Patents by Inventor Alexander W. Rhind

Alexander W. Rhind has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microplate thermal shift assay apparatus for ligand development and multi-variable protein chemistry optimization
    Patent number: 6849458
    Abstract: The present invention provides an assay apparatus for that includes a temperature adjusting means for simultaneously heating a plurality of samples, and a receiving means for receiving spectral emission from the samples while the samples are being heated. In further aspects of the invention, the receiving means can be configured to receive fluorescent emission, ultraviolet light, and visible light. The receiving means can be configured to receive spectral emission from the samples in a variety of ways, e.g., one sample at a time, simultaneously from more than one sample, or simultaneously from all of the samples. The temperature adjusting means can be configured with a temperature controller for changing temperature in accordance with a predetermined profile.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: February 1, 2005
    Inventors: Michael W. Pantoliano, Roger F. Bone, Alexander W. Rhind, Francis R. Salemme
  • Microplate thermal shift assay apparatus for ligand development and multi-variable protein chemistry optimization
    Publication number: 20040185504
    Abstract: The present invention provides an assay apparatus for that includes a temperature adjusting means for simultaneously heating a plurality of samples, and a receiving means for receiving spectral emission from the samples while the samples are being heated. In further aspects of the invention, the receiving means can be configured to receive fluorescent emission, ultraviolet light, and visible light. The receiving means can be configured to receive spectral emission from the samples in a variety of ways, e.g., one sample at a time, simultaneously from more than one sample, or simultaneously from all of the samples. The temperature adjusting means can be configured with a temperature controller for changing temperature in accordance with a pre-determined profile.
    Type: Application
    Filed: April 7, 2004
    Publication date: September 23, 2004
    Inventors: Michael W. Pantoliano, Roger F. Bone, Alexander W. Rhind, Francis R. Salemme
  • Microplate thermal shift assay apparatus for ligand development and multi-variable protein chemistry optimization
    Publication number: 20030203497
    Abstract: The present invention provides an assay apparatus for that includes a temperature adjusting means for simultaneously heating a plurality of samples, and a receiving means for receiving spectral emission from the samples while the samples are being heated. In further aspects of the invention, the receiving means can be configured to receive fluorescent emission, ultraviolet light, and visible light. The receiving means can be configured to receive spectral emission from the samples in a variety of ways, e.g., one sample at a time, simultaneously from more than one sample, or simultaneously from all of the samples. The temperature adjusting means can be configured with a temperature controller for changing temperature in accordance with a pre-determined profile.
    Type: Application
    Filed: April 22, 2003
    Publication date: October 30, 2003
    Inventors: Michael W. Pantoliano, Roger F. Bone, Alexander W. Rhind, Francis R. Salemme
  • Microplate thermal shift assay apparatus for ligand development and multi-variable protein chemistry optimization
    Publication number: 20020114734
    Abstract: The present invention provides an assay apparatus for that includes a temperature adjusting means for simultaneously heating a plurality of samples, and a receiving means for receiving spectral emission from the samples while the samples are being heated. In further aspects of the invention, the receiving means can be configured to receive fluorescent emission, ultraviolet light, and visible light. The receiving means can be configured to receive spectral emission from the samples in a variety of ways, e.g., one sample at a time, simultaneously from more than one sample, or simultaneously from all of the samples. The temperature adjusting means can be configured with a temperature controller for changing temperature in accordance with a predetermined profile.
    Type: Application
    Filed: March 9, 2001
    Publication date: August 22, 2002
    Inventors: Michael W. Pantoliano, Roger F. Bone, Alexander W. Rhind, Francis R. Salemme
  • Method for identifying lead compounds
    Patent number: 6303322
    Abstract: The present invention is a method for ranking the affinity of each of a multiplicity of different molecules for a target molecule which is capable of denaturing due to a thermal change.
