Patents by Inventor Alice Mui

Alice Mui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying allosteric modulators of ship polypeptides
    Patent number: 8956824
    Abstract: This invention provides a method for identifying allosteric modulators of a SHIP polypeptide, wherein said SHIP polypeptide is contacted with a test compound, and wherein said SHIP polypeptide comprises an allosteric site selected from the group consisting of a SHIP C2 domain and a SHIP PH domain.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: February 17, 2015
    Assignee: British Columbia Cancer Agency Branch
    Inventors: Alice Mui, Christopher Ong, Gerald Krystal, Raymond Andersen
  • Ship 1 modulators
    Patent number: 8765994
    Abstract: The present invention includes the use of pelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP 1 activity. This invention also provides novel terpene compounds capable of modulating SHIP 1 activity and methods of synthesis thereof.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: July 1, 2014
    Assignee: The University of British Columbia
    Inventors: Raymond Andersen, David E. Williams, Alice Mui, Christopher Ong, Gerald Krystal, Lu Yang
  • SHIP 1 MODULATORS
    Publication number: 20120129925
    Abstract: The present invention includes the use of pelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP 1 activity. This invention also provides novel terpene compounds capable of modulating SHIP 1 activity and methods of synthesis thereof.
    Type: Application
    Filed: August 19, 2011
    Publication date: May 24, 2012
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Raymond Andersen, David E. Williams, Alice Mui, Christopher Ong, Gerald Krystal, Lu Yang
  • SHIP 1 MODULATOR COMPOUNDS
    Publication number: 20110263539
    Abstract: The present invention provides the use of pelorol analogs of Formula, (I) and pharmaceutical compositions thereof as modulators of SHIP 1 activity. A compound or a pharmaceutical composition of the present invention may be used for the treatment or prophylaxis of an inflammatory, neoplastic, hematopoetic or immune disorder or condition in addition to other disorders and conditions.
    Type: Application
    Filed: June 21, 2007
    Publication date: October 27, 2011
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Raymond Andersen, Matthew Nodwell, Alice Mui
  • Methods of Diagnosing Rejection of a Kidney Allograft Using Genomic or Proteomic Expression Profiling
    Publication number: 20110189680
    Abstract: A method of determining the acute allograft rejection status of a subject, the method comprising the steps of: determining the nucleic acid expression profile of one or more than one nucleic acid markers, or one or more than one proteomic markers in a biological sample from the subject; comparing the expression profile of the one or more than one nucleic acid markers to a control profile; and determining whether the expression level of the one or more than one nucleic acid markers is increased relative to the control profile, wherein the increase of the one or more than one nucleic acid markers is indicative of the acute rejection status of the subject.
    Type: Application
    Filed: May 29, 2009
    Publication date: August 4, 2011
    Applicant: The University of British Columbia
    Inventors: Paul Keown, Andreas Scherer, Oliver Gunther, Robert Balshaw, Raymond Ng, Alice Mui, Robert McMaster, Bruce McManus, Gabriela Cohen Freue, Anna Meredith
  • METHODS OF DIAGNOSING ACUTE CARDIAC ALLOGRAFT REJECTION
    Publication number: 20110171645
    Abstract: The present invention relates to methods of diagnosing acute rejection of a cardiac allograft using genomic expression profiling, proteomic expression profiling, metabolite profiling, or alloreactive T-cell genomic expression profiling,
    Type: Application
    Filed: April 9, 2009
    Publication date: July 14, 2011
    Applicant: The University of British Columbia
    Inventors: Bruce McManus, Zsuzsanna Hollander, Alice Mui, Robert Balshaw, Robert Mcmaster, Paul Keown, Gabriela Cohen Freue, Pooran Qasimi, Raymond Ng, David Lin, David Wishart, Axel Bergman
  • SHIP 1 MODULATOR PRODRUGS
    Publication number: 20100323990
    Abstract: The present invention provides the use of prodrugs of pelorol and homopelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP1 activity. A compound or a pharmaceutical composition of the present invention may be used for the treatment or prophylaxis of an inflammatory, neoplastic, hematopoetic or immune disorder or condition in addition to other disorders and conditions.
    Type: Application
    Filed: June 21, 2007
    Publication date: December 23, 2010
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Raymond Andersen, Matthew Nodwell, Alice Mui
  • Allosteric Modulation Of Ship Polypeptides And Uses Thereof
    Publication number: 20100311094
    Abstract: This invention provides a method for identifying allosteric modulators of a SHIP polypeptide, wherein said SHIP polypeptide is contacted with a test compound, and wherein said SHIP polypeptide comprises an allosteric site selected from the group consisting of a SHIP C2 domain and a SHIP PH domain.
    Type: Application
    Filed: June 4, 2009
    Publication date: December 9, 2010
    Inventors: Alice Mui, Christopher Ong, Gerald Krystal, Raymond Andersen
  • COMPOSITIONS AND METHODS FOR TREATING MYELOSUPPRESSION
    Publication number: 20100099737
    Abstract: The invention provides, in part, compositions and methods for protecting a hemopoietic cell, or for treating myelosuppression, in a subject in need thereof, by administering an effective amount of an inhibitor of a SH2-containing inositol-5?-phosphatase.
    Type: Application
    Filed: August 24, 2007
    Publication date: April 22, 2010
    Inventors: Gerald Krystal, Christopher Ong, Alice Mui
  • Ship 1 Modulators
    Publication number: 20080090909
    Abstract: The present invention includes the use of pelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP 1 activity. This invention also provides novel terpene compounds capable of modulating SHIP 1 activity and methods of synthesis thereof.
    Type: Application
    Filed: October 11, 2007
    Publication date: April 17, 2008
    Inventors: Raymond Andersen, David Williams, Alice Mui, Christopher Ong, Gerald Krystal, Lu Yang
  • SHIP 1 modulators
    Publication number: 20040266865
    Abstract: The present invention includes the use of pelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP 1 activity. This invention also provides novel terpene compounds capable of modulating SHIP 1 activity and methods of synthesis thereof.
    Type: Application
    Filed: April 16, 2004
    Publication date: December 30, 2004
    Inventors: Raymond Andersen, David E. Williams, Alice Mui, Christopher Ong, Gerald Krystal