Patents by Inventor Alfredo Hernandez
Alfredo Hernandez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11008295Abstract: The invention relates to novel compounds and their use in medicine, particularly in treating and/or preventing infections caused by a bacterium, fungus or virus or in treating and/or preventing cancer. Additionally, the invention relates to a process for obtaining the compounds of the invention.Type: GrantFiled: April 25, 2018Date of Patent: May 18, 2021Assignee: HORITZONTS TECNOLOGICS HUNGARY KORLÁTOLT FELELOSSÉGU TÁRSASÁGInventors: Alfredo Hernández Cabanillas, Santiago Maderuelo Corral, Montserrat Ortega Doménech, Diego Fernando Rosero Valencia, Ángel Rumbero Sánchez, Victor Tena Pérez
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Publication number: 20200316082Abstract: The invention relates to the use of 1-(4,6-dipentyl-5,6-dihydro-2H-1,2,3-oxadiazin-2-yl)-3-hydroxypropan-1-one in treating and/or preventing infections caused by a bacterium, fungus or virus or in treating and/or preventing cancer. Additionally, the invention relates to a process for obtaining the compound of formula (I) of the invention, said process comprising the steps of cultivating a strain of Dolichospermum sp in an aqueous nutrient medium with assimilable carbon and nitrogen sources and salts, under controlled aerobic conditions, and then recovering the compound of general formula (I) from the culture broth.Type: ApplicationFiled: December 29, 2016Publication date: October 8, 2020Inventors: Ana María GONZÁLEZ FUENTE, Alfredo HERNÁNDEZ CABANILLAS, Santiago MADERUELO CORRAL, Montserrat ORTEGA DOMÉNECH, Diego Fernando ROSERO VALENCIA, Ángel RUMBERO SÁNCHEZ, Victor TENA PÉREZ
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Publication number: 20200190044Abstract: The invention relates to novel compounds and their use in medicine, particularly in treating and/or preventing infections caused by a bacterium, fungus or virus or in treating and/or preventing cancer. Additionally, the invention relates to a process for obtaining the compounds of the invention.Type: ApplicationFiled: April 25, 2018Publication date: June 18, 2020Inventors: Alfredo HERNÁNDEZ CABANILLAS, Santiago MADERUELO CORRAL, Montserrat ORTEGA DOMÉNECH, Diego Fernando ROSERO VALENCIA, Ángel RUMBERO SÁNCHEZ, Victor TENA PÉREZ
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Patent number: 10307328Abstract: A device for treating sleep apnea by discriminating between successive sleep stages of a patient includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, a sensor configured to measure a biological parameter of the patient, and a controller. The controller is configured to determine a state of the patient based on the biological parameter, perform a sleep analysis based on the state of the patient, activate the generator to trigger production of the stimulation pulses, determine a variation of the biological parameter subsequent to the production of the stimulation pulses, determine a response of the patient to the stimulation pulses according to the variation of the biological parameter, and determine a sleep stage of the patient based on the response.Type: GrantFiled: February 9, 2015Date of Patent: June 4, 2019Assignees: SORIN CRM SAS, UNIVERSITE JOSEPH FOURIER—GRENOBLE 1, INSERM—INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITÉ RENNES 1Inventors: Laurence Graindorge, Amel Amblard, Christine Henry, Marcel Limousin, Laure Duchemin Laporte, Alfredo Hernandez, Jean-Louis Pépin
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Patent number: 10299984Abstract: A system includes a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a cessation of the respiratory disorder. The processor is further configured to extend the stimulation control signals for a determined duration following the cessation of the respiratory disorder.Type: GrantFiled: December 7, 2015Date of Patent: May 28, 2019Assignees: SORIN CRM SAS, INSERM-INSTITUT DE LA RECHERCHE MÉDICALE, UNIVERSITÉ JOSEPH FOURIER, UNIVERSITÉ DE RENNES 1Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
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Patent number: 10292897Abstract: A system includes a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a disappearance of the respiratory disorder. The processor is further configured to determine a therapy by selecting a stimulation strategy among several stimulation strategies according to a type of expected or detected disorder.Type: GrantFiled: December 7, 2015Date of Patent: May 21, 2019Assignees: SORIN CRM SAS, INSERM—INSTITUT DE LA RECHERCHE MÉDICALE, UNIVERSITÉ JOSEPH FOURIER, UNIVERSITÉ DE RENNES 1Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
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Patent number: 10292898Abstract: A device includes a processor configured to detect a respiratory disorder episode and generate kinesthetic stimulation control signals in response to the detection of a respiratory disorder episode. The device further includes at least one kinesthetic effector adapted to be applied to a patient's outer skin site and includes a vibrating electromechanical transducer capable of receiving stimulation control signals and outputting a kinesthetic stimulation energy determined by the stimulation control signals. The processor is further configured to determine the effectiveness of stimulation by detecting a cessation of the respiratory disorder episode. The processor is further configured to determine a stimulation energy by selecting an initial energy value and varying the energy value as a function of the effectiveness of previous stimulation.Type: GrantFiled: December 7, 2015Date of Patent: May 21, 2019Assignees: SORIN CRM SAS, INSERM-INSTITUT DE LA RECHERCHE MÉDICALE, UNIVERSITÉ JOSEPH FOURIER, UNIVERSITÉDE RENNES 1Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
