Abstract: An improved allergen-barrier cover for completely surrounding an allergen-carrier article, such as bedding, is provided. The cover is formed from a multilayer fabric such as an SMS fabric that allows passage of air, but blocks the passage of allergens and liquid water. This fabric is formed into an enclosure by thermally welding any seams necessary to provide a enclosure which completely encases the allergen-carrier article except for an opening sufficient to allow insertion of the allergen-carrier article into the enclosure. The cover also includes a closure in the form of a plastic seal made up of two portions: a first portion having at least two parallel ridges spaced apart from one another by a first distance and a second portion comprising at least two parallel grooves spaced apart from one another by the same distance as the parallel ridges and sized to receive the at least two parallel ridges in sealing engagement.