Abstract: Disclosed herein, inter alia, are substrates, kits, and efficient methods of preparing and sequencing two or more regions of a double-stranded polynucleotide.

Abstract: A robotically enabled teleoperated system can include a controller and a robotic tool capable of manipulation by the controller. The controller can include a handle, a gimbal and a positioning platform. The handle can be configured for actuation by an operator to cause a corresponding manipulation of the robotic tool. The gimbal can include a joint and a load cell. The joint can be configured to be manipulated based on an impedance control, such that manipulation of the gimbal causes a corresponding manipulation of the robotic tool based on a displacement of the joint. A portion of the positioning platform can be configured to be manipulated based on an admittance control, such that manipulation of the positioning platform causes a corresponding manipulation of the robotic tool based on a force imparted on the controller and measured by the load cell.

Abstract: Disclosed herein is a system for treating a magnesium or a magnesium alloy substrate comprising: a first pretreatment composition comprising a fluorometallic acid and free fluoride in an amount of 10 ppm to 500 ppm based on total weight of the first pretreatment composition and having a pH of 1.0 to 4.0; and a second pretreatment composition comprising a lanthanide series metal, the second pretreatment composition being substantially free of peroxide. Also disclosed are methods of treating a magnesium or magnesium alloy substrate. Treated magnesium and magnesium alloy substrates also are disclosed.

Abstract: An example operation includes one or more of receiving a request into a transport network comprising at least one transport for a proposed use of personal data associated with the at least one transport prior to the at least one transport entering an area; receiving into the transport network a deletion time of the personal data, prior to the at least one transport entering the area; providing, from the transport network an acknowledgement of the deletion time; and providing, from the transport network, the personal data when the at least one transport is in the area based on the received acknowledgement. This enables an occupant of a transport to share personal data relating to the transport with confidence that the data will be deleted by an agreed time.

Abstract: An external filter assembly is shown having a slotted filter section, including an optional upper collar attached below the mounting member, and lower collar attached below the bottom cap of a lower filter element, where each collar includes a plurality of extensions containing magnets. Specifically, in the case of each extension, a bore is formed longitudinally within the extension, and a diametrically magnetic rare earth (neodymium) high-temperature rated magnet is permanently installed within the bore. Thus, with magnets installed in all of the extensions, metal debris passing through the assembly at any location, whether the upper collar or lower collar, is likely to be attracted to and retained by the extensions.

Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: Air valves, such as wastegates, utilize a shaft that rotates within a bushing system. Conventional deposition processes limit the thickness of the wear material between the shaft and bushing system. Accordingly, embodiments disclosed herein utilize one or more coating sleeves that are press-fit onto the shaft. This enables a thicker layer of wear material to be applied to the shaft, thereby improving the longevity and durability of the air valve, while also simplifying the manufacturing process. Embodiments may also utilize one or more anti-rotation features, such as a dowel or axial protrusion, and/or may utilize snap ring(s) to prevent axial sliding of the coating sleeve(s).

Abstract: A component for a vehicle interior may comprise a light guide to allow light transmission from a light source, and a cover to cover the light guide. The light guide may comprise an icon or indicator and the cover may comprise a depression or indentation in an inner surface of the cover. The icon/indicator of the light guide may comprise a light-transmissive resin material configured to fit within the depression/indentation in the cover. The icon/indicator may be presented when illuminated and hidden by the cover when not illuminated. The cover may comprise a polymer material coupled to the light guide. The cover may present a user interface. A surface of the cover may comprise an information region and/or a decorative region. The component may comprise a steering wheel, console, floor console, center console, instrument panel, door panel, dashboard, display, armrest, or cockpit.

Abstract: A first framework uses an actor pattern and a second framework uses an event based asynchronous pattern in a computing system. The computing system runs a compatibility layer configured to enable interoperation between the first framework and the second framework. A first message for a first component associated with the first framework is mapped to a second message that provides a corresponding result for a second component associated with the second framework.

Abstract: Novel quinazolinones useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.

Abstract: A shroud of a vane of a turbine is provided. The shroud includes a shroud main body comprising a first wall having a gas-passage face facing a hot gas passage of the turbine and a cooling face facing opposite to the hot gas passage, a shroud edge disposed on a circumference of the shroud main body to surround the shroud main body, the shroud edge comprising a shroud edge passage therein, and an impingement box disposed to face the cooling face of the first wall so as to be spaced apart from the cooling face of the first wall. The impingement box comprises a cooling air inlet to introduce a cooling air from the shroud edge passage into an inside of the impingement box, and an impingement air hole configured to jet the introduced cooling air to the cooling face of the first wall to cool the cooling face of the first wall.