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Publication number: 20190126048Abstract: An active implantable medical device for neurostimulation therapy is disclosed. The device produces stimulation pulse sequences generated continuously in succession during activity periods separated by intermediate inactivity periods during which no stimulation is issued. An input signal, provided by a physiological sensor, representative of cardiac activity and/or of the patient's hemodynamic status is received by circuitry. The circuitry further provides for dynamic control of the neurostimulation therapy, wherein the length of activity periods is modulated based on the current value level of the control parameter compared to a threshold. The duration of the next period of inactivity is calculated by the circuitry at the end of each activity period to maintain a constant duty cycle ratio between periods of activity and periods of inactivity.Type: ApplicationFiled: December 21, 2018Publication date: May 2, 2019Applicants: SORIN CRM SAS, UNIVERSITÉ DE RENNES 1, INSERM - INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALEInventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero
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Patent number: 10251809Abstract: A device for treating sleep apnea in a patient through stimulation. The device includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, and a controller. The controller is configured to determine a sleep state of the patient, adaptively control the generator based on the sleep state where the sleep state includes a plurality of sleep stages, and modulate a stimulation energy of the stimulation pulses produced by the generator based on the sleep stage of the patient.Type: GrantFiled: February 9, 2015Date of Patent: April 9, 2019Assignees: Sorin CRM SAS, INSERM—INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITÉ DE RENNES 1, UNIVERSITE JOSEPH FOURIER—GRENOBLE 1Inventors: Laurence Graindorge, Amel Amblard, Christine Henry, Marcel Limousin, Laure Duchemin Laporte, Alfredo Hernandez, Jean-Louis Pépin
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Publication number: 20190091476Abstract: A treatment system for stimulating the vagus nerves is described, comprising the following elements: -a detection and control unit (20); -at least one detection probe (10d, 10g) connected to the detection and control unit and intended to be applied to at least one of the two vagus nerves of a patient; -means (24) provided in the detection and control unit for detecting a phenomenon of mass discharge of action potentials in at least one vagus nerve using the detection probe or detection probes; -stimulation probes (10d, 10g) for stimulating vagus nerves, and -means (24) provided in the detection and control unit that are capable, in response to the detection of a mass discharge, of applying predefined asymmetric stimulation signals to said stimulation probes capable of causing a depolarization and/or hyperpolarization of the vagus nerves and of blocking the conduction of the action potentials at least in the efferent direction.Type: ApplicationFiled: February 13, 2017Publication date: March 28, 2019Inventors: Alfredo HERNANDEZ, Benoit MARTIN, Arnaud BIRABEN
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Patent number: 10166393Abstract: The invention relates to an active implantable medical device. The device includes a VNS pulse generator, an activity sensor for detecting a patient's current activity level, and a processor. The processor is configured to collect the electrical activity of the heart, such as a current intrinsic heart rate of the patient. The processor further calculates values of a reference heart rate based on the patient's current activity level. A first histogram is constructed from the reference heart rate values, and a second histogram is constructed from the intrinsic heart rate values. An index representative of the patient's condition is derived by comparing the first and second histograms.Type: GrantFiled: October 14, 2015Date of Patent: January 1, 2019Assignees: SORIN CRM SAS, UNIVERSITÉ DE RENNES 1Inventors: Jean-Luc Bonnet, Mélanie Mullemeester, Alfredo Hernandez, Guy Carrault
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Patent number: 10159840Abstract: An active implantable medical device for neurostimulation therapy is disclosed. The device produces stimulation pulse sequences generated continuously in succession during activity periods separated by intermediate inactivity periods during which no stimulation is issued. An input signal, provided by a physiological sensor, representative of cardiac activity and/or of the patient's hemodynamic status is received by circuitry. The circuitry further provides for dynamic control of the neurostimulation therapy, wherein the length of activity periods is modulated based on the current value level of the control parameter compared to a threshold. The duration of the next period of inactivity is calculated by the circuitry at the end of each activity period to maintain a constant duty cycle ratio between periods of activity and periods of inactivity.Type: GrantFiled: July 22, 2015Date of Patent: December 25, 2018Assignees: SORIN CRM SAS, UNIVERSITÉ DE RENNES 1, INSERM-INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALEInventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero
