Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for receiving, from one of two or more sensors of a device that independently determine whether an aircraft takeoff has likely occurred, an indication that the aircraft takeoff has likely occurred; activating, based on receiving the indication that the aircraft takeoff has likely occurred, an airplane mode of the device; receiving, while the device is in the airplane mode and from one of two or more other sensors of the device that independently determine that an aircraft flight is likely not occurring, an indication that the aircraft flight is likely not occurring; and deactivating, based on receiving the indication that the aircraft flight is likely not occurring, the airplane mode of the device. The indication that the aircraft takeoff has likely occurred may include acceleration data indicating an acceleration of the device in three dimensions.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for receiving, from one of two or more sensors of a device that independently determine whether an aircraft takeoff has likely occurred, an indication that the aircraft takeoff has likely occurred; activating, based on receiving the indication that the aircraft takeoff has likely occurred, an airplane mode of the device; receiving, while the device is in the airplane mode and from one of two or more other sensors of the device that independently determine that an aircraft flight is likely not occurring, an indication that the aircraft flight is likely not occurring; and deactivating, based on receiving the indication that the aircraft flight is likely not occurring, the airplane mode of the device. The indication that the aircraft takeoff has likely occurred may include acceleration data indicating an acceleration of the device in three dimensions.

Abstract: A method and network device for overlay tunnel termination and mirroring spanning datacenters. Specifically, the method and network device disclosed herein entail the traversal of mirrored network traffic from datacenters lacking traffic analysis tools to other datacenters including the sought after traffic analysis tools. Further, the aforementioned traversal of mirrored network traffic may utilize virtual network layer overlay domain tunnels.

Abstract: A method and network device for overlay tunnel termination and mirroring spanning datacenters. Specifically, the method and network device disclosed herein entail the traversal of mirrored network traffic from datacenters lacking traffic analysis tools to other datacenters including the sought after traffic analysis tools. Further, the aforementioned traversal of mirrored network traffic may utilize virtual network layer overlay domain tunnels.