Abstract: The present invention relates to machine learning (ML) explainability (MLX). Herein are local explanation techniques for black box ML models based on coalitions of features in a dataset. In an embodiment, a computer receives a request to generate a local explanation of which coalitions of features caused an anomaly detector to detect an anomaly. During unsupervised generation of a new coalition, a first feature is randomly selected from features in a dataset. Which additional features in the dataset can join the coalition, because they have mutual information with the first feature that exceeds a threshold, is detected. For each feature that is not in the coalition, values of the feature are permuted in imperfect copies of original tuples in the dataset. An average anomaly score of the imperfect copies is measured. Based on the average anomaly score of the imperfect copies, a local explanation is generated that references (e.g. defines) the coalition.

Abstract: The present disclosure provides iPSC-derived dopaminergic neurons comprised disease-associated mutations. Further provided herein are methods for using the iPSC-derived dopaminergic neurons for the study of neuroinflammation, such as to identify novel targets, biomarkers, and therapeutic agents for the diagnosis, prognosis, and treatment of neurodegenerative diseases. Further provided herein are assays for studying neuroinflammation using the present cell culture models.

Abstract: According to the present invention there is provided a polymer comprising at least one antiseptic/analgesic/anti-inflammatory monomeric unit in conjunction with at least three further monomeric units, said three further monomeric units eliciting properties selected from the group consisting of: temperature activation, water solubility, mechanical strength, protein/polysaccharide bonding capacity, and combinations thereof. In particular, disclosed herein is a polymer, wherein the water-soluble monomeric unit is a hydrophilic ethylene glycol (OEGMA) moiety; the mechanical strength-conferring monomeric unit is polylactide-co-2-hydroxy-ethyl-methyl acrylate (PLA/HEMA); the protein-reactive monomeric unit is an N-acryloxysuccinimide (NAS) moiety; and the thermosetting monomeric unit is an N-isopropyl acrylamide (NIPAAm) moiety. The anti-septic/analgesic/anti-inflammatory monomeric unit comprises a methacrylic ester derivative of salicylic acid (5-HMA or 4-HMA, or a combination thereof).

Abstract: The present disclosure provides method for producing neural precursor cells with a glial bias from induced pluripotent cells and further differentiating the neural precursor cells to astrocytes. Further provided herein are methods for the use of the astrocytes for screening assays, models mimicking the human brain, and cell therapy.

Abstract: Compositions and methods for inducing or promoting repair of a bone fracture.

Abstract: The present disclosure provides multicellular culture models for the study of neuroinflammation, such as to identify novel targets, biomarkers, and therapeutic agents for the diagnosis, prognosis, and treatment of neurodegenerative diseases. Further provided herein are assays for studying neuroinflammation using the present cell culture models.

Abstract: The present invention provides a composition comprising a polymer and a natural or synthetic peptide or protein (NSPP). The composition forms a hydrogel with water. The composition is useful as a filler for cosmetic and therapeutic applications. Embodiments of the invention provide methods of treating certain conditions using the composition or hydrogel, and surgical kits for the simultaneous or sequential administration of the respective components of the composition, enabling the formation of the hydrogel in situ.

Abstract: According to the present invention there is provided a polymer comprising at least one antiseptic/analgesic/anti-inflammatory monomeric unit in conjunction with at least three further monomeric units, said three further monomeric units eliciting properties selected from the group consisting of temperature activation, water solubility, mechanical strength, protein/polysaccharide bonding capacity, and combinations thereof. In particular, disclosed herein is a polymer, wherein the water-soluble monomeric unit is a hydrophilic ethylene glycol (OEGMA) moiety: the mechanical strength-conferring monomeric unit is polylactide-co-2-hydroxy-ethyl-methyl acrylate (PLA/HEMA); the protein-reactive monomeric unit is an N-acryloxysuccinimide (NAS) moiety; and the thermosetting monomeric unit is an N-isopropyl acrylamide (NIPAAm) moiety. The anti-septic/analgesic/anti-inflammatory monomeric unit comprises a methacrylic ester derivative of salicylic acid (5-HMA or 4-HMA, or a combination thereof).

Abstract: According to the present invention there is provided a polymer comprising at least one antiseptic/analgesic/anti-inflammatory monomeric unit in conjunction with at least three further monomeric units, said three further monomeric units eliciting properties selected from the group consisting of: temperature activation, water solubility, mechanical strength, protein/polysaccharide bonding capacity, and combinations thereof. In particular, disclosed herein is a polymer, wherein: the water-soluble monomeric unit is a hydrophilic ethylene glycol (OEGMA) moiety; the mechanical strength-conferring monomeric unit is polylactide-co-2-hydroxy-ethyl-methyl acrylate (PLA/HEMA); the protein-reactive monomeric unit is an N-acryloxysuccinimide (NAS) moiety; and the thermosetting monomeric unit is an N-isopropyl acrylamide (NIPAAm) moiety. The anti-septic/analgesic/anti-inflammatory monomeric unit comprises a methacrylic ester derivative of salicylic acid (5-HMA or 4-HMA, or a combination thereof).

