Abstract: Methods and systems for determining computer optimization-based regimens and/or plans and/or programs for diet and health management are presented. A regimen and/or plan and/or program is generated by a computer (i) obtaining for an individual, a nutritional-based metabolic response as a function of time associated with a set of nutritional components, (ii) obtaining for the individual, an exercise-based metabolic response as a function of time associated a set of exercises available for performance by the individual, (iii) optimizing using computer optimization applied to the nutrition-based metabolic responses and the exercise-based metabolic responses, to determine a regimen defining for a time interval a sequence of one or more nutritional components to be ingested by the individual, and a sequence of one or more exercises to be performed by the individual, whereby one or more individual-based parameters are maintained in a predetermined range.