Abstract: A pulse wave imaging system, more generally a system for measuring blood perfusion, comprising a configuration of a computing device and a camera is described. The system, and the methods used therein, produce a more robust measurement of several tissue health indicators. Variations and improvements on the basic system are also described.

Abstract: An imaging sensing system containing: i) a fibre optic plate (FOP) having a proximal end, a distal end and a body situated between the proximal and distal ends; ii) at least one illumination component, and ii) an image sensor proximate the FOP.

Abstract: A device and method for passing information to a person using cutaneous facial stimulation to generate phosphenes is described. This invention has many uses, but in particular it can be used to transmit visuo-spatial information to a person who is blind or has impaired vision. Electrodes are attached to the face in known positions, and stimulated in an order to create a desired phosphene pattern in the user's field of vision. Masks are described to assist with holding the electrodes in place and to carry associated circuitry and sensors. Voltage waveform conditions are also identified to minimize pain associated with the use of the device.

Abstract: Endoscope apparatuses for generating at least one image of a portion of an object are described herein. The endoscope apparatus includes an ultrafine needle adapted for insertion into the object; a fiber probe that is slidably disposed in the ultrafine needle, the fiber probe including a plurality of optical fibers or cores that act as illumination optical fibers and collection optical fibers; an optical assembly that is coupled to the fiber probe, the optical assembly including: at least one transmission optical pathway to provide at least one excitation light signal to the portion of the object to be imaged during use; and at least one return optical pathway that is adapted to transmit reflected light signals from the portion of the object when it is illuminated during use with at least one sensor for generating at least one image via at least one set of optical elements.

Abstract: An imaging sensing system containing: i) a fibre optic plate (FOP) having a proximal end, a distal end and a body situated between the proximal and distal ends; ii) at least one illumination component; and ii) an image sensor proximate the FOP.

Abstract: A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume THB and oxygenation SO2. A pull-back approach of spectral data acquisition is disclosed which takes into account tissue motility in esophagus and measurement geometry peculiarities. The pull-back approach provides a significant improvement of measurement reproducibility and reduction of data deviation by 75-100%, resulting in a better discrimination between different histological groups.

Abstract: A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume THB and oxygenation SO2. A pull-back approach of spectral data acquisition is disclosed which takes into account tissue motility in esophagus and measurement geometry peculiarities. The pull-back approach provides a significant improvement of measurement reproducibility and reduction of data deviation by 75-100%, resulting in a better discrimination between different histological groups.

Abstract: A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume THB and oxygenation SO2. A pull-back approach of spectral data acquisition is disclosed which takes into account tissue motility in esophagus and measurement geometry peculiarities. The pull-back approach provides a significant improvement of measurement reproducibility and reduction of data deviation by 75-100%, resulting in a better discrimination between different histological groups.