Patents by Inventor Alfonso Bellacosa

Alfonso Bellacosa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of thymine DNA glycosylase in the treatment of cancer
    Patent number: 11883413
    Abstract: The invention provides compositions, kits, and methods for inducing growth arrest, differentiation, or senescence of cancer cells that express thymine DNA glycosylase, and treating the cancer accordingly. The methods comprise inhibiting expression or biologic activity of thymine DNA glycosylase in cancer cells. Inhibition of thymine DNA glycosylase in cancer cells may induce the cells to revert to a healthy, non-cancerous phenotype and/or may induce the cells to senesce. Cancer cells include melanoma, lung, prostate, pancreatic, ovarian, brain, colon, recto-sigmoid colon, and breast cancer cells.
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: January 30, 2024
    Inventors: Alfonso Bellacosa, Rossella Tricarico, Tim Yen, Vikram Bhattacharjee, Pietro Mancuso, Lionel Larue, Irwin Davidson
  • Inhibition of Thymine DNA Glycosylase in the Treatment of Cancer
    Publication number: 20220054500
    Abstract: The invention provides compositions, kits, and methods for inducing growth arrest, differentiation, or senescence of cancer cells that express thymine DNA glycosylase, and treating the cancer accordingly. The methods comprise inhibiting expression or biologic activity of thymine DNA glycosylase in cancer cells. Inhibition of thymine DNA glycosylase in cancer cells may induce the cells to revert to a healthy, non-cancerous phenotype and/or may induce the cells to senesce. Cancer cells include melanoma, lung, prostate, pancreatic, ovarian, brain, colon, recto-sigmoid colon, and breast cancer cells.
    Type: Application
    Filed: June 25, 2021
    Publication date: February 24, 2022
    Inventors: Alfonso Bellacosa, Rossella Tricarico, Tim Yen, Vikram Bhattacharjee, Pietro Mancuso, Lionel Larue, Irwin Davidson
  • Inhibition of thymine DNA glycosylase in the treatment of cancer
    Patent number: 11077121
    Abstract: The invention provides compositions, kits, and methods for inducing growth arrest, differentiation, or senescence of cancer cells that express thymine DNA glycosylase, and treating the cancer accordingly. The methods comprise inhibiting expression or biologic activity of thymine DNA glycosylase in cancer cells. Inhibition of thymine DNA glycosylase in cancer cells may induce the cells to revert to a healthy, non-cancerous phenotype and/or may induce the cells to senesce. Cancer cells include melanoma, lung, prostate, pancreatic, ovarian, brain, colon, recto-sigmoid colon, and breast cancer cells.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: August 3, 2021
    Assignees: Institute For Cancer Research, Institut Curie, Institut de Genetique et de Biologie Moleculaire et Cellulaire
    Inventors: Alfonso Bellacosa, Rossella Tricarico, Tim Yen, Vikram Bhattacharjee, Pietro Mancuso, Lionel Larue, Irwin Davidson
  • Combination of DNA repair inhibition with bendamustine or gemcitabine in the treatment of cancer
    Patent number: 10220051
    Abstract: The invention provides methods for enhancing the cytotoxicity of DNA damage in cancer cells that express thymine DNA glycosylase, and treating tumors accordingly. The methods comprise inhibiting the expression or biologic activity of thymine DNA glycosylase, and inducing DNA damage in the cancer cells. DNA damage may be induced by administration of bendamustine or gemcitabine to the cancer cells.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: March 5, 2019
    Inventors: Alfonso Bellacosa, Timothy Yen, Neil Beeharry, Mitchell Smith, Rossella Tricarico, Vikram Bhattacharjee, Pietro Mancuso
  • Inhibition of Thymine DNA Glycosylase in the Treatment of Cancer
    Publication number: 20160199381
    Abstract: The invention provides compositions, kits, and methods for inducing growth arrest, differentiation, or senescence of cancer cells that express thymine DNA glycosylase, and treating the cancer accordingly. The methods comprise inhibiting expression or biologic activity of thymine DNA glycosylase in cancer cells. Inhibition of thymine DNA glycosylase in cancer cells may induce the cells to revert to a healthy, non-cancerous phenotype and/or may induce the cells to senesce. Cancer cells include melanoma, lung, prostate, pancreatic, ovarian, brain, colon, recto-sigmoid colon, and breast cancer cells.
    Type: Application
    Filed: March 30, 2016
    Publication date: July 14, 2016
    Inventors: Alfonso Bellacosa, Rossella Tricarico, Tim Yen, Vikram Bhattacharjee, Pietro Mancuso, Lionel Larue, Irwin Davidson
  • COMBINATION OF DNA REPAIR INHIBITION WITH BENDAMUSTINE OR GEMCITABINE IN THE TREATMENT OF CANCER
    Publication number: 20150164934
    Abstract: The invention provides methods for enhancing the cytotoxicity of DNA damage in cancer cells that express thymine DNA glycosylase, and treating tumors accordingly. The methods comprise inhibiting the expression or biologic activity of thymine DNA glycosylase, and inducing DNA damage in the cancer cells. DNA damage may be induced by administration of bendamustine or gemcitabine to the cancer cells.
