Patents by Inventor Alfred Tonelli

Alfred Tonelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Enhancing Protection Against Organ and Vascular Injury, Hematopoietic Recovery and Survival in Response to Total Body Radiation/Chemical Exposure
    Publication number: 20220168392
    Abstract: Methods of mitigating vascular injury, promoting organ and hematopoietic recovery, accelerating vascular recovery, and enhancing survival in a subject treated with radiation therapy or chemotherapy are described. In particular, an effective amount of a thrombopoietin (TPO) mimetic, such as RWJ-800088, is used at the appropriate times relative to the Total Body Irradiation or Chemotherapy exposure to achieve these prophylactic and/or therapeutic benefits.
    Type: Application
    Filed: February 18, 2022
    Publication date: June 2, 2022
    Inventors: Gary Eichenbaum, Sanchita Ghosh, Alfred Tonelli
  • METHODS OF ENHANCING PROTECTION AGAINST ORGAN AND VASCULAR INJURY, HEMATOPOIETIC RECOVERY AND SURVIVAL IN RESPONSE TO TOTAL BODY RADIATION/CHEMICAL EXPOSURE
    Publication number: 20200237872
    Abstract: Methods of mitigating vascular injury, promoting organ and hematopoietic recovery, accelerating vascular recovery, and enhancing survival in a subject treated with radiation therapy or chemotherapy are described. In particular, an effective amount of a thrombopoietin (TPO) mimetic, such as RWJ-800088, is used at the appropriate times relative to the Total Body Irradiation or Chemotherapy exposure to achieve these prophylactic and/or therapeutic benefits.
    Type: Application
    Filed: January 24, 2020
    Publication date: July 30, 2020
    Inventors: Gary EICHENBAUM, Sanchita GHOSH, Alfred TONELLI
  • METHODS OF PROTECTING VASCULAR INTEGRITY INDUCED BY TARGETED RADIATION THERAPY
    Publication number: 20200164039
    Abstract: Methods of protecting vascular integrity in a subject exposed to a targeted radiation therapy are described. In particular, an effective amount of a thrombopoietin (TPO) mimetic, such as TPOm, is used to protect vascular integrity following the radiation therapy.
    Type: Application
    Filed: July 26, 2018
    Publication date: May 28, 2020
    Inventors: Gary EICHENBAUM, Alfred TONELLI
  • CONTROLLED RELEASE HYDROCODONE FORMULATIONS
    Publication number: 20190022086
    Abstract: A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12/Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.
    Type: Application
    Filed: July 31, 2018
    Publication date: January 24, 2019
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John Masselink, Alfred Tonelli
  • CONTROLLED RELEASE HYDROCODONE FORMULATIONS
    Publication number: 20180353502
    Abstract: A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release material.
    Type: Application
    Filed: June 13, 2018
    Publication date: December 13, 2018
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John K. Masselink, Alfred Tonelli
  • Methods of manufacturing oral dosage forms
    Patent number: 10076516
    Abstract: A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12/Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: September 18, 2018
    Assignee: Purdue Pharma L.P.
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John Masselink, Alfred Tonelli
  • Methods of manufacturing oral formulations
    Patent number: 10022368
    Abstract: A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release material.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: July 17, 2018
    Assignee: Purdue Pharma L.P.
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John K Masselink, Alfred Tonelli
  • Methods of providing analgesia
    Patent number: 9682077
    Abstract: A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release material.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: June 20, 2017
    Assignee: PURDUE PHARMA L.P.
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John K Masselink, Alfred Tonelli
  • Methods of providing analgesia
    Patent number: 9675611
    Abstract: A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12/Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: June 13, 2017
    Assignee: Purdue Pharma L.P.
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John Masselink, Alfred Tonelli
  • Controlled release hydrocodone formulations
    Patent number: 9669023
    Abstract: A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release material.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: June 6, 2017
    Assignee: PURDUE PHARMA L.P.
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John K Masselink, Alfred Tonelli
  • Controlled release hydrocodone formulations
    Patent number: 9669024
    Abstract: A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12/Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: June 6, 2017
    Assignee: Purdue Pharma L.P.
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John Masselink, Alfred Tonelli
  • Controlled release hydrocodone formulations
    Patent number: 9669022
    Abstract: A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12/Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: June 6, 2017
    Assignee: Purdue Pharma L.P.
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John Masselink, Alfred Tonelli
  • METHODS OF MANUFACTURING ORAL FORMULATIONS
    Publication number: 20170151229
    Abstract: A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release material.
    Type: Application
    Filed: December 13, 2016
    Publication date: June 1, 2017
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John K. Masselink, Alfred Tonelli
  • METHODS OF PROVIDING ANALGESIA
    Publication number: 20170143697
    Abstract: A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12/Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.
    Type: Application
    Filed: December 13, 2016
    Publication date: May 25, 2017
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John Masselink, Alfred Tonelli
  • METHODS OF MANUFACTURING ORAL DOSAGE FORMS
    Publication number: 20170136006
    Abstract: A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12/Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.
    Type: Application
    Filed: December 13, 2016
    Publication date: May 18, 2017
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John Masselink, Alfred Tonelli
  • CONTROLLED RELEASE HYDROCODONE FORMULATIONS
    Publication number: 20170087153
    Abstract: A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12/Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.
    Type: Application
    Filed: December 13, 2016
    Publication date: March 30, 2017
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John Masselink, Alfred Tonelli
  • METHODS OF PROVIDING ANALGESIA
    Publication number: 20170087152
    Abstract: A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release material.
    Type: Application
    Filed: December 13, 2016
    Publication date: March 30, 2017
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John K. Masselink, Alfred Tonelli
  • CONTROLLED RELEASE HYDROCODONE FORMULATIONS
    Publication number: 20170087151
    Abstract: A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release material.
    Type: Application
    Filed: December 13, 2016
    Publication date: March 30, 2017
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John K. Masselink, Alfred Tonelli
  • Controlled release hydrocodone formulations
    Patent number: 9572805
    Abstract: A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release material.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: February 21, 2017
    Assignee: Purdue Pharma L.P.
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John K. Masselink, Alfred Tonelli
  • Controlled release hydrocodone formulations
    Patent number: 9572804
    Abstract: A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release material.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: February 21, 2017
    Assignee: Purdue Pharma L.P.
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John K. Masselink, Alfred Tonelli