    Type: Grant
    Filed: January 5, 2000
    Date of Patent: October 16, 2001
    Assignee: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Michael W. Pantoliano, Alexander W. Rhind, Francis R. Salemme
  • Microplate thermal shift assay for ligand development and multi-variable protein chemistry optimization
    Patent number: 6291191
    Abstract: The present invention is a method for ranking the affinity of each of a multiplicity of different molecules for a target molecule which is capable of denaturing due to a thermal change.
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: September 18, 2001
    Assignee: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Michael W. Pantoliano, Eugenio C. Petrella, Alexander W. Rhind, Francis R. Salemme, Barry A. Springer
  • Method for sensing and processing fluorescence data from multiple samples
    Patent number: 6268218
    Abstract: The present invention provides an assay apparatus for that includes a temperature adjusting device for simultaneously heating a plurality of samples, and a receiving device for receiving spectral emission from the samples while the samples are being heated. In further aspects of the invention, the receiving device can be configured to receive fluorescent emission, ultraviolet light, and visible light. The receiving device can be configured to receive spectral emission from the samples in a variety of ways, e.g., one sample at a time, simultaneously from more than one sample, or simultaneously from all of the samples. The temperature adjusting device can be configured with a temperature controller for changing temperature in accordance with a pre-determined profile.
    Type: Grant
    Filed: December 14, 1999
    Date of Patent: July 31, 2001
    Assignee: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Michael W. Pantoliano, Roger F. Bone, Alexander W. Rhind, Francis R. Salemme
  • Microplate thermal shift assay apparatus for ligand development and multi-variable protein chemistry optimization
    Patent number: 6214293
    Abstract: The present invention provides an assay apparatus for that includes a temperature adjusting means for simultaneously heating a plurality of samples, and a receiving means for receiving spectral emission from the samples while the samples are being heated. In further aspects of the invention, the receiving means can be configured to receive fluorescent emission, ultraviolet light, and visible light. The receiving means can be configured to receive spectral emission from the samples in a variety of ways, e.g., one sample at a time, simultaneously from more than one sample, or simultaneously from all of the samples. The temperature adjusting means can be configured with a temperature controller for changing temperature in accordance with a pre-determined profile.
    Type: Grant
    Filed: December 14, 1999
    Date of Patent: April 10, 2001
    Assignee: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Michael W. Pantoliano, Roger F. Bone, Alexander W. Rhind, Francis R. Salemme
  • Microplate thermal shift assay apparatus for ligand development and multi-variable protein chemistry optimization
    Patent number: 6036920
    Abstract: The present invention provides an assay apparatus for that includes a temperature adjusting device for simultaneously heating a plurality of samples, and a receiving device for receiving spectral emission from the samples while the samples are being heated. In further aspects of the invention, the receiving device can be configured to receive fluorescent emission, ultraviolet light, and visible light. The receiving device can be configured to receive spectral emission from the samples in a variety of ways, e.g., one sample at a time, simultaneously from more than one sample, or simultaneously from all of the samples. The temperature adjusting device can be configured with a temperature controller for changing temperature in accordance with a pre-determined profile.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: March 14, 2000
    Assignee: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Michael W. Pantoliano, Roger F. Bone, Alexander W. Rhind, Francis R. Salemme
  • Microplate thermal shift assay for ligand development and multi-variable protein chemistry optimization
    Patent number: 6020141
    Abstract: The present invention is a method for ranking the affinity of each of a multiplicity of different molecules for a target molecule which is capable of denaturing due to a thermal change. The method comprises contacting the target molecule with one molecule of the multiplicity of different molecules in each of a multiplicity of containers, simultaneously heating the multiplicity of containers, measuring in each of the containers a physical change associated with the thermal denaturation of the target molecule resulting from the heating in each of the containers, generating a thermal denaturation curve for the target molecule as a function of temperature for each of the containers and determining a midpoint temperature (T.sub.m) therefrom, comparing the T.sub.m of each of the thermal denaturation curves with the T.sub.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: February 1, 2000
    Assignee: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Michael W. Pantoliano, Alexander W. Rhind, Francis R. Salemme