Abstract: Provided herein are compounds (e.g., compounds of Formulae (A-I), (B-I), (C-I)), and pharmaceutically acceptable salts, stereoisomers, tautomers, isotopically labeled derivatives, solvates, hydrates, polymorphs, co-crystals, and prodrugs thereof, pharmaceutical compositions thereof, and kits comprising the same. The compounds provided herein are degraders of GRK2 proteins and are therefore useful for, e.g., treating and/or preventing diseases (e.g., cancer) in a subject, for inhibiting tumor growth in a subject, for inhibiting the activity of GRK2 and/or degrading a GRK2 protein in vitro or in vivo, etc. In certain embodiments, the compounds provided herein are selective for GRK2. Also provided herein are methods and synthetic intermediates useful in the preparation of compounds described herein.

Abstract: The present invention provides methods and systems that provide for reliable, convenient, and noninvasive assessment of hydration status. The methods and apparatuses can use the temporal sequence of the aortic value opening and closing along with the user's body position to derive parameters that determine the hydration status of the user. The user can use this information to make near-term lifestyle changes that can improve physical performance, health, and general wellbeing.

Abstract: An optical communication system, device, and method are disclosed. An illustrative optical communication system is disclosed to include a carrier Integrated Circuit (IC) chip having an amplifier circuit, a bias plane, and a ground plane. The amplifier circuit, bias plane, and the ground plane may each operate at or above a nominal voltage of zero volts. A laser diode may be integrated with an electro-absorption modulator into a single IC chip, where the laser diode is mounted on the carrier IC chip and is electrically connected with the amplifier circuit of the carrier IC chip through a bond wire.

Abstract: A vehicle-attached lifting device and tool support is provided. The device comprises a dual-rail frame supported in an upright configuration by the vehicle tow hitch, wherein an internal subassembly support frame is positioned between the rails for the purposes of supporting different lifting and tool support subassemblies. Along the sides of the upright frame is a pair of ground support members that extend downward towards the ground to support the frame during operation, preventing the load from compressing the vehicle suspension or damaging the same. A winch controls the vertical positioning of the support frame within the dual-rail frame, which controls the position of a lifting or tool support subassembly. Many subassemblies are contemplated for use with the present invention for the purposes of assisting a user without requiring manual input therefrom. The device can also adjust with relation to the vehicle using different trailer hitch attachments.

Abstract: Various exemplary embodiments relate to a method performed by a network policy node. The method may include: translating a policy into a plurality of rule objects, the policy including an applicability condition and one or more action rules; generating a selection rule table based on the applicability condition of one or more policies; generating an action rule table from the one or more action rules of an applicable policy, an action rule including an action condition and an action path; determining a set of applicable policies by evaluating the selection rule table using a rules engine; and selecting an action path by evaluating the action rule table using the rules engine. Various exemplary embodiments relate to a network policy node including a scanner that generates rules objects and rule tables based on one or more policies, a context information storage, and a rules engine that evaluates rule tables.

Abstract: Collapsible, adjustable scuba fin with a cam lock feature. The blades of the fin are set on an enclosed track in the foot plate which allows the blades to be extended to create a fin of variable surface area for different swimming conditions or retracted under the foot plate for walking. The blades can be locked in place by the cam lock which is attached to the foot plate by means of a screw and foot pocket by means of an adjustable pull lanyard. The foot pocket and heel hilt can be adjusted to accommodate feet and footwear of varying size, and style allowing a single fin to fit multiple individuals and requirements. A T-bolt slider set in the foot plate can be rotated or removed to access the space between the blades allowing for the clearing of debris.

Abstract: An optical communication system, a transmitter, a receiver, and methods of operating the same are provided. In particular, a transmitter is disclosed as being configured to encode optical signals in accordance with a multi-level coding scheme. The receiver is configured to provide skew correction to the optical signals received from the transmitter by dividing a received signal into separate level-specific components and sampling each of the components with distinct sampling blocks.

Abstract: A powered auger support device is provided having connection to a vehicle, a trailer hitch receiver on a vehicle, or the bed of a trailer, whereby a powered auger is slideably supported along an upright rail by way of a winch controlled by an operator. The device comprises a support structure having an upright rail, an auger support frame, and a pulley and winch system for raising and lowering the auger support frame. The auger support frame supports the handles of a stand-along auger and is pivotably supported along the rail, permitting the support frame to rotate with respect to the frame for placing the auger working end at different angles or in a horizontally stowed position. An embodiment of the upright rail contemplates a rotational hinge that places the auger support frame outside of the vehicle wheel tracks or outside of the bed of a trailer during use.

Abstract: Collapsible, adjustable scuba fin with a cam lock feature. The blades of the fin are set on an enclosed track in the foot plate which allows the blades to be extended to create a fin of variable surface area for different swimming conditions or retracted under the foot plate for walking. The blades can be locked in place by the cam lock which is attached to the foot plate by means of a screw and foot pocket by means of an adjustable pull lanyard. The foot pocket and heel hilt can be adjusted to accommodate feet and footwear of varying size, and style allowing a single fin to fit multiple individuals and requirements. A T-bolt slider set in the foot plate can be rotated or removed to access the space between the blades allowing for the clearing of debris.

