Patents by Inventor Alistair Stewart Taylor

Alistair Stewart Taylor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8052746
    Abstract: The present invention relates to a balloon expandable stent mounted on a balloon catheter, the entire assembly being overcoated with a coherent polymer coating, which is preferably substantially continuous over the circumference and, more preferably, axial length of the stem on the balloon. The polymer coating improves retention of the stent on the balloon during delivery and does not adversely effect the deployment characteristics, nor the balloon failure characteristics. The product is made by mounting the stent on the balloon and coating the assembly with a liquid coating composition containing a suitable polymer followed by curing of the coating. The polymer is biocompatible and preferably crosslinkable in the coating composition, and crosslinked in the final product. A suitable polymer is formed from monomers including a zwitterionic, preferably a phosphoryl choline, group, and monomers including a trialkoxysilyl group.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: November 8, 2011
    Assignee: Biocompatibles Limited
    Inventors: Peter William Stratford, Alistair Stewart Taylor, Vincent James O'Byrne, John Tom Clarke, Denis Dominic Healy
  • Patent number: 7794775
    Abstract: The present invention relate to a balloon expandable stent mounted on a balloon catheter, the entire assembly being overcoated with a coherent polymer coating, which is preferably substantially continuous over the circumference and, more preferably, axial length of the stent on the balloon. The polymer coating improves retention of the stent on the balloon during delivery and does not adversely effect the deployment characteristics, nor the balloon failure characteristics. The product is made by mounting the stent on the balloon and coating the assembly with a liquid coating composition containing a suitable polymer followed by curing of the coating. The polymer is biocompatible and preferably crosslinkable in the coating composition, and crosslinked in the final product. A suitable polymer is formed from monomers including a zwitterionic, preferably a phosphoryl choline, group, and monomers including a trialkoxysilyl group.
    Type: Grant
    Filed: November 16, 2005
    Date of Patent: September 14, 2010
    Assignee: Biocompatibles Limited
    Inventors: Peter William Stratford, Alistair Stewart Taylor, Vincent James O'Byrne, John Tom Clarke, Denis Dominic Healy
  • Patent number: 7754272
    Abstract: An implant having a coating comprising a polymer matrix is swollen in a pharmaceutical solution whereby pharmaceutically active compound is imbibed into the polymer matrix. When the product is implanted, release of the pharmaceutically active compound from the coating takes place. The polymer is preferably formed from ethylenically unsaturated monomers including a zwitterionic monomer, most preferably 2-methacryloyloxyethyl-2?-trimethylammoniumethyl-phosphate inner salt. The monomers from which the polymer is formed may further include surface binding monomers, such as hydrophobic group containing monomers, and crosslinkable monomers, the content of which may be used to control the swellability. Preferably the implant is a stent and the coating of polymer on the exterior wall surface is thicker than the coating of polymer on the interior surface. Release of the drug may be controlled by selection of comonomers. The implant is suitably a stent for use in the cardiovascular system.
    Type: Grant
    Filed: May 11, 2004
    Date of Patent: July 13, 2010
    Assignee: Biocompatibles IK Limited
    Inventors: Lee Rowan, Peter William Stratford, Alistair Stewart Taylor, Terrence Albert Vick
  • Patent number: 7306625
    Abstract: The present invention relates to a balloon expandable stent mounted on a balloon catheter, the entire assembly being overcoated with a coherent polymer coating, which is preferably substantially continuous over the circumference and, more preferably, axial length of the stent on the balloon. The polymer coating improves retention of the stent on the balloon during delivery and does not adversely effect the deployment characteristics, nor the balloon failure characteristics. The product is made by mounting the stent on the balloon and coating the assembly with a liquid coating composition containing a suitable polymer followed by curing of the coating. The polymer is biocompatible and preferably crosslinkable in the coating composition, and crosslinked in the final product. A suitable polymer is formed from monomers including a zwitterionic, preferably a phosphoryl choline, group, and monomers including a trialkoxysilyl group.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: December 11, 2007
    Assignee: Abbott Laboratories
    Inventors: Peter William Stratford, Alistair Stewart Taylor, Vincent James O'Byrne, John Tom Clarke, Denis Dominic Healy
  • Patent number: 6872225
    Abstract: An implant having a coating comprising a polymer matrix is swollen in a pharmaceutical solution whereby pharmaceutically active compound is imbibed into the polymer matrix. When the product is implanted, release of the pharmaceutically active compound from the coating takes place. The polymer is preferably formed from ethylenically unsaturated monomers including a zwitterionic monomer, most preferably 2-methacryloyloxyethyl-2?-trimethylammoniumethylphosphate inner salt. The monomers from which the polymer is formed may further include surface binding monomers, such as hydrophobic group containing monomers, and crosslinkable monomers, the content of which may be used to control the swellability. Preferably the implant is a stent and the coating of polymer on the exterior wall surface is thicker than the coating of polymer on the interior surface. Release of the drug may be controlled by selection of comonomers. The implant is suitably a stent for use in the cardiovascular system.
