Patents by Inventor Alexey V. Kharitonov

Alexey V. Kharitonov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for determining the risk of cardiovascular events using IGFBP fragments
    Patent number: 10191066
    Abstract: The present invention describes the method for determining the risk of future major adverse cardiovascular events, which comprises detection proteolytic fragments of IGFBP-4 or IGFBP-5 (insulin-like growth factor binding protein 4 or insulin-like growth factor binding protein 5) in patients' blood. The present invention provides antibodies and immunoas-says, suitable for specific measurement of proteolytic fragments of IGFBPs. In current invention the IGFBP fragments are suggested to be utilized as blood biomarkers for the risk prediction of major adverse cardiovascular events (MACE).
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: January 29, 2019
    Assignee: HYTEST LTD.
    Inventors: Alexey G. Katrukha, Alexander B. Postnikov, Tatiana I. Smolyanova, Alexey V. Kharitonov, Natalia N. Tamm
  • Method for detection of IGFBP-4 fragments
    Patent number: 9964549
    Abstract: Disclosed is a method for detecting IGFBP-4 (Insulin-like Growth Factor Binding Protein-4) fragments. The method uses antibodies or antigen binding fragments that specifically recognize epitopes on IGFBP-4 fragments. The IGFBP-4 fragments include the N-terminal and C-terminal fragments resulting from PAPP-A dependent cleavage of IGFBP-4. Assay and diagnostic methods using detection of IGFBP-4 fragments are also disclosed.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: May 8, 2018
    Assignee: HYTEST LTD.
    Inventors: Alexey G. Katrukha, Alexander B. Postnikov, Tatiana I. Solovyeva, Alexey V. Kharitonov
  • DIAGNOSTIC KIT FOR IGFBP-4 PROTEOLYTIC FRAGMENTS IN A PATIENT SAMPLE
    Publication number: 20150219671
    Abstract: The present invention relates to a method for diagnosing a cardiovascular or cancer disease by detecting IGFBP-4 (Insulin-like Growth Factor Binding Protein-4) fragments in a patient sample. Antibodies specifically recognizing novel epitopes originated by enzyme-dependent cleavage of IGFBP-4 are also disclosed.
    Type: Application
    Filed: March 20, 2015
    Publication date: August 6, 2015
    Applicant: HYTEST LTD.
    Inventors: Alexey G. KATRUKHA, Alexander B. POSTNIKOV, Tatiana I. SOLOVYEVA, Alexey V. KHARITONOV
  • Diagnostic kit for IGFBP-4 proteolytic fragments in a patient sample
    Patent number: 9012610
    Abstract: The present invention relates to a method for diagnosing a cardiovascular or cancer disease by detecting IGFBP-4 (Insulin-like Growth Factor Binding Protein-4) fragments in a patient sample. Antibodies specifically recognizing novel epitopes originated by enzyme-dependent cleavage of IGFBP-4 are also disclosed.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: April 21, 2015
    Assignee: Hytest Ltd.
    Inventors: Alexey G. Katrukha, Alexander B. Postnikov, Tatiana I. Solovyeva, Alexey V. Kharitonov
  • METHOD FOR DETERMINING THE RISK OF CARDIOVASCULAR EVENTS USING IGFBP FRAGMENTS
    Publication number: 20140017714
    Abstract: The present invention describes the method for determining the risk of future major adverse cardiovascular events, which comprises detection proteolytic fragments of IGFBP-4 or IGFBP-5 (insulin-like growth factor binding protein 4 or insulin-like growth factor binding protein 5) in patients' blood. The present invention provides antibodies and immunoas-says, suitable for specific measurement of proteolytic fragments of IGFBPs. In current invention the IGFBP fragments are suggested to be utilized as blood biomarkers for the risk prediction of major adverse cardiovascular events (MACE).
    Type: Application
    Filed: April 13, 2012
    Publication date: January 16, 2014
    Applicant: HYTEST LTD.
    Inventors: Alexey G. Katrukha, Alexander B. Postnikov, Tatiana I. Smolyanova, Alexey V. Kharitonov, Natalia N. Tamm
  • DETECTION OF IGFBP-4 FRAGMENTS AS A DIAGNOSTIC METHOD
    Publication number: 20120178113
    Abstract: The present invention relates to a method for diagnosing a cardiovascular or cancer disease by detecting IGFBP-4 (Insulin-like Growth Factor Binding Protein-4) fragments in a patient sample. Antibodies specifically recognizing novel epitopes originated by enzyme-dependent cleavage of IGFBP-4 are also disclosed.
    Type: Application
    Filed: June 29, 2010
    Publication date: July 12, 2012
    Applicant: HYTEST LTD.
    Inventors: Alexey G. Katrukha, Alexander B. Postnikov, Tatiana I. Solovyeva, Alexey V. Kharitonov