Patents by Inventor Alim LADHA

Alim LADHA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENE EDITING COMPONENTS, SYSTEMS, AND METHODS OF USE
    Publication number: 20240141382
    Abstract: The present disclosure provides methods and compositions comprising novel Cas TypeV programmable nucleases and lipid nanoparticles capable of delivering the Cas TypeV programmable nucleases and genome editing systems comprising same. For therapeutic applications, as well as plants and industrial biotechnology.
    Type: Application
    Filed: October 5, 2023
    Publication date: May 2, 2024
    Inventors: Giedrius Gasiunas, Alim Ladha, Vladimir Presnyak, Muthusamy Jayaraman
  • NUCLEASE-GUIDED NON-LTR RETROTRANSPOSONS AND USES THEREOF
    Publication number: 20240132916
    Abstract: Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of CRISPR systems and non-LTR retrotransposon elements.
    Type: Application
    Filed: February 9, 2022
    Publication date: April 25, 2024
    Inventors: Feng Zhang, Michael Segel, Alim Ladha, Michelle Walsh, Christopher Frangieh
  • GENE EDITING COMPONENTS, SYSTEMS, AND METHODS OF USE
    Publication number: 20240084274
    Abstract: The present disclosure provides methods and compositions comprising novel Cas TypeV programmable nucleases and lipid nanoparticles capable of delivering the Cas TypeV programmable nucleases and genome editing systems comprising same. For therapeutic applications, as well as plants and industrial biotechnology.
    Type: Application
    Filed: April 7, 2023
    Publication date: March 14, 2024
    Applicant: ReNAgade Therapeutics Management Inc.
    Inventors: Giedrius Gasiunas, Alim Ladha, Vladimir Presnyak, Muthusamy Jayaraman
  • T-DNA MEDIATED GENETIC MODIFICATION
    Publication number: 20240043828
    Abstract: Described in several embodiments herein are compositions, systems, and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Described in several embodiments are nucleic acid targeting systems that include components of CRISPR systems, VirD polypeptide(s), and DNA polymerase(s).
    Type: Application
    Filed: October 5, 2021
    Publication date: February 8, 2024
    Inventors: Feng Zhang, Alim Ladha
  • Engineered retrons and methods of use
    Patent number: 11866728
    Abstract: Disclosed are engineered retrons and methods of use such as to modify the genome of a host (e.g., mammalian) cell by delivering the engineered retron or the encoded ncRNA in vitro or in vivo to the host (e.g., mammalian) cell.
    Type: Grant
    Filed: December 22, 2022
    Date of Patent: January 9, 2024
    Assignee: RENAGADE THERAPEUTICS MANAGEMENT INC.
    Inventors: Alim Ladha, Vladimir Presnyak, Inna Shcherbakova, Brian Goodman, Mario Rodriguez Mestre, Devin Scott Quinlan, Muthusamy Jayaraman, Stephen Scully
  • Rapid diagnostics
    Patent number: 11851702
    Abstract: Systems and methods for rapid diagnostics related to the use of isothermal amplification reagents for detection of microbial species, including coronavirus, and methods of use, are provided.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: December 26, 2023
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Jonathan Gootenberg, Omar Abudayyeh, Julia Joung, Alim Ladha, Han Altae-Tran, Guilhem Faure
  • COMPOSITIONS AND METHODS FOR ENHANCED LENTIVIRAL PRODUCTION
    Publication number: 20230365989
    Abstract: Described herein are engineered retroviral delivery vesicle generation compositions, systems, and methods to deliver a cargo to a cell. The engineered compositions, systems, and method include one or more polynucleotides encoding one or more elements for forming a delivery vesicle and optionally one or more cargos.
    Type: Application
    Filed: March 19, 2021
    Publication date: November 16, 2023
    Inventors: Feng Zhang, Alim Ladha
  • CRISPR-ASSOCIATED TRANSPOSASE SYSTEMS AND METHODS OF USE THEREOF
    Publication number: 20230265420
    Abstract: The present application provides systems, methods and compositions used for targeted gene modification, targeted insertion, perturbation of gene transcripts, nucleic acid editing. Novel nucleic acid targeting systems comprise components of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements.
    Type: Application
    Filed: June 18, 2021
    Publication date: August 24, 2023
    Inventors: Feng Zhang, Jonathan Strecker, Alim Ladha, Guilhem Faure
  • ENGINEERED RETRONS AND METHODS OF USE
    Publication number: 20230235365
    Abstract: Disclosed are engineered retrons and methods of use such as to modify the genome of a host (e.g., mammalian) cell by delivering the engineered retron or the encoded ncRNA in vitro or in vivo to the host (e.g., mammalian) cell.
    Type: Application
    Filed: December 22, 2022
    Publication date: July 27, 2023
    Applicant: ReNAgade Therapeutics Management Inc.