    Type: Grant
    Filed: May 30, 2000
    Date of Patent: March 29, 2005
    Assignee: Biocompatibles UK Limited
    Inventors: Lee Rowan, Peter William Stratford, Alistair Stewart Taylor, Terrence Albert Vick
  • Publication number: 20040208985
    Abstract: An implant having a coating comprising a polymer matrix is swollen in a pharmaceutical solution whereby pharmaceutically active compound is imbibed into the polymer matrix. When the product is implanted, release of the pharmaceutically active compound from the coating takes place. The polymer is preferably formed from ethylenically unsaturated monomers including a zwitterionic monomer, most preferably 2-methacryloyloxyethyl-2′-trimethylammoniumethylphosphate inner salt. The monomers from which the polymer is formed may further include surface binding monomers, such as hydrophobic group containing monomers, and crosslinkable monomers, the content of which may be used to control the swellability. Preferably the implant is a stent and the coating of polymer on the exterior wall surface is thicker than the coating of polymer on the interior surface. Release of the drug may be controlled by selection of comonomers. The implant is suitably a stent for use in the cardiovascular system.
    Type: Application
    Filed: May 11, 2004
    Publication date: October 21, 2004
    Applicant: BIOCOMPATIBLES UK LIMITED
    Inventors: Lee Rowan, Peter William Stratford, Alistair Stewart Taylor, Terrence Albert Vick
  • Patent number: 6497916
    Abstract: An apparatus for coating tubular members, such as stents comprises a liquid reservoir and a stent support member for supporting, in use, a tubular member. Support member dipping means places the support member in the liquid reservoir in use and draws the support member therefrom. Pressure differential generating means generates a pressure differential. The stent support member is arranged to provide a central passageway through a stent placed thereon, the central passageway having a plurality of perforations formed therein, and the pressure differential generating means is arranged to generate, in use, a pressure differential between the passageway and the tubular member.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: December 24, 2002
    Assignee: Biocompatibles Limited
    Inventors: Alistair Stewart Taylor, Lee Alan Tollhurst, Donal Thomas Hempensall
  • Patent number: 6214115
    Abstract: The invention provides an apparatus for coating tubular members, such as stents, and also provides a method for coating tubular members. The invention improves manufacturing efficiencies of existing manual-dipping technology for stents and also addresses manufacturing problems from stents having plural surface apertures associated with the presence of excess liquid, inconsistent drying of the liquid and blockage.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: April 10, 2001
    Assignee: Biocompatibles Limited
    Inventors: Alistair Stewart Taylor, Lee Alan Tollhurst, Donal Thomas Hempensall
  • Patent number: 6083257
    Abstract: A braided stent (1) for transluminal implantation in body lumens is self-expanding and has a radial expanded configuration in which the angle .alpha. between filaments is acute. Some or all of filaments (6,7) are welded together in pairs at each end (4,5) of the stent to provide beads (8), thereby strengthening the stent and assisting its deployment from a delivery device. The stent is preferably completely coated using a biocompatible polymeric coating, said polymer preferably having pendant phosphoryl choline groups. A method of making the stent by braiding and welding is described as well as a delivery device for deploying the device.