    Type: Application
    Filed: November 13, 2014
    Publication date: June 18, 2015
    Inventors: ALFONSO BELLACOSA, TIMOTHY YEN, NEIL BEEHARRY, MITCHELL SMITH, ROSSELLA TRICARICO, VIKRAM BHATTACHARJEE, PIETRO MANCUSO
  • Combination of DNA repair inhibition with bendamustine or gemcitabine in the treatment of cancer
    Patent number: 8927516
    Abstract: The invention provides methods for enhancing the cytotoxicity of DNA damage in cancer cells that express thymine DNA glycosylase, and treating tumors accordingly. The methods comprise inhibiting the expression or biologic activity of thymine DNA glycosylase, and inducing DNA damage in the cancer cells. DNA damage may be induced by administration of bendamustine or gemcitabine to the cancer cells.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 6, 2015
    Assignee: Institute for Cancer Research
    Inventors: Alfonso Bellacosa, Timothy Yen, Neil Beeharry, Mitchell Smith
  • Gene encoding a DNA repair enzyme and methods of use thereof
    Patent number: 7829671
    Abstract: An isolated nucleic acid molecule encoding a human DNA repair enzyme, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids, proteins and antibodies thereto may be used to advantage in genetic or cancer screening assays. MED1, which recognizes and cleaves DNA, may also be used for the diagnostic detection of mutations and genetic variants.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: November 9, 2010
    Assignee: Fox Chase Cancer Center
    Inventor: Alfonso Bellacosa
  • NOVEL GENE ENCODING A DNA REPAIR ENZYME AND METHODS OF USE THEREOF
    Publication number: 20090274681
    Abstract: An isolated nucleic acid molecule encoding a human DNA repair enzyme, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids, proteins and antibodies thereto may be used to advantage in genetic or cancer screening assays. MED1, which recognizes and cleaves DNA, may also be used for the diagnostic detection of mutations and genetic variants.
    Type: Application
    Filed: January 16, 2009
    Publication date: November 5, 2009
    Inventor: Alfonso Bellacosa
  • Methods and Compositions for Assessing Alterations in Gene Expression Patterns in Clinically Normal Tissues Obtained from Heterozygous Carriers of Mutant Genes Associated with Cancer and Methods of Use Thereof
    Publication number: 20090215642
    Abstract: Compositions, kits, and methods are provided for assessing alterations in gene expression in heterozygous carriers of mutant genes associated with cancer.
    Type: Application
    Filed: December 11, 2006
    Publication date: August 27, 2009
    Inventors: Alfred G. Knudson, Alfonso Bellacosa, Margie L. Clapper, James A. Crowell, Levy Kopelovich
  • Gene encoding a DNA repair enzyme and methods of use thereof
    Patent number: 7491807
    Abstract: An isolated nucleic acid molecule encoding a human DNA repair enzyme, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids, proteins and antibodies thereto may be used to advantage in genetic or cancer screening assays. MED1, which recognizes and cleaves DNA, may also be used for the diagnostic detection of mutations and genetic variants.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: February 17, 2009
    Assignee: Fox Chase Cancer Center
    Inventor: Alfonso Bellacosa
  • NOVEL GENE ENCODING A DNA REPAIR ENZYME AND METHODS OF USE THEREOF
    Publication number: 20080090763
    Abstract: An isolated nucleic acid molecule encoding a human DNA repair enzyme, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids, proteins and antibodies thereto may be used to advantage in genetic or cancer screening assays. MED1, which recognizes and cleaves DNA, may also be used for the diagnostic detection of mutations and genetic variants.
    Type: Application
    Filed: April 24, 2007
    Publication date: April 17, 2008
    Inventor: Alfonso Bellacosa
  • Antibodies immunologically specific for a DNA repair endonuclease and methods of use thereof
    Patent number: 7208583
    Abstract: An isolated nucleic acid molecule encoding a human DNA repair enzyme, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids, proteins and antibodies thereto may be used to advantage in genetic or cancer screening assays. MED1, which recognizes and cleaves DNA, may also be used for the diagnostic detection of mutations and genetic variants.
    Type: Grant
    Filed: July 29, 2003
    Date of Patent: April 24, 2007
    Assignee: Fox Chase Cancer Center
    Inventor: Alfonso Bellacosa
  • Antibodies immunologically specific for a DNA repair endonuclease and methods of use thereof
    Publication number: 20040018550
    Abstract: An isolated nucleic acid molecule encoding a human DNA repair enzyme, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids, proteins and antibodies thereto may be used to advantage in genetic or cancer screening assays.
    Type: Application
    Filed: July 29, 2003
    Publication date: January 29, 2004
    Inventor: Alfonso Bellacosa
  • Methods for detection of transition single-nucleotide polymorphisms
    Patent number: 6599700
    Abstract: An isolated nucleic acid molecule encoding a human DNA repair enzyme, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids, proteins and antibodies thereto may be used to advantage in genetic or cancer screening assays. MED1, which recognizes and cleaves DNA, may also be used for the diagnostic detection of mutations and genetic variants.
    Type: Grant
    Filed: July 31, 2000
    Date of Patent: July 29, 2003
    Assignee: Fox Chase Cancer Center
    Inventor: Alfonso Bellacosa