Patents by Inventor Aliasger K. Salem

Aliasger K. Salem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS COMPRISING MOLECULES FOR CYSTIC FIBROSIS TREATMENT
    Publication number: 20240100183
    Abstract: Composition and methods to prevent, inhibit or treat one or more symptoms of cystic fibrosis are provided.
    Type: Application
    Filed: December 10, 2021
    Publication date: March 28, 2024
    Inventors: Aliasger K. Salem, David A. Stoltz, Michael J. Welsh, Sarah Ernst, Youssef W. Naguib, David S. NAkhla, Aml I. Mekkawy, Nikesh Gupta
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20240082238
    Abstract: The invention provides methods, compositions, and kits that are useful for treating cancer (e.g., endometrial cancer).
    Type: Application
    Filed: August 18, 2022
    Publication date: March 14, 2024
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Aliasger K. Salem, Kareem Ebeid, Youssef Wahib Naguib Ibrahim, Sanjib Saha, Emad I. Wafa, Suhaila Alhaj-Suliman
  • Poly(diaminosulfide) particle-based vaccine
    Patent number: 11904006
    Abstract: A composition comprising particles formed of poly(diaminosulfide) and one or more leptospiral antigens, and methods of making and using the composition, are provided.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: February 20, 2024
    Assignees: University of Iowa Research Foundation, The United States of America, As Represented by The Secretary of Agriculture
    Inventors: Aliasger K. Salem, Emad I. Wafa, Sean M. Geary, Ned B. Bowden, Jennifer H. Wilson-Welder, David P. Alt
  • GPER PROTEOLYTIC TARGETING CHIMERAS
    Publication number: 20230312639
    Abstract: A molecule comprising a G-protein coupled estrogen receptor (GPER) ligand coupled to a linker coupled to an E3 ubiquitin ligase ligand and methods of using the molecule are provided. In one embodiment, the GPER ligand is estradiol and the E3 ubiquitin ligase ligand is (S,R,S)- AHPC.
    Type: Application
    Filed: April 23, 2021
    Publication date: October 5, 2023
    Inventors: Aliasger K. Salem, Edward J. Filardo, Anh S. Lu, Milad Rouhimoghadam
  • CATIONIC NANOPARTICLE ADJUVANTS
    Publication number: 20230293678
    Abstract: A cationic nanoparticle formed of a biodegradable or biocompatible synthetic polymer and a dendrimer having a diameter of about 125 nm to 1000 nm, and methods of using the nanoparticle, e.g., for delivery of an immunogen, are provided.
    Type: Application
    Filed: August 20, 2021
    Publication date: September 21, 2023
    Inventors: Aliasger K. Salem, Sean M. Geary, Kareem Ebeid, Emad I. Wafa, Rasheid Smith
  • FORMULATION FOR DELIVERY OF LUBRICIN GENE
    Publication number: 20230001017
    Abstract: Compositions comprising nanoparticles, nanoplexes or virus comprising isolated nucleic acid comprising nucleic acid encoding a mammalian, and methods of using the compositions, are provided.
    Type: Application
    Filed: October 28, 2020
    Publication date: January 5, 2023
    Inventors: Aliasger K. Salem, James A. Martin, Leela Raghava Jaidev Chakka, Juliana c. Quarterman, Hongjun Zheng, Dong Rim Seol
  • JNK INHIBITORS AS ANTICANCER AGENTS
    Publication number: 20220411398
    Abstract: Compounds that inhibit JNK, e.g., JNK2 and/or JNK3, such as fused thiophenes, and methods of making and using the compounds are provided.
    Type: Application
    Filed: June 24, 2020
    Publication date: December 29, 2022
    Inventors: Aliasger K. Salem, Somaya Ali Mohammed Elsaid Abdelrahman
  • METHODS TO PREVENT, INHIBIT OR TREAT INTERVERTEBRAL DISC DEGENERATION
    Publication number: 20220265700
    Abstract: A method to prevent, inhibit or treat intervertebral disc disease in a mammal and compositions useful in that regard are provided.
