Patents by Inventor Alfredo Lopez De Leon

Alfredo Lopez De Leon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods For Increasing The Productivity Of A Filamentous Fungal Cell In The Production Of A Polypeptide
    Publication number: 20220064228
    Abstract: The present invention relates to a mutant of a parent filamentous fungal cell, comprising a coding sequence of a polypeptide of interest under the transcriptional control of a promoter regulated by a transcription factor, wherein the gene encoding the transcription factor is modified in the parent filamentous fungal cell to produce the mutant rendering the mutant deficient in the production of the transcription factor, which increases the productivity of the mutant in the production of the polypeptide of interest, and/or reduces or eliminates the cellulase-negative phenotype in the resulting mutant. The present invention also relates to a method for constructing such a mutant and a method of producing a polypeptide of interest with such a mutant.
    Type: Application
    Filed: December 12, 2019
    Publication date: March 3, 2022
    Applicant: Novozymes A/S
    Inventors: Suchindra Maiyuran, Alfredo Lopez De Leon
  • Polypeptides Having Cellulolytic Enhancing Activity And Nucleic Acids Encoding Same
    Publication number: 20200148730
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Application
    Filed: December 17, 2019
    Publication date: May 14, 2020
    Applicant: Novozymes, Inc.
    Inventors: Kimberly Brown, Paul Harris, Elizabeth Zaretsky, Edward Re, Elena Vlasenko, Keith McFarland, Alfredo Lopez de Leon
  • Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same
    Patent number: 10544195
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: January 28, 2020
    Assignee: Novozymes, Inc.
    Inventors: Kimberly Brown, Paul Harris, Elizabeth Zaretsky, Edward Re, Elena Vlasenko, Keith McFarland, Alfredo Lopez de Leon
  • Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same
    Patent number: 10280201
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: May 7, 2019
    Assignee: Novozymes, Inc.
    Inventors: Kimberly Brown, Paul Harris, Elizabeth Zaretsky, Edward Re, Elena Vlasenko, Keith McFarland, Alfredo Lopez de Leon
  • Polypeptides Having Cellulolytic Enhancing Activity And Nucleic Acids Encoding Same
    Publication number: 20190023751
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Application
    Filed: October 10, 2018
    Publication date: January 24, 2019
    Applicant: Novozymes, Inc.
    Inventors: Kimberly Brown, Paul Harris, Elizabeth Zaretsky, Edward Re, Elena Vlasenko, Keith McFarland, Alfredo Lopez de Leon
  • Polypeptides Having Cellulolytic Enhancing Activity And Nucleic Acids Encoding Same
    Publication number: 20180072779
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Application
    Filed: August 29, 2017
    Publication date: March 15, 2018
    Applicant: Novozymes, Inc.
    Inventors: Kimberly Brown, Paul Harris, Elizabeth Zaretsky, Edward Re, Elena Vlasenko, Keith McFarland, Alfredo Lopez de Leon
  • Polypeptides having xylanase activity and polynucleotides encoding same
    Patent number: 9771569
    Abstract: The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: September 26, 2017
    Assignee: NOVOZYMES A/S
    Inventors: Alfredo Lopez de Leon, Michael Rey
  • Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same
    Patent number: 9751916
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: September 5, 2017
    Assignee: Novozymes, Inc.
    Inventors: Kimberly Brown, Paul Harris, Elizabeth Zaretsky, Edward Re, Elena Vlasenko, Keith McFarland, Alfredo Lopez de Leon
  • Polypeptides having aspartic endopeptidase activity and polynucleotides encoding same
    Patent number: 9493759
    Abstract: The present invention relates to isolated polypeptides having aspartic endopeptidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: November 15, 2016
    Assignee: Novozymes, Inc.
    Inventors: Beth Nelson, Alfredo Lopez de Leon, Michael Rey
  • Polypeptides Having Cellulolytic Enhancing Activity And Nucleic Acids Encoding Same
    Publication number: 20160289279
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Application
    Filed: June 21, 2016
    Publication date: October 6, 2016
    Inventors: Kimberly Brown, Paul Harris, Elizabeth Zaretsky, Edward Re, Elena Vlasenko, Keith McFarland, Alfredo Lopez de Leon
  • Polypeptides Having Xylanase Activity And Polynucleotides Encoding Same
    Publication number: 20160237417
    Abstract: The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: May 4, 2016
    Publication date: August 18, 2016
    Inventors: Alfredo Lopez de Leon, Michael Rey
  • Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same
    Patent number: 9410165
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: August 9, 2016
    Assignee: Novozymes, Inc.
    Inventors: Kimberly Brown, Paul Harris, Elizabeth Zaretsky, Edward Re, Elena Vlasenko, Keith McFarland, Alfredo Lopez de Leon
  • Polypeptides having xylanase activity and polynucleotides encoding same
    Patent number: 9353360
    Abstract: The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: May 31, 2016
    Assignee: Novozymes, Inc.
    Inventors: Alfredo Lopez de Leon, Michael Rey
  • Polypeptides Having Endoglucanase Activity And Polynucleotides Encoding Same
    Publication number: 20150175990
    Abstract: The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: March 9, 2015
    Publication date: June 25, 2015
    Inventors: Alfredo Lopez de Leon, Michael Rey
  • Polypeptides Having Xylanase Activity And Polynucleotides Encoding Same
    Publication number: 20150132822
    Abstract: The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: January 26, 2015
    Publication date: May 14, 2015
    Inventors: Alfredo Lopez de Leon, Michael Rey
  • Polypeptides having endoglucanase activity and polynucleotides encoding same
    Patent number: 8975059
    Abstract: The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: March 10, 2015
    Assignee: Novozymes A/S
    Inventors: Alfredo Lopez de Leon, Michael Rey
  • Polypeptides having xylanase activity and polynucleotides encoding same
    Patent number: 8940515
    Abstract: The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: January 27, 2015
    Assignee: Novozymes, Inc.
    Inventors: Alfredo Lopez de Leon, Michael Rey
  • Polypeptides Having Cellulolytic Enhancing Activity And Nucleic Acids Encoding Same
    Publication number: 20150024439
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Application
    Filed: September 29, 2014
    Publication date: January 22, 2015
    Inventors: Kimberly Brown, Paul Harris, Elizabeth Zaretsky, Edward Re, Elena Vlasenko, Keith McFarland, Alfredo Lopez de Leon
  • Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same
    Patent number: 8846888
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: September 30, 2014
    Assignee: Novozymes, Inc.
    Inventors: Kimberly Brown, Paul Harris, Elizabeth Zaretsky, Edward Re, Elena Vlasenko, Keith McFarland, Alfredo Lopez de Leon
  • Polypeptides Having Cellulolytic Enhancing Activity And Nucleic Acids Encoding Same
    Publication number: 20140093940
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
    Type: Application
    Filed: October 12, 2012
    Publication date: April 3, 2014
    Applicant: Novozymes, Inc.
    Inventors: Kimberly Brown, Paul Harris, Elizabeth Zaretsky, Edward Re, Elena Vlasenko, Keith McFarland, Alfredo Lopez de Leon