Abstract: A rules systems version coordination method is disclosed for the initiation of a rules system version and the coordination of the rules system version with other rules system versions which may be available. Particularly, the rules system versions are coordinated so that one-and-only-one is in the Active State i.e. the state in which the Policy and Charging Rules Node (PCRN) is deriving its set of policies; rules system versions may only be promoted to the Active State from a Release State; and rules system versions may only be modified when in a Draft State, from which they may be promoted to the Release State. The rules systems version coordination method is particularly useful for providing a buffer state between rules system versions undergoing modification and the rules system version currently in service.

Abstract: An optical communication system, a transmitter, a receiver, and methods of operating the same are provided. In particular, a transmitter is disclosed as being configured to encode optical signals in accordance with a multi-level coding scheme. The receiver is configured to provide receive and decode to the optical signals received from the transmitter. One or both of the receiver and transmitter are configured to compensate for non-idealities or non-linearities introduced into the communication system by optical components of the system.

Abstract: An optical communication system, a transmitter, a receiver, and methods of operating the same are provided. In particular, a transmitter is disclosed as being configured to encode optical signals in accordance with a multi-level coding scheme. The receiver is configured to provide skew correction to the optical signals received from the transmitter by dividing a received signal into separate level-specific components and sampling each of the components with distinct sampling blocks.

Abstract: An optical communication system, a transmitter, a receiver, and methods of operating the same are provided. In particular, a transmitter is disclosed as being configured to encode optical signals in accordance with a multi-level coding scheme. The receiver is configured to provide receive and decode to the optical signals received from the transmitter. One or both of the receiver and transmitter are configured to compensate for non-idealities or non-linearities introduced into the communication system by optical components of the system.

Abstract: Various exemplary embodiments relate to a method performed by a policy and charging rules node for managing usage of a subscriber. The method may include: defining a primary metering policy having a first applicability condition and a first quota; defining a secondary metering policy having attributes including a second applicability condition and at least one inherited attribute that references an attribute of the primary metering policy; determining that the second metering policy is applicable when the first applicability condition and the second applicability condition are true; selecting the secondary metering policy as an active metering policy; and managing subscriber usage according to the attributes of the secondary metering policy.

Abstract: Various embodiments relate to a system and related method for managing a connection of a user device to a communications network. Various embodiments relate to a Policy and Charging Rules Node (PCRN) receiving a user requests through multiple serving gateways. The PCRN may assign one of the serving gateways as a primary serving gateway when the serving gateway sends a Gateway Control Session that binds to an IP-CAN session established in the PCRN. When the PCRN receives a subsequent message from another serving gateway, the PCRN may reassign the new serving gateway as primary when its Gateway Control Session matches. The PCRN may then mark the former serving gateway as pending termination and signal the marked gateway to terminate. After sending rules to serving gateways not pending termination, the PCRN may delete those serving gateways marked for termination.

Abstract: A vehicle-attached lifting device and tool support is provided. The device comprises a dual-rail frame supported in an upright configuration by the vehicle tow hitch, wherein an internal subassembly support frame is positioned between the rails for the purposes of supporting different lifting and tool support subassemblies. Along the sides of the upright frame is a pair of ground support members that extend downward towards the ground to support the frame during operation, preventing the load from compressing the vehicle suspension or damaging the same. A winch controls the vertical positioning of the support frame within the dual-rail frame, which controls the position of a lifting or tool support subassembly. Many subassemblies are contemplated for use with the present invention for the purposes of assisting a user without requiring manual input therefrom. The device can also adjust with relation to the vehicle using different trailer hitch attachments.

Abstract: A video control server includes a central processing unit and a memory storing executable instructions to receive control station commands, update state information specifying how network video sources are to be assessed and displayed by a client, and send the state information to the client.

Abstract: A rules systems version coordination method is disclosed for the initiation of a rules system version and the coordination of the rules system version with other rules system versions which may be available. Particularly, the rules system versions are coordinated so that one-and-only-one is in the Active State i.e. the state in which the Policy and Charging Rules Node (PCRN) is deriving its set of policies; rules system versions may only be promoted to the Active State from a Release State; and rules system versions may only be modified when in a Draft State, from which they may be promoted to the Release State. The rules systems version coordination method is particularly useful for providing a buffer state between rules system versions undergoing modification and the rules system version currently in service.

Abstract: A powered auger support device is provided having connection to a vehicle, a trailer hitch receiver on a vehicle, or the bed of a trailer, whereby a powered auger is slideably supported along an upright rail by way of a winch controlled by an operator. The device comprises a support structure having an upright rail, an auger support frame, and a pulley and winch system for raising and lowering the auger support frame. The auger support frame supports the handles of a stand-along auger and is pivotably supported along the rail, permitting the support frame to rotate with respect to the frame for placing the auger working end at different angles or in a horizontally stowed position. An embodiment of the upright rail contemplates a rotational hinge that places the auger support frame outside of the vehicle wheel tracks or outside of the bed of a trailer during use.

Abstract: A rules systems version coordination method is disclosed for the initiation of a rules system version and the coordination of the rules system version with other rules system versions which may be available. Particularly, the rules system versions are coordinated so that one-and-only-one is in the Active State i.e. the state in which the Policy and Charging Rules Node (PCRN) is deriving its set of policies; rules system versions may only be promoted to the Active State from a Release State; and rules system versions may only be modified when in a Draft State, from which they may be promoted to the Release State. The rules systems version coordination method is particularly useful for providing a buffer state between rules system versions undergoing modification and the rules system version currently in service.