Patents by Inventor Alla Darwish

Alla Darwish has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Residualizing linkers and uses thereof
    Patent number: 11793895
    Abstract: The present invention relates to conjugates including a residualizing linker, methods for their production, and uses thereof.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: October 24, 2023
    Inventors: John Fitzmaurice Valliant, Eric Steven Burak, Neil G. Cockburn, Alla Darwish, Joel A. Drewry, John R. Forbes, Meiduo Hu, Ryan W. Simms, Karin A. Stephenson, Tao Wu
  • STAT INIHIBITORY COMPOUNDS AND COMPOSITIONS
    Publication number: 20230265055
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5). Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as, for example, breast cancer, hematological cancer, and pancreatic cancer.
    Type: Application
    Filed: September 3, 2021
    Publication date: August 24, 2023
    Inventors: Roman FLECK, John PROUDFOOT, Jeff OMEARA, Patrick Thomas GUNNING, Ahmed Magdy ALI, David Alexander ROSA, Angel Sampedro PALERM, Alla DARWISH, Alford Antoine JOHN
  • STAT INHIBITORY COMPOUNDS AND COMPOSITIONS
    Publication number: 20230159445
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5). Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as, for example, breast cancer and pancreatic cancer.
    Type: Application
    Filed: March 5, 2021
    Publication date: May 25, 2023
    Inventors: Roman FLECK, John PROUDFOOT, Jeff OMEARA, Krishna Kumar GNANASEKARAN, Patrick Thomas GUNNING, Alford Antoine JOHN, Angel Sampedro PALERM, Alla DARWISH, Dziyana KRASKOUSKAYA, Ahmed Magdy Ahmed Mohamed ALI
  • HETEROCYCLE CONTAINING STAT INHIBITORS AND COMPOSITIONS
    Publication number: 20230150946
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5). Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as, for example, breast cancer and pancreatic cancer.
    Type: Application
    Filed: March 5, 2021
    Publication date: May 18, 2023
    Inventors: Roman FLECK, John PROUDFOOT, Krishna Kumar GNANASEKARAN, Patrick Thomas GUNNING, Alford Antoine JOHN, Angel Sampedro PALERM, Alla DARWISH, Dziyana KRASKOUSKAYA
  • ALPHA SUBSTITUTED STAT INHIBITORS AND COMPOSITIONS THEREOF
    Publication number: 20230137956
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5). Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as, for example, breast cancer and pancreatic cancer.
    Type: Application
    Filed: March 5, 2021
    Publication date: May 4, 2023
    Inventors: Roman FLECK, John PROUDFOOT, Jeff OMEARA, Patrick Thomas GUNNING, Angel Sampedro PALERM, Alla DARWISH, Dziyana KRASKOUSKAYA
  • IGF-1R MONOCLONAL ANTIBODIES AND USES THEREOF
    Publication number: 20230052140
    Abstract: The present invention relates to conjugates including a chelating moiety of a metal complex thereof and a therapeutic or targeting moiety, methods for their production, and uses thereof.
    Type: Application
    Filed: July 28, 2022
    Publication date: February 16, 2023
    Inventors: Eric Steven Burak, John Richard Forbes, Matthew David Burr Moran, Ryan Wayne Simms, John Fitzmaurice Valliant, Alla Darwish
  • IGF-1R monoclonal antibodies and uses thereof
    Patent number: 11433148
    Abstract: The present invention relates to conjugates including a chelating moiety of a metal complex thereof and a therapeutic or targeting moiety, methods for their production, and uses thereof.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: September 6, 2022
    Assignee: Centre for Probe Development and Commercialization
    Inventors: Eric Steven Burak, John Richard Forbes, Matthew David Burr Moran, Ryan Wayne Simms, John Fitzmaurice Valliant, Alla Darwish
  • PHARMACOKINETIC ENHANCEMENTS OF BIFUNCTIONAL CHELATES AND USES THEREOF
    Publication number: 20220054664
    Abstract: The present invention relates to conjugates including a chelating moiety of a metal complex thereof and a therapeutic or targeting moiety, methods for their production, and uses thereof.
    Type: Application
    Filed: November 2, 2021
    Publication date: February 24, 2022
    Inventors: Eric Steven Burak, Stuart James Mahoney, Ryan Wayne Simms, John Fitzmaurice Valliant, Alla Darwish
  • Pharmacokinetic enhancements of bifunctional chelates and uses thereof
    Patent number: 11191854
    Abstract: The present invention relates to conjugates including a chelating moiety of a metal complex thereof and a therapeutic or targeting moiety, methods for their production, and uses thereof.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: December 7, 2021
    Assignee: Centre for Probe Development and Commercialization
    Inventors: Eric Steven Burak, Stuart James Mahoney, Ryan Wayne Simms, John Fitzmaurice Valliant, Alla Darwish
  • RESIDUALIZING LINKERS AND USES THEREOF
    Publication number: 20210060190
    Abstract: The present invention relates to conjugates including a residualizing linker, methods for their production, and uses thereof.
    Type: Application
    Filed: July 24, 2020
    Publication date: March 4, 2021
    Inventors: John Fitzmaurice Valliant, Eric Steven Burak, Neil Grant Cockbum, Alla Darwish, Joe Adamson Drewry, John Richard Forbes, Meiduo Hu, Ryan Wayne Simms, Karin Ann Stephenson, Tao Wu
  • Residualizing linkers and uses thereof
    Patent number: 10758636
    Abstract: The present invention relates to conjugates including a residualizing linker, methods for their production, and uses thereof.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: September 1, 2020
    Assignee: CENTRE FOR PROBE DEVELOPMENT AND COMMERCIALIZATION
    Inventors: John Fitzmaurice Valliant, Eric Steven Burak, Neil Grant Cockburn, Alla Darwish, Joel Adamson Drewry, John Richard Forbes, Meiduo Hu, Ryan Wayne Simms, Karin Ann Stephenson, Tao Wu
  • RESIDUALIZING LINKERS AND USES THEREOF
    Publication number: 20160279272
    Abstract: The present invention relates to conjugates including a residualizing linker, methods for their production, and uses thereof.
    Type: Application
    Filed: November 12, 2014
    Publication date: September 29, 2016
    Inventors: John Fitzmaurice VALLIANT, Eric Steven BURAK, Neil Grant COCKBURN, Alla DARWISH, Joel Adamson DREWRY, John Richard FORBES, Meiduo HU, Ryan Wayne SIMMS, Karin Ann STEPHENSON, Tao WU
  • METHODS OF PREPARING TRIAZOLE-CONTAINING RADIOIODINATED COMPOUNDS
    Publication number: 20140065070
    Abstract: The present application relates to methods of preparing radiohalogenated compounds, to compounds useful in such methods and to radiohalogenated compounds useful for imaging and/or therapy.
    Type: Application
    Filed: August 28, 2013
    Publication date: March 6, 2014
    Applicant: MCMASTER UNIVERSITY
    Inventors: John Valliant, Alla Darwish, Stephanie Rathmann, Afaf Genady