    Inventors: Alim Ladha, Vladimir Presnyak, Brian Goodman, Mario Rodriguez Mestre, Devin Scott Quinlan, Muthusamy Jayaraman, Stephen Scully
  • Type V CRISPR-Cas systems and use thereof
    Patent number: 11639523
    Abstract: Engineered or non-naturally occurring systems and compositions comprising a novel Cas12b and a guide molecule. Also provided include methods of use the systems and compositions, including in treating and diagnosing diseases.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: May 2, 2023
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Jonathan Gootenberg, Omar Abudayyeh, Julia Joung, Alim Ladha, Han Altae-Tran, Guilhem Faure
  • FIELD DEPLOYABLE CRISPR-CAS DIAGNOSTICS AND METHODS OF USE THEREOF
    Publication number: 20230127948
    Abstract: Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided.
    Type: Application
    Filed: February 12, 2021
    Publication date: April 27, 2023
    Inventors: Jonathan Gootenberg, Omar Abudayyeh, Julia Joung, Alim Ladha, Han Altae-Tran, Guilhem Faure, Feng Zhang
  • CRISPR-ASSOCIATED TRANSPOSASE SYSTEMS AND METHODS OF USE THEREOF
    Publication number: 20230056577
    Abstract: The present application provides systems, methods and compositions used for targeted gene modification, targeted insertion, perturbation of gene transcripts, nucleic acid editing. Novel nucleic acid targeting systems comprise components of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements.
    Type: Application
    Filed: May 12, 2022
    Publication date: February 23, 2023
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Jonathan Strecker, Alim Ladha
  • RETROTRANSPOSONS AND USE THEREOF
    Publication number: 20230040216
    Abstract: Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of CRISPR systems and non-LTR retrotransposon elements.
    Type: Application
    Filed: November 18, 2020
    Publication date: February 9, 2023
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Michael Segel, Alim Ladha
  • CRISPR EFFECTOR SYSTEM BASED CORONAVIRUS DIAGNOSTICS
    Publication number: 20220325334
    Abstract: Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided.
    Type: Application
    Filed: April 27, 2022
    Publication date: October 13, 2022
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Jonathan Gootenberg, Omar Abudayyeh, Julia Joung, Alim Ladha, Han Altae-Tran, Guilhem Faure
  • Processes for the production of cannabinoids from a carbon source precursor
    Patent number: 11459592
    Abstract: A method is provided for biosynthetic production of cannabinoids in microorganisms from a carbon source precursor. This method describes the genetic modifications needed to engineer microorganisms to produce cannabinoids as well as a method for identifying and quantifying cannabinoids from fermentation broth. A system is also provided for tuning the method to produce different cannabinoids of interest by systematically modulating the enzymes encoded by the genetic modifications introduced in the microorganism.
    Type: Grant
    Filed: October 12, 2020
    Date of Patent: October 4, 2022
    Assignee: SYNTIVA THERAPEUTICS, INC.
    Inventors: Adam Davidovich, Brian Chan, Neil Gupta, Alim Ladha
  • Crispr effector system based coronavirus diagnostics
    Patent number: 11453907
    Abstract: Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: September 27, 2022
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Jonathan Gootenberg, Omar Abudayyeh, Julia Joung, Alim Ladha, Han Altae-Tran, Guilhem Faure
  • CRISPR-associated transposase systems and methods of use thereof
    Patent number: 11384344
    Abstract: The present application provides systems, methods and compositions used for targeted gene modification, targeted insertion, perturbation of gene transcripts, nucleic acid editing. Novel nucleic acid targeting systems comprise components of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: July 12, 2022
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Feng Zhang, Jonathan Strecker, Alim Ladha
  • NOVEL TYPE V CRISPR-CAS SYSTEMS AND USE THEREOF
    Publication number: 20210292721
    Abstract: Engineered or non-naturally occurring systems and compositions comprising a novel Cas12b and a guide molecule. Also provided include methods of use the systems and compositions, including in treating and diagnosing diseases.
    Type: Application
    Filed: June 5, 2020
    Publication date: September 23, 2021
    Inventors: Feng Zhang, Jonathan Gootenberg, Omar Abudayyeh, Julia Joung, Alim Ladha, Han Altae-Tran, Guilhem Faure
  • CRISPR EFFECTOR SYSTEM BASED CORONAVIRUS DIAGNOSTICS
    Publication number: 20210292824
    Abstract: Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided.
    Type: Application
    Filed: June 5, 2020
    Publication date: September 23, 2021
    Inventors: Feng Zhang, Jonathan Gootenberg, Omar Abudayyeh, Julia Joung, Alim Ladha, Han Altae-Tran, Guilhem Faure
  • RAPID DIAGNOSTICS
    Publication number: 20210292823
    Abstract: Systems and methods for rapid diagnostics related to the use of isothermal amplification reagents for detection of microbial species, including coronavirus, and methods of use, are provided.
    Type: Application
    Filed: June 5, 2020
    Publication date: September 23, 2021
    Inventors: Feng Zhang, Jonathan Gootenberg, Omar Abudayyeh, Julia Joung, Alim Ladha, Han Altae-Tran, Guilhem Faure