Abstract: The present invention relates to a method for remote control release of encapsulated substances by external forces such as ultrasound or light.

Abstract: The invention concerns a method for producing nanocapsules and microcapsules comprising a polyelectrolyte shell by surface precipitation from the solution, by applying a shell to template particles comprising the steps (a) providing a dispersion of template particles of suitable size in a salt-containing liquid phase which contains the components required to form the shell in a dissolved form and (b) precipitating the components from the liquid phase onto the template particles under conditions which enable the formation of a shell around the template particles that has a thickness of from 1 to 100 nm.

Abstract: The invention relates to a method for applying a shell to liquid template particles, comprising the following steps: (a) preparation of an emulsion of liquid template particles in a continuous liquid or gel phase, whereby at least one amphiphilic polyelectrolyte or polyelectrolyte complex, or a copolymer of charged hydrophilic monomers and oil soluble monomers is dissolved in the fluid template particles and/or the continuous phase and a film is formed at the phase boundary between the liquid template particle and the continuous phase and (b) application of a shell to the film formed at the phase boundary.

Abstract: Method of layer-by-layer (LbL) assembly of oppositely charged polyelectrolytes was applied to coat fluorescein particles. These particles with a size of 4-9 &mgr;m were prepared by precipitation of fluorescein at pH 2. Polysterensulfonate (PSS) and polyallylamine (PAH) were used to compose the polyelectrolyte shell on the fluorescein core. The release of fluorescein molecules through the polyelectrolyte shell core dissolution was monitored at pH 8 by increasing fluorescence intensity. The number of polyelectrolyte layers sufficient to sustain fluorescence release was found to be 8-10. Sequentially adsorbed layers prolong core dissolution time for minutes. The permeability of polyelectrolyte multilayers of the thickness of 20 nm is about 10−8 m/s. Mechanism of fluorescence diffusion and osmotically supported release is under discussion. The features of release profile and possible applications or LbL method for shell formation in order to control release properties for entrapped materials are outlined.

Abstract: The invention concerns a method for producing nanocapsules and microcapsules comprising a polyelectrolyte shell by surface precipitation from the solution, by applying a shell to template particles comprising the steps (a) providing a dispersion of template particles of suitable size in a salt-containing liquid phase which contains the components required to form the shell in a dissolved form and (b) precipitating the components from the liquid phase onto the template particles under conditions which enable the formation of a shell around the template particles that has a thickness of from 1 to 100 nm.