Patents by Inventor Alf S. Nygren

Alf S. Nygren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-(3,5-disubstituted phenylazo)-2-hydroxybenzene-acetic acids and salts and lactones thereof having a potentially inhibitory effect on 15-hydroxy-prostaglandin dehydrogenase
    Patent number: 4725676
    Abstract: The present invention is concerned with azo compounds having the structure ##STR1## in which: Y is hydrogen, andX and Z are carboxy or lower alkoxycarbonyl,or the lactones or salts of said azo compound, such compounds being useful in pharmaceutical compositions and being specifically useful to inhibit 15-prostaglandin dehydrogenase (PGDH).
    Type: Grant
    Filed: July 3, 1986
    Date of Patent: February 16, 1988
    Assignee: Pharmacia AB
    Inventors: Karl H. Agback, Alf S. Nygren
  • Novel arylacetic acid derivatives
    Patent number: 4695648
    Abstract: A compound having a potentially inhibitory effect on 15-hydroxy-prostaglandin dehydrognase (PGDH) and having the formula ##STR1## in which R.sub.1 and R.sub.2 are hydrogen or lower alkyl;R.sub.3 is hydrogen, lower alkyl or substituted or unsubstituted phenyl;R.sub.4, R.sub.5, and R.sub.6 are hydrogen, halogen, lower alkyl, lower alkoxy, cyano, carboxy or nitro; at least one of the groups R.sub.4 to R.sub.6 being hydrogen;R.sub.7 to R.sub.11 are hydrogen, halogen, cyano, lower alkyl, trifluoromethyl, lower alkoxy, hydroxy, lower acyl, lower alkoxycarbonyl, N,N,-diloweralkyl-aminocarbonyl or N,N-loweralkylene-aminocarbonyl; and R.sub.8 and R.sub.10 may in addition be carboxy; at least two of R.sub.7 to R.sub.11 always being hydrogen; and--A-- is --CO--, --CH.sub.2 --CO--, --CH.dbd.CH--, --CH.dbd.CH--CO-- or corresponding groups in which a hydrogen atom is replaced by a lower alkyl group.The invention comprises also lactones of those compounds in which R.sub.
    Type: Grant
    Filed: August 29, 1985
    Date of Patent: September 22, 1987
    Assignee: Pharmacia AB
    Inventors: Karl H. Agback, Tamara Agback, Alf S. Nygren
  • Method and intermediates for preparing high purity 3,3'-azo-bis-(6-hydroxy benzoic acid)
    Patent number: 4528367
    Abstract: A method of preparing 3,3'-azo-bis-(6-hydroxy benzoic acid) of formula I ##STR1## and salts thereof in at least 98% purity for treating inflammatory intestinal diseases. According to the invention a compound II ##STR2## is diazotized, and the diazonium salt obtained is coupled with a compound III ##STR3## The formed intermediate IV, which is also comprised by the invention, ##STR4## is hydrolized in alkaline medium to form the compound I. R.sub.1, R.sub.2 and R.sub.3 signify lower alkyl, R.sub.2 also possibly substituted phenyl.
    Type: Grant
    Filed: January 31, 1983
    Date of Patent: July 9, 1985
    Assignee: Pharmacia AB
    Inventors: Karl H. Agback, Alf S. Nygren