Patents by Inventor Alexander Shoemaker
Alexander Shoemaker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10934519Abstract: The methods of harvesting cells are provided, wherein the methods comprise introducing a processing material and a source material into a processing loop. The processing loop comprises a processing chamber and a filtering device. The processing material and the source material are circulating through the processing chamber and the filtering device, wherein the processing chamber has a mass; balancing an influx of the processing material into the processing chamber with a permeate flux of the filtering device to maintain the mass of the processing chamber at a constant value; and collecting the cells in a collection chamber. Cell harvesting devices are also provided for processing and harvesting cells using a control law to balance the mass of the processing chamber through the entire process.Type: GrantFiled: July 29, 2011Date of Patent: March 2, 2021Assignee: Global Life Sciences Solutions USA LLCInventors: Jaydeep Roy, Andrew Michael Leach, Weston Blaine Griffin, Stefan Rakuff, Philip Alexander Shoemaker
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Patent number: 10365190Abstract: Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.Type: GrantFiled: January 11, 2016Date of Patent: July 30, 2019Assignee: Whatman International LimitedInventors: Philip Alexander Shoemaker, Weston Blaine Griffin, Erin Jean Finehout, Xuefeng Wang, Kashan Ali Shaikh, Greg Darryl Goddard
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Patent number: 10088399Abstract: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.Type: GrantFiled: May 1, 2015Date of Patent: October 2, 2018Assignee: GENERAL ELECTRIC COMPANYInventors: Weston Blaine Griffin, Jaydeep Roy, Phillip Alexander Shoemaker, William Patrick Waters
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Publication number: 20160282241Abstract: Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.Type: ApplicationFiled: January 11, 2016Publication date: September 29, 2016Inventors: Philip Alexander Shoemaker, Weston Blaine Griffin, Erin Jean Finehout, Xuefeng Wang, Kashan Ali Shaikh, Greg Darryl Goddard
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Patent number: 9347033Abstract: A method of processing an adipose tissue to collect adipose derived regenerative cells is provided, wherein the method comprises providing a vessel comprising a fluid jet mixer, introducing the adipose tissue into the vessel, introducing a buffer solution into the vessel; washing the adipose tissue using the fluid jet mixer; introducing an enzyme solution into the vessel; initiating jet mixing into the vessel comprising the adipose tissue, the enzyme solution, and the buffer solution using the fluid jet mixer to digest the adipose tissue to form a digestion product; phase-separating the digestion product into a digested buoyant fat layer and a non-buoyant aqueous layer; and collecting the non-buoyant aqueous layer comprising the adipose derived regenerative cells. A system of processing an adipose tissue to collect adipose derived regenerative cells is also provided.Type: GrantFiled: July 30, 2015Date of Patent: May 24, 2016Assignee: General Electric CompanyInventors: Zaeem Ashraf Khan, Aaron Joseph Dulgar-Tulloch, Stefan Rakuff, Philip Alexander Shoemaker, Erik Leeming Kvam, Xiaohui Chen, Jaydeep Roy
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Patent number: 9254484Abstract: Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.Type: GrantFiled: March 10, 2014Date of Patent: February 9, 2016Assignee: WHATMAN INTERNATIONAL LIMITEDInventors: Philip Alexander Shoemaker, Weston Blaine Griffin, Erin Jean Finehout, Xuefeng Wang, Kashan Ali Shaikh, Greg Darryl Goddard
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Publication number: 20150337263Abstract: A method of processing an adipose tissue to collect adipose derived regenerative cells is provided, wherein the method comprises providing a vessel comprising a fluid jet mixer, introducing the adipose tissue into the vessel, introducing a buffer solution into the vessel; washing the adipose tissue using the fluid jet mixer; introducing an enzyme solution into the vessel; initiating jet mixing into the vessel comprising the adipose tissue, the enzyme solution, and the buffer solution using the fluid jet mixer to digest the adipose tissue to form a digestion product; phase-separating the digestion product into a digested buoyant fat layer and a non-buoyant aqueous layer; and collecting the non-buoyant aqueous layer comprising the adipose derived regenerative cells. A system of processing an adipose tissue to collect adipose derived regenerative cells is also provided.Type: ApplicationFiled: July 30, 2015Publication date: November 26, 2015Inventors: Zaeem Ashraf Khan, Aaron Joseph Dulgar-Tulloch, Stefan Rakuff, Philip Alexander Shoemaker, Erik Leeming Kvam, Xiaohui Chen, Jaydeep Roy
