Abstract: The present invention provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.

Abstract: A process using a particular catalyst in the dehydrogenation of an alkyl aromatic compound, e.g., ethylbenzene, to form a vinyl aromatic compound, e.g., styrene. The catalyst comprises a calcination product of (a) at least one iron oxide; (b) at least one carbonate, bicarbonate, oxide or hydroxide of potassium and/or cesium; (c) an oxide, carbonate, nitrate or hydroxide of cerium, or a mixture of at least two thereof; (d) an hydraulic cement; (e) an hydroxide, carbonate, bicarbonate, acetate, oxalate, nitrate, or sulfate of sodium, in an amount sufficient to provide from 0.2 to 10 percent sodium, calculated as sodium oxide, by weight of the calcined catalyst; and (f) a carbonate, sulfate, or hydroxide, of calcium or a mixture of at least two thereof, in an amount sufficient to provide from 1.5 to 20 percent calcium, calculated as calcium oxide, by weight of the calcined catalyst. The catalyst has improved moisture stability compared to catalysts in which at least one of (e) or (f) is not met.

Abstract: A calcined dehydrogenation catalyst comprising at least one sodium compound and one calcium compound is disclosed. The catalyst exhibits improved moisture stability as evidenced by improved crush strength and resistance to swelling and cracking.

Abstract: A dehydrogenation catalyst containing iron and promoted with potassium and cerium has been shown to have improved activity when a copper compound is added thereto as a component. The improvement in activity is obtained without substantially sacrificing selectivity.

Abstract: An improved dehydrogenation catalyst, useful in converting alkylaromatics to alkenylaromatics, e.g. ethylbenzene to styrene, has been discovered which contains lower amounts of iron and relatively larger amounts of cerium and potassium than those known to the art.

Abstract: A probabilistic learning element for performing task independent sequential pattern recognition. The element receives sequences of objects and outputs sequences of recognized states composed of objects. A plurality of memory elements are utilized to store received objects in sequence and for storing in context learned information including previously learned states, objects contained in previously learned states, positional information for each object in a learned state and other predetermined types of knowledge relating to previously learned states and objects contained therein. The element correlates sequences of received objects with learned information relating to previously learned states for providing conditional probabilities to possible sequences of recognized states. The most likely state sequence is determined and outputted as a recognized sequence when the element detects that a state has ended.

Abstract: A continuous speech recognition system includes a plurality of processors doing template comparisons of speech data. Each processor has an associated memory shared with the other processors by direct memory access (DMA) through a shared data bus. The DMA circuitry is distributed between the processors to eliminate redundancy, since if each processor had a full DMA circuit, one of the circuits would be idle when the processors communicated.