Patents by Inventor Alfonso Nardelli

Alfonso Nardelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the preparation of (S)-2-acetyloxypropionic acid and derivatives thereof
    Patent number: 10738000
    Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: August 11, 2020
    Assignee: Bracco Imaging SpA
    Inventors: Roberta Fretta, Pietro Delogu, Fernanda Di Giorgio, Alfonso Nardelli, Stefano Sguassero, Carlo Felice Viscardi
  • METHOD FOR THE PREPARATION OF (S)-2-ACETYLOXYPROPIONIC ACID AND DERIVATIVES THEREOF
    Publication number: 20190225570
    Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
    Type: Application
    Filed: February 14, 2019
    Publication date: July 25, 2019
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Roberta FRETTA, Pietro DELOGU, Fernanda DI GIORGIO, Alfonso NARDELLI, Stefano SGUASSERO, Carlo Felice VISCARDI
  • Method for the preparation of (S)-2-acetyloxypropionic acid and derivatives thereof
    Patent number: 10246400
    Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: April 2, 2019
    Assignee: Bracco Imaging S.P.A.
    Inventors: Roberta Fretta, Pietro Delogu, Fernanda Di Giorgio, Alfonso Nardelli, Stefano Sguassero, Carlo Felice Viscardi
  • METHOD FOR THE PREPARATION OF (S)-2-ACETYLOXYPROPIONIC ACID AND DERIVATIVES THEREOF
    Publication number: 20180222840
    Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
    Type: Application
    Filed: April 5, 2018
    Publication date: August 9, 2018
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Roberta FRETTA, Pietro DELOGU, Fernanda DI GIORGIO, Alfonso NARDELLI, Stefano SGUASSERO, Carlo Felice VISCARDI
  • Method for the preparation of (S)-2-acetyloxypropionic acid and derivatives thereof
    Patent number: 9963416
    Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: May 8, 2018
    Assignee: Bracco Imaging S.P.A.
    Inventors: Roberta Fretta, Pietro Delogu, Fernanda Di Giorgio, Alfonso Nardelli, Stefano Sguassero, Carlo Felice Viscardi
  • Continuous process for the preparation of (S)-2-acetyloxypropionic acid chloride
    Patent number: 9926257
    Abstract: The present invention relates to a continuous method for the preparation of (S)-2-acetyloxypropionic acid from an aqueous solution of lactic acid and acetic anhydride, in acetic acid. (S)-2-acetyloxypropionic acid is used for the preparation of (S)-2-acetyloxypropionic acid chloride, an essential intermediate compound for the preparation of lopamidol and has to be industrially produced with high purity and suitable quality for producing lopamidol according to the Pharmacopoeia requirements. The continuous process according to the invention, comprises therefore also the chlorination steps of (S)-2-acetyloxypropionic acid with thionyl chloride to give the corresponding (S)-2-acetyloxypropionic acid chloride which is further distilled to give the suitable purity characteristics for its use for the preparation of non-ionic iodinated contrast agents as lopamidol.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: March 27, 2018
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvia Ceragioli, Pietro Delogu, Armando Mortillaro, Alfonso Nardelli, Stefano Sguassero, Rosario Velardi, Carlo Felice Viscardi
  • METHOD FOR THE PREPARATION OF (S)-2-ACETYLOXYPROPIONIC ACID AND DERIVATIVES THEREOF
    Publication number: 20170210692
    Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
    Type: Application
    Filed: June 10, 2015
    Publication date: July 27, 2017
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Roberta FRETTA, Pietro DELOGU, Fernanda DI GIORGIO, Alfonso NARDELLI, Stefano SGUASSERO, Carlo Felice VISCARDI
  • CONTINUOUS PROCESS FOR THE PREPARATION OF (S)-2-ACETYLOXYPROPIONIC ACID CHLORIDE
    Publication number: 20150329464
    Abstract: The present invention relates to a continuous method for the preparation of (S)-2-acetyloxypropionic acid from an aqueous solution of lactic acid and acetic anhydride, in acetic acid. (S)-2-acetyloxypropionic acid is used for the preparation of (S)-2-acetyloxypropionic acid chloride, an essential intermediate compound for the preparation of lopamidol and has to be industrially produced with high purity and suitable quality for producing lopamidol according to the Pharmacopoeia requirements. The continuous process according to the invention, comprises therefore also the chlorination steps of (S)-2-acetyloxypropionic acid with thionyl chloride to give the corresponding (S)-2-acetyloxypropionic acid chloride which is further distilled to give the suitable purity characteristics for its use for the preparation of non-ionic iodinated contrast agents as lopamidol.
