Patents by Inventor Alfred Boris

Alfred Boris has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating disease states by the administration of 1.alpha.,25,26-trihydroxycholecalciferol
    Patent number: 4617297
    Abstract: The present invention relates to the method of treating disease states characterized by higher than normal levels of endogenously produced 1.alpha.,25 dihydroxy-cholecalciferol or conditions where there is an increased sensitivity to 1.alpha., 25 dihydroxy-cholecalciferol by administering to an organism suffering from such a disease state a pharmaceutically effective amount of the R or S epimer of 1.alpha.,25,26 trihydroxy-cholecalciferol.
    Type: Grant
    Filed: April 3, 1984
    Date of Patent: October 14, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alfred Boris, John J. Partridge, Milan R. Uskokovic
  • Method of treating milk fever
    Patent number: 4599330
    Abstract: The present invention relates to a method of preventing milk fever which comprises administering to a preparturient female ruminant an effective amount of 24,24-difluoro-1.alpha.,25-dihydroxycholecalciferol.
    Type: Grant
    Filed: May 17, 1982
    Date of Patent: July 8, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alfred Boris, John J. Partridge, Milan R. Uskokovic
  • 4-(8-bromodibenz[b,f]oxepin-10-yl)-1,2,3,6-tetrahydro-1-methylpyridine and 4-(2-bromodibenzo[a,d]cyclophetatriene-11-yl)-1,2,3,6-tetrahydro-1-methy lpyridine for dermal inflammation
    Patent number: 4595689
    Abstract: A method of treating inflammation which comprises topically administering to the affected area a compound of the formula ##STR1## or a pharmaceutically acceptable addition salt thereof, is described.
    Type: Grant
    Filed: February 9, 1984
    Date of Patent: June 17, 1986
    Assignee: Hoffmann-LaRoche Inc.
    Inventors: Alfred Boris, Robert W. Guthrie, Richard W. Kierstead
  • Synthesis of 1.alpha.,25-dihydroxyergocalciferol
    Patent number: 4595776
    Abstract: The invention is directed to a process and intermediates for the preparation of 1.alpha.,25-dihydroxyergocalciferol as well as substantially pure and crystalline 1.alpha.,25-dihydroxyergocolciferol. The end-product 1.alpha.,25-dihydroxyergocalciferol is useful in the treatment of disease states which are characterized by insufficient amounts of 1.alpha., 25-dihydroxycholecalciferol.
    Type: Grant
    Filed: December 17, 1984
    Date of Patent: June 17, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico G. Baggiolini, Andrew D. Batcho, Alfred Boris, Milan R. Uskokovic
  • Therapeutic compositions for reducing sebum secretion
    Patent number: 4588750
    Abstract: This invention is directed to methods for and compositions useful in reducing sebum secretion utilizing 1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-[.alpha.-methylstyryl]naphthalene as an active ingredient.
    Type: Grant
    Filed: April 25, 1983
    Date of Patent: May 13, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Alfred Boris
  • Synthesis of 1.alpha.,25-dihydroxyergocalciferol
    Patent number: 4508651
    Abstract: The invention is directed to a process and intermediates for the preparation of 1.alpha.,25-dihydroxyergocalciferol as well as substantially pure and crystalline 1.alpha.,25-dihydroxyergocolciferol. The end-product 1.alpha.,25-dihydroxyergocalciferol is useful in the treatment of disease states which are characterized by insufficient amounts of 1.alpha.,25-dihydroxycholecalciferol.
    Type: Grant
    Filed: March 21, 1983
    Date of Patent: April 2, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico G. Baggiolini, Andrew D. Batcho, Alfred Boris, Milan R. Uskokovic
  • Method of treatment
    Patent number: 4397847
    Abstract: The present invention relates to a method of treating osteoporosis by administering to a host suffering from osteoporosis an effective amount of 24,24-difluoro-1.alpha.,25-dihydroxycholecalciferol.
    Type: Grant
    Filed: May 17, 1982
    Date of Patent: August 9, 1983
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alfred Boris, John J. Partridge, Milan R. Uskokovic
  • Oral male antifertility method and compositions
    Patent number: 3934015
    Abstract: A class of substituted 2-cycloalkylaminoalkylphenols, preferably D,L-6-(N-.alpha.-pipecolinomethyl)-5-hydroxyindane, enantiomers thereof and acid addition salts thereof have been found to exhibit oral antifertility activity in male aves and mammals. These compounds may therefore be utilized to induce temporary or non-reversible sterility in treated subjects.
    Type: Grant
    Filed: November 5, 1970
    Date of Patent: January 20, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Alfred Boris