Abstract: The present invention relates to a new process for manufacturing a silicon carbide (SiC) coated body by depositing SiC in a chemical vapor deposition method using dimethyldichlorosilane (DMS) as the silane source on a graphite substrate. A further aspect of the present invention relates to the new silicon carbide coated body, which can be obtained by the new process of the present invention, and to the use thereof for manufacturing articles for high temperature applications, susceptors and reactors, semiconductor materials, and wafer.

Abstract: Disclosed herein are novel lipids that can be used in combination with other lipid components, such as helper lipids, structural lipids, and cholesterols, to form lipid nanoparticles for delivery of therapeutic agents, such as nucleic acids (e.g., circular polynucleotides), both in vitro and in vivo.

Abstract: The embodiments disclose an apparatus including an eyewear pupilometer for detecting, measuring and processing a wearer's pupil movement and size, for detecting and processing retinal images, for detecting and processing a wearer's field of view, for broadcasting alerts, for pre-diagnostic screening, for overriding vehicle operation and for measuring, recording and transmitting circadian responses, at least one eyewear pupilometer module including a lens fiber optic camera module, an image processor module, a retinal image infrared detector module, an outward camera module, at least one alert module, an alert light and message projector, a WI-FI module, an automated pullover module, an automated steering module, fiber optic & data cables, a contact lens pupilometer image, sensor and processor module, and at least one eyewear pupilometer module coupled to and/or embedded into eyewear frames and lenses, contact lenses, a vehicle wind shield and protective covers for hand held devices and laptop computers.

Abstract: A device for keeping connected pipe ends from loosening or separating, especially if they are of different diameters, wherein there is a four-piece clamp consisting of four identical semicircular pieces that when joined together creates a set of circular pieces. The set of circular pieces interlock at the ends of a pipe creating a four-piece clamp.

Abstract: The present invention relates to a non-destructive method comprising placing a tissue sample on a porous matrix, centrifuging the tissue sample under a negative pressure, applying a vacuum on the tissue sample, and collecting extracted extracellular vesicles from the tissue sample. The method does not cause physical rupturing of the tissue sample and maintains integrity of the tissue sample for further histopathological analysis. Moreover, the invention also provides a method of inducing an immune response of a host by immune sensitization using harvested extracellular vesicles.

Abstract: A photovoltaic powered flexible electronic device comprising a flexible photovoltaic module, electrodes (such as anode and cathode) incorporated into the flexible photovoltaic module, wherein the electrodes are at least partially exposed, and a flexible circuit board, wherein the flexible circuit board is attached to one of the following: (a) the flexible photovoltaic module, (b) a flexible substrate located on the flexible photovoltaic module, and (c) an adhesive located on the flexible photovoltaic module, the flexible circuit board comprising: a recharging circuit, wherein the recharging circuit is electrically connected to the cathode and anode electrodes; an energy storage unit; and a radio emitting device, wherein the photovoltaic powered flexible electronic device comprises a Young's Modulus of 150 GPa or less. The flexible electronic device can be a flexible organic electronic device.

Abstract: The invention provides a light generating system (1000), wherein the light generating system (1000) is configured to generate system light (1001) having a controllable spectral power distribution and intensity, wherein in an operational mode the light generating system (1000) is configured to generate during a first time period P1, a first spectral power distribution E1, and during a second time period P2, later in time than the first period P1, a second spectral power distribution E2, wherein: (A) the controllable spectral power distribution comprises (a) a first spectral range ?1 having one or more wavelengths in the blue, and having a primary first spectral power SP(P1, ?1) during the first time period P1 and a secondary first spectral power SP(P2, ?1) during the second time period P2, (b) a second spectral range ?2 having one or more wavelengths in the green, and having a primary second spectral power SP(P1, ?2) during the first time period P1 and a secondary second spectral power SP(P2, ?2) during the se

Abstract: Techniques including a system and method for processing insurance documents are provided. The techniques may involve the use of a system. The system may include a component configured to process a plurality of input document entities. The system may include a routing component configured to process the plurality of input document entities, wherein the routing component is configured to determine one or more workflows for processing at least one of the plurality of document entities. The system may include a workflow management component configured to process the at least one of the plurality of document entities.

Abstract: A portable golf training device that attaches to the brim of a golfer's cap to limit head movement and body sway during golf swings. The device can be adjusted to accommodate the height of a user and can be utilized with the base under a golf mat, on various ground surfaces such as in the sand, on driving range surfaces, or on grassy surfaces by use of removable, interchangeable bases.