Patents by Inventor Alfredo Giuseppe Tomasselli

Alfredo Giuseppe Tomasselli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of producing catalytically active BACE2 enzymes
    Publication number: 20090081731
    Abstract: The invention provides methods and compositions for the efficient expression and isolation of BACE2 polypeptides from inclusion bodies and its refolding to an active enzyme.
    Type: Application
    Filed: June 17, 2008
    Publication date: March 26, 2009
    Inventors: Alfredo Giuseppe Tomasselli, Thomas Lowell Emmons, Ana Maria Mildner Lallana
  • Mutant presenilin 1 polypeptides
    Patent number: 6686449
    Abstract: The present invention provides mutant presenilin 1 and presenilin 2 polpeptides and polynucleotides encoding the polypeptides and methods for their production by recombinant and PCR techniques are disclosed. Methods for utilizing the mutant polypeptides in screens for inhibitors of activity are also disclosed.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: February 3, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Donald Bainbridge Carter, Alfredo Giuseppe Tomasselli
  • Mutant presenilin 1 and presenilin 2 polypeptides
    Publication number: 20030065141
    Abstract: The present invention provides mutant presenilin 1 and presenilin 2 polpeptides and polynucleotides encoding the polypeptides and methods for their production by recombinant and PCR techniques are disclosed. Methods for utilizing the mutant polypeptides in screens for inhibitors of activity are also disclosed.
    Type: Application
    Filed: June 29, 2001
    Publication date: April 3, 2003
    Inventors: Donald Bainbridge Carter, Alfredo Giuseppe Tomasselli
  • Method for autoactivation of procaspase 8
    Publication number: 20020045205
    Abstract: A novel recombinant procaspase 8 protein lacking the death effector domains and a method for converting said novel procaspase protein to full active human caspase 8 by concentration of the procaspase 8 on a collection device.
    Type: Application
    Filed: May 22, 2001
    Publication date: April 18, 2002
    Inventors: Robert Leroy Heinrikson, Alfredo Giuseppe Tomasselli, Kenneth A. Koeplinger
  • Method for autoactivation of procaspase 8
    Patent number: 6303329
    Abstract: A novel recombinant procaspase 8 protein lacking the death effector domains and a method for converting said novel procaspase protein to full active human caspase 8 by concentration of the procaspase 8 on a collection device.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: October 16, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventors: Robert Leroy Heinrikson, Alfredo Giuseppe Tomasselli, Kenneth A. Koeplinger