Abstract: Anti-Kv1.3 antibodies (mAbs), particularly mAbs that specifically bind to Kv1.3 with high affinity and/or inhibit Kv1.3 function, are disclosed. The amino acid sequences of the CDRs of the light chains and the heavy chains, as well as consensus sequences for these CDRs, of these anti-Kv1.3 mAbs are provided. Additionally, canonical structures for CDRs in the VH and VL regions of anti-Kv1.3 antibodies are provided. The disclosure also provides nucleic acid molecules encoding the anti-Kv1.3 mAbs, expression vectors, host cells, methods for making the anti-Kv1.3 mAbs, and methods for expressing the anti-Kv1.3 mAbs. Finally, methods of using the anti-Kv1.3 mAbs as therapeutics, such as for preventing or treating an autoimmune disorder, are disclosed.

Abstract: A method and system is provided for balancing work load for a plurality of computer processors in a multiple processor computer system. In such a system, there are a plurality of packets to be processed. First, a plurality of hash buckets are generated and each packet is assigned to a bucket by performing a predetermined hash function. The different hash buckets are then assigned to the processors based on the workload of all the processors. In connection with processing connections with a timer thread, a plurality of connections are processed with a plurality of timer threads. A plurality of hash buckets are provided, and each connection is mapped to one of the hash buckets. Further, each hash bucket is assigned to a processor timer thread based on a workload thereof.

Abstract: A method and system is provided for balancing work load for a plurality of computer processors in a multiple processor computer system. In such a system, there are a plurality of packets to be processed. First, a plurality of hash buckets are generated and each packet is assigned to a bucket by performing a predetermined hash function. The different hash buckets are then assigned to the processors based on the workload of all the processors. In connection with processing connections with a timer thread, a plurality of connections are processed with a plurality of timer threads. A plurality of hash buckets are provided, and each connection is mapped to one of the hash buckets. Further, each hash bucket is assigned to a processor timer thread based on a workload thereof.

Abstract: A method and system is provided for balancing work load for a plurality of computer processors in a multiple processor computer system. In such a system, there are a plurality of packets to be processed. First, a plurality of hash buckets are generated and each packet is assigned to a bucket by performing a predetermined hash function. The different hash buckets are then assigned to the processors based on the workload of all the processors. In connection with processing connections with a timer thread, a plurality of connections are processed with a plurality of timer threads. A plurality of hash buckets are provided, and each connection is mapped to one of the hash buckets. Further, each hash bucket is assigned to a processor timer thread based on a workload thereof.