Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to a method of realizing volume saving for consumers through the use of a web based system. In the claimed method at least one consumer and at least one supplier registers in a web based medium. Each is dynamically presented with a technological environment that is customized to perform at least one consumer task or at least one supplier task. The at least one consumer utilizes the technological environment to express an interest to enter into at least one consumer transaction, and to subordinate or subject this consumer transaction to at least one prerequisite condition. The disclosed technological environment also enables the at least one supplier to list at least one supplying transaction and subject such transaction to a perquisite condition or to a prerequisite minimum quantity condition. The present invention also discloses a mediator step, which is responsible for facilitating the meeting of the minds between at least one consumer an the at least one supplier.