Abstract: Provided herein are methods and compositions for inducing chemical senescence in neurons and methods of using chemically induced senescent neurons for modeling neurodegenerative disease and drug discovery. The methods include contacting human neurons with a culture medium comprising an inhibitor of DNA glycosylase 1, an autophagy inhibitor, and an HIV protease inhibitor to obtain an in vitro population of senescent neurons within about 4 days. When the neurons are obtained from a patient having a neurodegenerative disease, chemically induced senescent neurons obtained by these methods recapitulate cellular and subcellular phenotypes observed in individuals with the neurodegenerative disease.

Abstract: Differential private dictionary learning privatizes input data by training an autoencoder to learn a dictionary, the autoencoder including an encoder and a decoder, and weights of channels in a layer in the decoder defining dictionary atoms forming the dictionary; inputting the input data to the trained autoencoder; projecting, using the encoder, the input data on the learned dictionary to generate a sparse representation of the input data, the sparse representation including coefficients for each dictionary atom; adding noise to the sparse representation to generate a noisy sparse representation; and mapping, using the decoder, the noisy sparse representation to a reconstructed differentially private output.

Abstract: Disclosed herein are biocompatible materials useful for tissue regeneration and repair, wherein the bioactive polymer may be in the form of a hydrogel, for example a thermoresponsive hydrogel. This bioactive polymer and a resulting hydrogel, may be used for the regeneration of bone tissue. Accordingly, also disclosed herein are methods of treating a bone defect in a mammal, the methods comprising administering a therapeutically effective amount of a hydrogel formed by the bioactive polymer to the mammal to treat the bone defect.

Abstract: Compositions and methods for inducing or promoting repair of a bone fracture.

Abstract: Compositions and methods for inducing or promoting repair of a bone fracture.

Abstract: According to the present invention there is provided a polymer comprising at least one antiseptic/analgesic/anti-inflammatory monomeric unit in conjunction with at least three further monomeric units, said three further monomeric units eliciting properties selected from the group consisting of: temperature activation, water solubility, mechanical strength, protein/polysaccharide bonding capacity, and combinations thereof. In particular, disclosed herein is a polymer, wherein: the water-soluble monomeric unit is a hydrophilic ethylene glycol (OEGMA) moiety; the mechanical strength-conferring monomeric unit is polylactide-co-2-hydroxy-ethyl-methyl acrylate (PLA/HEMA); the protein-reactive monomeric unit is an N-acryloxysuccinimide (NAS) moiety; and the thermosetting monomeric unit is an N-isopropyl acrylamide (NIPAAm) moiety. The anti-septic/analgesic/anti-inflammatory monomeric unit comprises a methacrylic ester derivative of salicylic acid (5-HMA or 4-HMA, or a combination thereof).

Abstract: A system is provided that increases the deformability of buried pipelines to accommodate combinations of vertical, lateral and longitudinal displacements and subsequent curvatures caused by ground movements. Installation of this system prevents concentration of deformations which may cause catastrophic failures such as buckling, yielding, rupture, and weld failures. The assembly includes an element provided adjacent a pipeline and collapsible in two orthogonal directions; one, the longitudinal direction of the pipe, and two, a direction of expected lateral movement of the pipe. The collapsible element is configured to resist soil pressure in a direction orthogonal to the first two directions, and further provided is a supporting backing element adjacent an end of the collapsible element opposed to the pipeline, to prevent exposure of the collapsible element to soil pressure in one of the two orthogonal collapsible directions.

Abstract: Disclosed herein are biocompatible materials useful for tissue regeneration and repair, wherein the bioactive polymer may be in the form of a hydrogel, for example a thermoresponsive hydrogel. This bioactive polymer and a resulting hydrogel, may be used for the regeneration of bone tissue. Accordingly, also disclosed herein are methods of treating a bone defect in a mammal, the methods comprising administering a therapeutically effective amount of a hydrogel formed by the bioactive polymer to the mammal to treat the bone defect.

Abstract: Compositions and methods for inducing or promoting repair of a bone fracture.

Abstract: A system is provided that increases the deformability of buried pipelines to accommodate combinations of vertical, lateral and longitudinal displacements and subsequent curvatures caused by ground movements. Installation of this system prevents concentration of deformations which may cause catastrophic failures such as buckling, yielding, rupture, and weld failures. The assembly includes an element provided adjacent a pipeline and collapsible in two orthogonal directions; one, the longitudinal direction of the pipe, and two, a direction of expected lateral movement of the pipe. The collapsible element is configured to resist soil pressure in a direction orthogonal to the first two directions, and further provided is a supporting backing element adjacent an end of the collapsible element opposed to the pipeline, to prevent exposure of the collapsible element to soil pressure in one of the two orthogonal collapsible directions.

Abstract: The present invention relates to polymers, especially polymers useful as hydrogels, and to use of hydrogels for repair or restoration of tissue. In particular, the polymers and hydrogels of the present invention can be used for the repair or restoration of cartilage, especially articular cartilage. The polymers comprise at least a monomer for binding water, a monomer for imparting mechanical properties and a monomer for binding to an extracellular protein. The hydrogels comprise a polymer comprising at least a monomer for binding water and a monomer for binding to an extracellular protein. Crosslinking polymers by binding of said extra-cellular matrix protein forms hydrogels.