    Type: Application
    Filed: December 4, 2013
    Publication date: November 19, 2015
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvia CERAGIOLI, Pietro DELOGU, Armando MORTILLARO, Alfonso NARDELLI, Stefano SGUASSERO, Rosario VELARDI, Carlo Felice VISCARDI
  • Process for the preparation of a iodinating agent
    Patent number: 9157156
    Abstract: The present invention describes a process for the synthesis of a iodinating agent, being said iodinating agent iodine chloride (ICI.) In particular, the present invention relates to a process for the electrochemical preparation of ICI, as a useful iodinating agent in the preparation of iodinated organic compounds for use as contrast agents or their precursors in the synthesis of the same.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: October 13, 2015
    Assignee: Bracco Imaging S.P.A.
    Inventors: Pier Lucio Anelli, Carlo Felice Viscardi, Pietro Delogu, Fabrizio Goffredi, Alfonso Nardelli, Giovanni Battista Giovenzana
  • PROCESS FOR THE PREPARATION OF A IODINATING AGEN
    Publication number: 20120088926
    Abstract: The present invention describes a process for the synthesis of a iodinating agent, being said iodinating agent iodine chloride (ICI.) In particular, the present invention relates to a process for the electrochemical preparation of ICI, as a useful iodinating agent in the preparation of iodinated organic compounds for use as contrast agents or their precursors in the synthesis of the same.
    Type: Application
    Filed: July 6, 2010
    Publication date: April 12, 2012
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Pier Lucio Anelli, Carlo Felice Viscardi, Pietro Delogu, Fabrizio Goffredi, Alfonso Nardelli, Giovanni Battista Giovenzana
  • Process for producing an omega-functionalized aliphatic carboxylic acid and intermediate products of said process, including 2-oxepanone-7-substituted products
    Patent number: 5917067
    Abstract: A process for producing an omega-functionalized aliphatic carboxylic acid starting from cyclohexanone and omega-functionalized .alpha.-olefins or acrylic esters. The process comprises an addition step, an oxidation step, an isomerization step, and one or more hydrogenation steps. The process allows to use raw materials that are available at low cost and to achieve high selectivity and high yield with industrially simple steps. The process includes the production of new intermediate products, including 2-oxepanone-7-substituted products.
    Type: Grant
    Filed: April 18, 1996
    Date of Patent: June 29, 1999
    Assignee: Industrie Chimiche Caffaro S.P.A.
    Inventors: Livius Cotarca, Paolo Maggioni, Alfonso Nardelli, Stefano Sguassero
  • Process for producing an omega-functionalized aliphatic carboxylic acid and intermediate products of said process
    Patent number: 5872267
    Abstract: A process for producing an omega-functionalized aliphatic carboxylic acid starting from cyclohexanone and omega-functionalized .alpha.-olefins. The process comprises an addition step, an oxidation step, an isomerization step, one or more hydrogenation steps and hydrolysis. The process allows to use raw materials that are available at low cost and to achieve high selectivity and high yield with industrially simple steps. The process includes the production of new intermediate products.
    Type: Grant
    Filed: April 16, 1996
    Date of Patent: February 16, 1999
    Assignee: Industrie Chimiche Caffaro, S.p.A.
    Inventors: Livius Cotarca, Paolo Maggioni, Alfonso Nardelli