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Publication number: 20150233803Abstract: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.Type: ApplicationFiled: May 1, 2015Publication date: August 20, 2015Inventors: Weston Blaine Griffin, Jaydeep Roy, Phillip Alexander Shoemaker, William Patrick Waters
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Patent number: 9109198Abstract: A method of processing an adipose tissue to collect adipose derived regenerative cells is provided, wherein the method comprises providing a vessel comprising a fluid jet mixer; introducing the adipose tissue into the vessel; introducing a buffer solution into the vessel; washing the adipose tissue using the fluid jet mixer; introducing an enzyme solution into the vessel; initiating jet mixing into the vessel comprising the adipose tissue, the enzyme solution, and the buffer solution using the fluid jet mixer to digest the adipose tissue to form a digestion product; phase-separating the digestion product into a digested buoyant fat layer and a non-buoyant aqueous layer; and collecting the non-buoyant aqueous layer comprising the adipose derived regenerative cells. A system of processing an adipose tissue to collect adipose derived regenerative cells is also provided.Type: GrantFiled: April 29, 2011Date of Patent: August 18, 2015Assignee: General Electric CompanyInventors: Zaeem Ashraf Khan, Aaron Joseph Dulgar-Tulloch, Stefan Rakuff, Philip Alexander Shoemaker, Erik Leeming Kvam, Xiaohui Chen, Jaydeep Roy
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Patent number: 9034280Abstract: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.Type: GrantFiled: December 16, 2009Date of Patent: May 19, 2015Assignee: GENERAL ELECTRIC CORPORATIONInventors: Weston Blaine Griffin, Jaydeep Roy, Phillip Alexander Shoemaker, William Patrick Waters
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Publication number: 20140248714Abstract: Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.Type: ApplicationFiled: March 10, 2014Publication date: September 4, 2014Applicant: WHATMAN INTERNATIONAL LIMITEDInventors: Philip Alexander Shoemaker, Weston Blaine Griffin, Erin Jean Finehout, Xuefeng Wang, Kashan Ali Shaikh, Greg Darryl Goddard
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Patent number: 8713775Abstract: An apparatus and method are provided for servicing a dynamoelectric machine component. The apparatus includes a tool delivery mechanism adapted for delivering a tool to a desired location in the dynamoelectric machine, and a tool support fixture adapted to be secured onto the body of the dynamoelectric machine, where the tool support fixture can be used for supporting and adjusting the tool delivery mechanism. A sleeve mechanism is attached to the tool support fixture, and the sleeve mechanism is disposed around a portion of the tool delivery mechanism. The apparatus is adapted to service the component of the dynamoelectric machine in-situ.Type: GrantFiled: June 16, 2011Date of Patent: May 6, 2014Assignee: General Electric CompanyInventors: Zhipeng Zhang, Philip Alexander Shoemaker, Robert Jeffrey Pieciuk, Weston Blaine Griffin, Arvind Rangarajan, Diego Quinones, Prabhjot Singh
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Patent number: 8689649Abstract: Automated methods and systems for punching out pieces of a porous substrate for biological samples comprising: loading the porous substrate onto a support comprising a die and an opening; moving a receptacle support in at least a z-direction to position a receptacle relative to the support so that an opening in the receptacle is aligned and substantially flush with the opening in the support; actuating a punching head so that the punching head passes through the die, thereby punching a piece out of the porous substrate; and actuating an ejector pin to eject the punched piece from the porous substrate support and into the receptacle aligned with the opening in the support.Type: GrantFiled: December 4, 2009Date of Patent: April 8, 2014Assignee: General Electric CompanyInventors: Philip Alexander Shoemaker, Weston Blaine Griffin, Erin Jean Finehout
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Patent number: 8685749Abstract: Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.Type: GrantFiled: December 2, 2009Date of Patent: April 1, 2014Assignee: Whatman International LimitedInventors: Philip Alexander Shoemaker, Weston Blaine Griffin, Erin Jean Finehout, Xuefeng Wang, Kashan Ali Shaikh, Greg Darryl Goddard
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Patent number: 8512566Abstract: Disclosed herein is a disposable fluid path for processing complex materials. The disposable fluid path comprises a gravity assisted disposable system for separating a biological sample into two or more distinct submaterials through sedimentation. The fluid path is comprised of a sample delivery conduit and bag-set wherein the bag set comprising a tubing assembly, a separation assembly, and a filter assembly. Methods of using the system are also disclosed.Type: GrantFiled: December 11, 2009Date of Patent: August 20, 2013Assignee: General Electric CompanyInventors: Weston Blaine Griffin, Jaydeep Roy, Eric Douglas Williams, Philip Alexander Shoemaker, James Mitchell White