    Type: Grant
    Filed: April 28, 1998
    Date of Patent: July 4, 2000
    Assignee: Biocompatibles Limited
    Inventors: Alistair Stewart Taylor, Peter William Stratford, Yiannakis Petrou Yianni, Matthew John Woodroffe
  • Patent number: 5851430
    Abstract: An HIPR emulsion of bitumen in water is prepared by a method which comprises directly mixing 70 to 98% by volume of bitumen having a viscosity in the range 200 to 500,000 mPa.s at the mixing temperature with 30 to 2% by volume of an aqueous solution of an emulsifying surfactant, percentages being expressed as percentages by volume of the total mixture. Mixing is effected under low shear conditions in the range 10 to 1,000 reciprocal seconds in such manner that an emulsion is formed comprising highly distorted bitumen droplets having mean droplet diameters in the range 2 to 50 micron separated by thin films of water.The emulsions can be cut back to provide stable emulsions of lower bitumen content which are useful in roadmaking and the formation of protective coatings.
    Type: Grant
    Filed: April 18, 1997
    Date of Patent: December 22, 1998
    Assignee: Intevep, S.A.
    Inventors: Maria Luisa Chirinos, Alistair Stewart Taylor, Spencer Edwin Taylor
  • Patent number: 5670087
    Abstract: An HIPR emulsion of bitumen in water is prepared by a method which comprises directly mixing 70 to 98% by volume of bitumen having a viscosity in the range 200 to 500,000 mPa.s at the mixing temperature with 30 to 2% by volume of an aqueous solution of an emulsifying surfactant, percentages being expressed as percentages by volume of the total mixture. Mixing is effected under low shear conditions in the range 10 to 1,000 reciprocal seconds in such manner that an emulsion is formed comprising highly distorted bitumen droplets having mean droplet diameters in the range 2 to 50 micron separated by thin films of water.The emulsions can be cut back to provide stable emulsions of lower bitumen content which are useful in road-making and the formation of protective coatings.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 23, 1997
    Assignee: Intevep, S.A.
    Inventors: Maria Luisa Chirinos, Alistair Stewart Taylor, Spencer Edwin Taylor
  • Patent number: 5641433
    Abstract: An HIPR (high internal phase ratio) emulsion of oil in water is prepared by directly mixing 70 to 98% by volume of a viscous oil having a viscosity in the range 200 to 250,000 mPa.s at the mixing temperature with 30 to 2% by volume of an aqueous solution of an emulsifying surfactant or an alkali, percentages being expressed as percentages by volume of the total mixture. Mixing is effected under low shear conditions in the range 10 to 1,000 reciprocal seconds in such manner that an emulsion is formed comprising highly distorted oil droplets having mean droplet diameters in the range 2 to 50 micron separated by thin interfacial films. The emulsions are much less viscous than the oils from which they are prepared and may, optionally after dilution, be pumped through a pipeline.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 24, 1997
    Assignee: Intevep, S.A.
    Inventors: Maria Luisa Chirinos, Alistair Stewart Taylor, Spencer Edwin Taylor
  • Patent number: RE40816
    Abstract: A braided stent (1) for transluminal implantation in body lumens is self-expanding and has a radial expanded configuration in which the angle ? between filaments is acute. Some or all of filaments (6,7) are welded together in pairs at each end (4,5) of the stent to provide beads (8), thereby strengthening the stent and assisting its deployment from a delivery device. The stent is preferably completely coated using a biocompatible polymeric coating, said polymer preferably having pendant phosphoryl choline groups. A method of making the stent by braiding and welding is described as well as a delivery device for deploying the device. The present invention provides a biocompatible crosslinked coating and a crosslinkable coating polymer composition for forming such a coating.
    Type: Grant
    Filed: November 1, 1996
    Date of Patent: June 30, 2009
    Assignee: Biocompatibles UK Limited
    Inventors: Alistair Stewart Taylor, Peter William Stratford, Yiannakis Petrou Yianni, Matthew John Woodroffe, Lee Rowan