a base body made of a biocorrodible magnesium alloy. The magnesium alloy contains a plurality of statistically distributed particles, comprising one or more of the elements Y, Zr, Mn, Sc, Fe, Ni, Co, W, Pt and noble earths with the atomic numbers 57 to 71, or the particles comprise alloys or compounds containing one or more of the elements mentioned. The mean distance of the particles from each other is smaller than the hundredfold mean particle diameter.

Abstract: A biocorrodible implant includes a base formed from magnesium or a biocorrodible magnesium alloy, whose surface has a corrosion-inhibiting coating. A diffusion layer, which covers the base, differs in composition from the implant material. The diffusion layer contains at least one metallic element of the implant material and at least one corrosion-inhibiting element selected from the group of Al, Zn, Ca, Si, In, Mn, Sc and RE, where RE stands for rare earth metals. The implant optionally includes a metal layer of at least one of the corrosion-inhibiting elements selected from the group of Al, Zn, Ca, Si, In, Mn, Sc and RE covering the diffusion layer, and a passivating layer of metal oxides, metal nitrides or metal fluorides of at least one of the corrosion-inhibiting elements selected from the group of Al, Zn, Ca, Si, In, Mn, Sc and RE covering the diffusion layer or the metal layer.

Abstract: Some embodiments of the present invention relate to coated biological material for the manufacture of heart valve prostheses, characterized in that the surface of the biological material is covered entirely or partially with a coating which contains or is composed of a biocompatible anorganic material, and to a process for manufacturing such a coated biological material.