    Type: Application
    Filed: January 20, 2022
    Publication date: August 25, 2022
    Inventors: Dong Rim Seol, James A. Martin, Tae-Hong Lim, Mitchell C. Coleman, Aliasger K. Salem, Ino Song
  • COMPOSITION COMPRISING AN ANTI-OXIDANT TO PRESERVE CORNEAL TISSUE
    Publication number: 20220249399
    Abstract: A composition comprising an amount of an anti-oxidant comprising one or more of ubiquinol, MitoQ, vitamin E, vitamin C, ascorbate-2-phosphate, idebenone, pyrroloquinoline quinone (PQQ), N-acetyl-L-cysteine (NAC), palmitate, reduced glutathione, or a C14-C18 saturated fatty acid effective to preserve, e.g., corneal tissue, and methods of using the composition, are provided.
    Type: Application
    Filed: March 4, 2020
    Publication date: August 11, 2022
    Inventors: Aliasger K. Salem, Youssef Wahib Naguib lbrahim, Somaya Ali Mohammed Elsaid Abdelrahman, Jessica M. Skeie, Benjamin T. Aldrich, Gregory Schmidt, Cynthia R. Reed, Mark A. Greiner, Darryl Y. Nishimura, Sanjib Saha
  • NANOPARTICLES COMPRISING QUINONE W METHIDES AND COMPOSITIONS FOR USE
    Publication number: 20220241214
    Abstract: A nanoparticle comprising one or more quinonemethide triterpenoids or one or more inhibitors of metadherin, and methods of using the nanoparticles, are provided.
    Type: Application
    Filed: June 19, 2020
    Publication date: August 4, 2022
    Inventors: Aliasger K. Salem, Kimberly Leslie, Xiangbing Meng, Jianling Bi, Kareem Ebeid, Sudartip Areecheewakul
  • SYNTHETICALLY LETHAL NANOPARTICLES FOR TREATMENT OF CANCERS
    Publication number: 20220110882
    Abstract: Disclosed are nanoparticle compositions and methods for treating cancer in a subject in need thereof. The nanoparticle compositions and methods may be utilized to treat cancers in a subject that are characterized by susceptibility to synthetic lethality via administering a combination of agents that induce synthetic lethality.
    Type: Application
    Filed: November 17, 2021
    Publication date: April 14, 2022
    Inventors: Aliasger K. Salem, Kristina Thiel, Kimberly Leslie, Kareem Ebeid
  • Preloaded DMEK Holder
    Publication number: 20210401562
    Abstract: A Descemet Membrane Endothelial Keratoplasty (DMEK) holder for placement within a vial for supporting a corneal tissue inserter is provided. The DMEK holder includes a top and an opposite bottom, at least one support member extending between the top and the bottom, with a bottom portion of the at least one support member sized and shaped to fit against a bottom inner surface of the vial to thereby support the corneal tissue inserter within the vial, and a first annular member having an opening sized and shaped such that a bottom end of the corneal tissue inserter is insertable through the opening and the first annular member separates the corneal tissue inserter from an inner surface of the vial and positions the corneal tissue inserter within the vial away from inner surfaces of the vial to thereby improve retrieval of the corneal tissue inserter by a surgeon.
    Type: Application
    Filed: June 28, 2021
    Publication date: December 30, 2021
    Applicant: University of Iowa Research Foundation
    Inventors: Syed M. A. Muqsit Hashmi, Leela Raghava Jaidev Chakka, Aliasger K. Salem
  • POLY(DIAMINOSULFIDE) PARTICLE-BASED VACCINE
    Publication number: 20210379172
    Abstract: A composition comprising particles formed of poly(diamidosulfide) and one or more leptospiral antigens, and methods of making and using the composition, are provided.
    Type: Application
    Filed: December 11, 2020
    Publication date: December 9, 2021
    Inventors: Aliasger K. Salem, Emad I. Wafa, Sean M. Geary, Ned B. Bowden, Jennifer H. Wilson-Welder, David P. Alt
  • MEK1/2 INHIBITOR-LOADED MICROPARTICLE FORMULATION
    Publication number: 20210361578
    Abstract: A composition comprising microparticles or liposomes comprising one or more MEK1/2 inhibitors, and methods of using the composition, are provided.
