Patents by Inventor Alexandra Lithadioti

Alexandra Lithadioti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • One-pot organo-pseudocatalytic C—H activation approach for the preparation of vortioxetine and vortioxetine intermediate
    Patent number: 11198671
    Abstract: The present invention relates to a novel process for the preparation of Vortioxetine and a key intermediate thereof by employing a novel one-pot organo-pseudocatalytic C—H activation approach via hypervalent iodine chemistry.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: December 14, 2021
    Assignee: VIO AG PHARMACEUTICALS S.A.
    Inventors: Theocharis V. Koftis, Efstratios Neokosmidis, Thanos Andreou, Petros Gkizis, Alexandra Lithadioti
  • A ONE-POT ORGANO-PSEUDOCATALYTIC C-H ACTIVATION APPROACH FOR THE PREPARATION OF VORTIOXETINE AND VORTIOXETINE INTERMEDIATE
    Publication number: 20210163407
    Abstract: The present invention relates to a novel process for the preparation of Vortioxetine and a key intermediate thereof by employing a novel one-pot organo-pseudocatalytic C—H activation approach via hypervalent iodine chemistry.
    Type: Application
    Filed: June 19, 2019
    Publication date: June 3, 2021
    Applicant: VIO AG PHARMACEUTICALS S.A.
    Inventors: THEOCHARIS V. KOFTIS, EFSTRATIOS NEOKOSMIDIS, THANOS ANDREOU, PETROS GKIZIS, ALEXANDRA LITHADIOTI
  • Process for the preparation of O-desmethyl-venlafaxine and salts thereof
    Patent number: 8754261
    Abstract: The present invention relates to a novel process for the preparation of O-desmethyl venlafaxine (ODV) and the pharmaceutically acceptable salts thereof, wherein it comprises (i) provision of spiro-venlafaxine compound as intermediate; (ii) conversion of spiro-venlafaxine intermediate into ODV free base in a one-pot process; and (iii) optionally conversion ODV free base into pharmaceutically acceptable salts. The present invention further relates to novel processes for the preparation of crystalline salts of ODV-succinate and ODV-oxalate.
    Type: Grant
    Filed: December 16, 2009
    Date of Patent: June 17, 2014
    Assignee: Pharmathen S.A.
    Inventors: Theoharis V. Koftis, Ioanna Georgopoulou, Alexandros Strongilos, Fotini Liepouri, Theodoros Panagiotidis, Alexandra Lithadioti
  • PROCESS FOR THE PREPARATION OF O-DESMETHYL-VENLAFAXINE AND SALTS THEREOF
    Publication number: 20120253074
    Abstract: The present invention relates to a novel process for the preparation of O-desmethyl venlafaxine (ODV) and the pharmaceutically acceptable salts thereof, wherein it comprises (i) provision of spiro-venlafaxine compound as intermediate; (ii) conversion of spiro-venlafaxine intermediate into ODV free base in a one-pot process; and (iii) optionally conversion ODV free base into pharmaceutically acceptable salts. The present invention further relates to novel processes for the preparation of crystalline salts of OD V-succinate and ODV-oxalate.
    Type: Application
    Filed: December 16, 2009
    Publication date: October 4, 2012
    Applicant: PHARMATHEN S.A.
    Inventors: Theoharis V. Koftis, Ioanna Georgopoulou, Alexandros Strongilos, Fotini Liepouri, Theodoros Panagiotidis, Alexandra Lithadioti
  • PROCESS FOR THE PREPARATION OF FLUVASTATIN AND SALTS THEREOF
    Publication number: 20120035374
    Abstract: The present invention relates to an improved process for the preparation of fluvastatin or pharmaceutical acceptable salts or derivatives thereof, in particular to a one-pot process for large scale production of Fluvastatin and salts thereof in high yield and high purity and pharmaceutical preparations containing said compounds.
    Type: Application
    Filed: April 15, 2009
    Publication date: February 9, 2012
    Applicant: PHARMATHEN S.A.
    Inventors: Theoharis V. Koftis, Thoedoros Panagiotidis, Rohit Ravikant Soni, Alexandra Lithadioti