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Patent number: 10124173Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.Type: GrantFiled: June 28, 2016Date of Patent: November 13, 2018Assignees: SORIN CRM SAS, UNIVERSITE DE RENNES 1, INSERM- INSTITUT DE LA RECHERCHE MEDICALEInventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero, Virginie Le Rolle
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Patent number: 10099056Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.Type: GrantFiled: June 28, 2016Date of Patent: October 16, 2018Assignees: Sorin CRM SAS, UNIVERSITE DE RENNES 1, INSERM—INSTITUT DE LA RECHERCHE MEDICALEInventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero, Virginie Le Rolle
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Patent number: 10092756Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to rules on the physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.Type: GrantFiled: June 28, 2016Date of Patent: October 9, 2018Assignees: SORIN CRM SAS, UNIVERSITE DE RENNES 1, INSERM—INSTITUT DE LA RECHERCHE MEDICALEInventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero, Virginie Le Rolle
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Publication number: 20180271452Abstract: The invention relates to an active implantable medical device comprising a processing unit able to be alternately operated during a predetermined period of activity and on standby during a standby period in a cyclical manner, and means for acquiring data relating to physiological and/or physical activity. The device also comprises means for calculating a frequency analysis of the data acquired, said calculating means being capable of successively perform part of the frequency analysis during periods of activity of the processing unit.Type: ApplicationFiled: September 30, 2016Publication date: September 27, 2018Inventors: Jean-Luc Bonnet, Thomas Herrmann, Christine Henry, Alfredo Hernandez, Guy Carrault
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Patent number: 9981132Abstract: One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.Type: GrantFiled: June 28, 2016Date of Patent: May 29, 2018Assignees: SORIN CRM SAS, UNIVERSITE DE RENNES 1, INSERM—INSTITUT DE LA RECHERCHE MEDICALEInventors: Jean-Luc Bonnet, Alfredo Hernandez, Guy Carrault, Hector Romero, Virginie Le Rolle
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Publication number: 20170326024Abstract: A vibrotactile stimulation device intended to be applied against a body environment (MC) to be stimulated and comprising a vibrating effector suitable for applying, to said environment, pulses of mechanical vibrational energy, and a controller controlling the effector according to stimulation rules. The device is remarkable in that it further comprises vibration detector suitable for being exposed to the body environment in order to receive a part of the vibrational energy transmitted to said means by said environment during the application of the pulses of vibrational energy, and determine a transmission characteristic of the vibrational energy between the effector and the environment to be stimulated, said vibration detector being linked to the controller. An application to improving the efficacy of body stimulation in combating sleep apnoea is also disclosed.Type: ApplicationFiled: November 24, 2015Publication date: November 16, 2017Applicants: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE DE RENNES IInventor: Alfredo HERNANDEZ
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Publication number: 20170326025Abstract: A vibrotactile stimulation device intended to be applied against a body medium (MC) to be stimulated, produced in the form of a functional unit, comprising a vibrating effector suitable for applying, to said medium, pulses of mechanical vibrational energy, and a controller for controlling the effector according to stimulation rules. The functional unit further houses a first electrode suitable for cooperating with at least one second electrode separated from the first electrode in order to supply signals representative of a cardiac activity and a muscular activity on the medium to be stimulated, said controller being sensitive to cardiac activity and muscular activity signals in order to influence the stimulation. The stimulation device may be used for body stimulation in combating sleep apnea, with improved detection.Type: ApplicationFiled: November 24, 2015Publication date: November 16, 2017Applicants: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE DE RENNES IInventor: Alfredo HERNANDEZ
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Patent number: 9782117Abstract: A system for assessing a sympathovagal balance of a patient includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and outputs a stimulation energy, a sensor configured to measure a physiological signal, and a processor. The processor is configured to control the generator during a plurality of sequences to produce the stimulation pulses over a test period, determine a biological parameter of a current activity of the patient derived from the physiological signal, determine a variation of the biological parameter resulting from the stimulation pulses, and determine a sympathovagal balance index according to the variation in the biological parameter.Type: GrantFiled: February 9, 2015Date of Patent: October 10, 2017Assignees: SORIN CRM SAS, UNIVERSITÉ DE RENNES 1Inventors: Jean-Luc Bonnet, Alfredo Hernandez