Patents by Inventor Alina Seralena Menendez

Alina Seralena Menendez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Streptokinase mutants
    Patent number: 6413759
    Abstract: The present invention is related to the field of biotechnology and genetic engineering techniques, particularly to a method for obtaining mutants obtain from streptokinase, to the molecules obtained from this method, as well as the expression vectors and microorganisms for recombinant obtaining. The object of the present invention is to achieve streptokinase mutants from modifications of skc-2 gene coding for streptokinase SKC-2 (Heberkinase®), such that the obtained mutants conserve their capacity for plasminogen activator complex formation having reduced antigenicity, that could constitute preferred alternatives to native streptokinase for thrombolytic therapy. The molecules obtained from present invention can be used in the treatment of disorders as myocardial infarct, pulmonary thromboembolism, surgical complications and other cases of thrombosis.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: July 2, 2002
    Assignee: Centro de Ingenieria Genetica y Biotecnologia
    Inventors: Isis del Carmen Torrens Madrazo, Jose de la Fuente Garcia, Ariana Garcia Ojalvo, Alina Seralena Menendez, Elder Pupo Escalona, Julio Raul Fernandez Masso, Martha de Jesus Gonzalez Griego
  • Streptokinase mutants
    Patent number: 6309873
    Abstract: The present invention is related to the field of biotechnology and genetic engineering techniques, particularly to a method for obtaining mutants obtain from streptokinase, to the molecules obtained from this method, as well as the expression vectors and microorganisms for recombinant obtaining. The object of the present invention is to achieve streptokinase mutants from modifications of skc-2 gene coding for streptokinase SKC-2 (Heberkinase®), such that the obtained mutants conserve their capacity for plasminogen activator complex formation having reduced antigenicity, that could constitute preferred alternatives to native streptokinase for thrombolytic therapy. The molecules obtained from present invention can be used in the treatment of disorders as myocardial infarct, pulmonary thromboembolism, surgical complications and other cases of thrombosis.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: October 30, 2001
    Assignee: Centro de Ingenieria Genetica y Biotechnologia
    Inventors: Isis del Carmen Torrens Madrazo, Jose de la Fuente Garcia, Ariana Garcia Ojalvo, Alina Seralena Menendez, Elder Pupo Escalona, Julio Raul Fernandez Masso, Martha de Jesus Gonzalez Griego