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Publication number: 20130029411Abstract: The methods of harvesting cells are provided, wherein the methods comprise introducing a processing material and a source material into a processing loop. The processing loop comprises a processing chamber and a filtering device. The processing material and the source material are circulating through the processing chamber and the filtering device, wherein the processing chamber has a mass; balancing an influx of the processing material into the processing chamber with a permeate flux of the filtering device to maintain the mass of the processing chamber at a constant value; and collecting the cells in a collection chamber. Cell harvesting devices are also provided for processing and harvesting cells using a control law to balance the mass of the processing chamber through the entire process.Type: ApplicationFiled: July 29, 2011Publication date: January 31, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Jaydeep Roy, Andrew Michael Leach, Weston Blaine Griffin, Stefan Rakuff, Philip Alexander Shoemaker
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Publication number: 20130017360Abstract: An apparatus separates a band of resin-impregnated fiber material into strips and disposes the strips between parallel pin rows of a pinmat to form a layer of strips. The apparatus includes a pinmat-following roller comprising a first roller mounted on a first central axle on which the first roller can rotate and slide transversely, a first circular rib surrounding the first roller and capable of fitting between adjacent pin rows of a pinmat, and a circular groove in the first roller for coupling with the band-separating roller. The apparatus further includes a band-separating roller comprising a second roller mounted on a second central axle on which the second roller can rotate and slide transversely, multiple radially projecting disks from the second roller for separating the band of resin-impregnated fiber, and a second circular rib surrounding the second roller capable of coupling with the circular groove of the pinmat-following roller.Type: ApplicationFiled: January 12, 2012Publication date: January 17, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Mark Ernest Vermilyea, BOWDEN KIRKPATRICK, PHILIP ALEXANDER SHOEMAKER, TERRENCE PAUL VERNES
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Patent number: 8354404Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.Type: GrantFiled: April 25, 2011Date of Patent: January 15, 2013Assignee: Abbott LaboratoriesInventors: Milan Bruncko, Hong Ding, Steven Elmore, Aaron Kunzer, Christopher L. Lynch, William McClellan, Cheol-Min Park, Andrew Petros, Xiaohong Song, Xilu Wang, Noah Tu, Michael Wendt, Alexander Shoemaker, Michael Mitten
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Publication number: 20120317771Abstract: An apparatus and method are provided for servicing a dynamoelectric machine component. The apparatus includes a tool delivery mechanism adapted for delivering a tool to a desired location in the dynamoelectric machine, and a tool support fixture adapted to be secured onto the body of the dynamoelectric machine, where the tool support fixture can be used for supporting and adjusting the tool delivery mechanism. A sleeve mechanism is attached to the tool support fixture, and the sleeve mechanism is disposed around a portion of the tool delivery mechanism. The apparatus is adapted to service the component of the dynamoelectric machine in-situ.Type: ApplicationFiled: June 16, 2011Publication date: December 20, 2012Inventors: Zhipeng Zhang, Philip Alexander Shoemaker, Robert Jeffrey Pieciuk, Weston Blaine Griffin, Arvind Rangarajan, Diego Quinones, Prabhjot Singh
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Publication number: 20120276628Abstract: A method of processing an adipose tissue to collect adipose derived regenerative cells is provided, wherein the method comprises providing a vessel comprising a fluid jet mixer; introducing the adipose tissue into the vessel; introducing a buffer solution into the vessel; washing the adipose tissue using the fluid jet mixer; introducing an enzyme solution into the vessel; initiating jet mixing into the vessel comprising the adipose tissue, the enzyme solution, and the buffer solution using the fluid jet mixer to digest the adipose tissue to form a digestion product; phase-separating the digestion product into a digested buoyant fat layer and a non-buoyant aqueous layer; and collecting the non-buoyant aqueous layer comprising the adipose derived regenerative cells. A system of processing an adipose tissue to collect adipose derived regenerative cells is also provided.Type: ApplicationFiled: April 29, 2011Publication date: November 1, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Zaeem Ashraf Khan, Aaron Joseph Dulgar-Tulloch, Stefan Rakuff, Philip Alexander Shoemaker, Erik Leeming Kvam, Xiaohui Chen, Jaydeep Roy