    Type: Application
    Filed: April 2, 2021
    Publication date: November 25, 2021
    Inventors: Aliasger K. Salem, Robert Felder, Youssef Wahib Naguib Ibrahim
  • IMPLANTS TO INDUCE BONE REGENERATION AND USES THEREOF
    Publication number: 20210308326
    Abstract: Disclosed herein are compositions to facilitate bone growth, formation, and/or repair. Methods of using and making the compositions are also disclosed.
    Type: Application
    Filed: July 18, 2019
    Publication date: October 7, 2021
    Inventors: Aliasger K. Salem, Behnoush Khorsand Sourkohi, John E. Femino, Douglas Fredericks
  • SYNTHETICALLY LETHAL NANOPARTICLES FOR TREATMENT OF CANCERS
    Publication number: 20200390717
    Abstract: Disclosed are nanoparticle compositions and methods for treating cancer in a subject in need thereof. The nanoparticle compositions and methods may be utilized to treat cancers in a subject that are characterized by susceptibility to synthetic lethality via administering a combination of agents that induce synthetic lethality.
    Type: Application
    Filed: November 20, 2018
    Publication date: December 17, 2020
    Inventors: Aliasger K. Salem, Kristina Thiel, Kimberly Leslie, Kareem Ebeid
  • RNA BASED BIOMATERIAL FOR TISSUE ENGINEERING APPLICATIONS
    Publication number: 20200222559
    Abstract: The present disclosure provides compositions and methods useful for tissue engineering including a composition having chemically modified RNA (cmRNA) encapsulated in or complexed with a non-viral delivery vehicle and a biocompatible, bioresorbable scaffold and methods of using the composition to regenerate, for example, bone tissue.
    Type: Application
    Filed: May 30, 2019
    Publication date: July 16, 2020
    Inventors: Satheesh Elangovan, Sheetal Reginald R. D'mello, Anh-Vu T. Do, Liu Hong, Behnoush Khorsand-Sourkohi, Aliasger K. Salem, Michael Kormann
  • Methods to prevent or treat periodontitis or peri-implantitis
    Patent number: 10669543
    Abstract: Compositions and methods to prevent, inhibit or treat aveolar or periodontal bone loss, enhance bone regeneration, prevent, inhibit or treat peri-implantitis or periodontitis, e.g., periodontitis or peri-implantitis associated with bone loss, or to prevent, inhibit or treat osteoarthritis are provided.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: June 2, 2020
    Assignee: University of Iowa Research Foundation
    Inventors: Liu Hong, Brad A. Amendt, Aliasger K. Salem, Satheesh Elangovan, Gustavo Avila Ortiz, Thad Sharp
  • RNA based biomaterial for tissue engineering applications
    Patent number: 10335498
    Abstract: The present disclosure provides compositions and methods useful for tissue engineering including a composition having chemically modified RNA (cmRNA) encapsulated in or complexed with a non-viral delivery vehicle and a biocompatible, bioresorbable scaffold and methods of using the composition to regenerate, for example, bone tissue.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: July 2, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Satheesh Elangovan, Sheetal Reginald R D'mello, Anh-Vu T Do, Liu Hong, Behnoush Khorsand-Sourkohi, Aliasger K Salem, Michael Kormann
  • Methods for treating tumors in situ including intratumor injection of cytotoxic particles and immune checkpoint blockade therapy
    Patent number: 10314854
    Abstract: Disclosed are compositions, kits, and methods for treating cancer in a subject in need thereof. The compositions, kits, and methods may be used to treat a tumor in a subject in situ. The compositions, kits, and methods comprise or utilize cytotoxic particles, immune checkpoint inhibitors, and/or T-cell stimulatory agents.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: June 11, 2019
    Assignee: University of Iowa Foundation
    Inventors: Aliasger K. Salem, Amani Makkouk, Vijaya B. Joshi, George Weiner