Patents by Inventor ALLISON L. CRAMB
ALLISON L. CRAMB has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11796786Abstract: A confocal microscope for imaging tissue having an imaging head for capturing optically formed microscopic sectional images of tissue samples, a platform upon which is disposed a linear stage for moving the imaging head along a vertical dimension, and a rotary stage to rotate the linear stage and imaging head about the vertical dimension. A mounting arm couples the imaging head to the linear stage to adjust tilt of the imaging head and to rotate the imaging head about a normal axis perpendicular to an optical axis of an objective lens of the imaging head. In a first mode of operation, the imaging head is positioned to image an ex-vivo or in-vivo tissue sample upon the platform, such as ex-vivo tissue sample mounted upon a movable specimen stage, and in a second mode of operation the imaging head is positioned to image an in-vivo tissue sample beside the platform.Type: GrantFiled: March 1, 2021Date of Patent: October 24, 2023Assignee: CALIBER IMAGING & DIAGNOSTICS, INC.Inventors: Allison L. Cramb, Christopher C. Distasio, William J. Fox, Steven Ridge, Simon C. Watkins
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Patent number: 11681133Abstract: A system having a macroscopic imager, a microscopic imager, and a stage for moving a substrate supporting ex-vivo tissue with respect to each of the imagers to enable the macroscopic imager to capture macroscopic images, and the microscopic imager to capture optically formed sectional microscopic images on or within the tissue, when presented to the tissue, via the optically transparent material of the substrate. A computer system controls movement of the stage, and receives the macroscopic and microscopic images. A display is provided for displaying the macroscopic and microscopic images when received by the computer system. The tissue is verified as being in an orientation at least substantially flush against the upper surface of the substrate by being in focus in displayed macroscopic images prior to imaging by the microscopic imager, and if needed, any portion of the tissue unfocused is manually positioned until desired tissue orientation is achieved.Type: GrantFiled: March 16, 2022Date of Patent: June 20, 2023Assignee: CALIBER IMAGING & DIAGNOSTICS, INC.Inventors: William J. Fox, Christopher C. Distasio, Allison L. Cramb, Paul Hemmer, Christopher E. Wagner, Keith A. Hadley, Elizabeth Kiefer
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Publication number: 20220206277Abstract: A system having a macroscopic imager, a microscopic imager, and a stage for moving a substrate supporting ex-vivo tissue with respect to each of the imagers to enable the macroscopic imager to capture macroscopic images, and the microscopic imager to capture optically formed sectional microscopic images on or within the tissue, when presented to the tissue, via the optically transparent material of the substrate. A computer system controls movement of the stage, and receives the macroscopic and microscopic images. A display is provided for displaying the macroscopic and microscopic images when received by the computer system. The tissue is verified as being in an orientation at least substantially flush against the upper surface of the substrate by being in focus in displayed macroscopic images prior to imaging by the microscopic imager, and if needed, any portion of the tissue unfocused is manually positioned until desired tissue orientation is achieved.Type: ApplicationFiled: March 16, 2022Publication date: June 30, 2022Inventors: WILLIAM J. FOX, CHRISTOPHER C. DISTASIO, ALLISON L. CRAMB, PAUL HEMMER, CHRISTOPHER E. WAGNER, KEITH A. HADLEY, ELIZABETH KIEFER
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Patent number: 11280990Abstract: A system having a macroscopic imager, a microscopic imager, and a stage for moving a substrate supporting ex-vivo tissue with respect to each of the imagers to enable the macroscopic imager to capture macroscopic images, and the microscopic imager to capture optically formed sectional microscopic images on or within the tissue, when presented to the tissue, via the optically transparent material of the substrate. A computer system controls movement of the stage, and receives the macroscopic and microscopic images. A display is provided for displaying the macroscopic and microscopic images when received by the computer system. The tissue is verified as being in an orientation at least substantially flush against the upper surface of the substrate by being in focus in displayed macroscopic images prior to imaging by the microscopic imager, and if needed, any portion of the tissue unfocused is manually positioned until desired tissue orientation is achieved.Type: GrantFiled: February 26, 2019Date of Patent: March 22, 2022Assignee: CALIBER IMAGING & DIAGNOSTICS, INC.Inventors: William J. Fox, Christopher C. Distasio, Allison L. Cramb, Paul Hemmer, Christopher E. Wagner, Keith A. Hadley, Elizabeth Kiefer
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Publication number: 20210181493Abstract: A confocal microscope for imaging tissue having an imaging head for capturing optically formed microscopic sectional images of tissue samples, a platform upon which is disposed a linear stage for moving the imaging head along a vertical dimension, and a rotary stage to rotate the linear stage and imaging head about the vertical dimension. A mounting arm couples the imaging head to the linear stage to adjust tilt of the imaging head and to rotate the imaging head about a normal axis perpendicular to an optical axis of an objective lens of the imaging head. In a first mode of operation, the imaging head is positioned to image an ex-vivo or in-vivo tissue sample upon the platform, such as ex-vivo tissue sample mounted upon a movable specimen stage, and in a second mode of operation the imaging head is positioned to image an in-vivo tissue sample beside the platform.Type: ApplicationFiled: March 1, 2021Publication date: June 17, 2021Inventors: ALLISON L. CRAMB, CHRISTOPHER C. DISTASIO, WILLIAM J. FOX, STEVEN RIDGE, SIMON C. WATKINS
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Patent number: 10935778Abstract: A confocal microscope for imaging tissue having an imaging head for capturing optically formed microscopic sectional images of tissue samples, a platform upon which is disposed a linear stage for moving the imaging head along a vertical dimension, and a rotary stage to rotate the linear stage and imaging head about the vertical dimension. A mounting arm couples the imaging head to the linear stage to adjust tilt of the imaging head and to rotate the imaging head about a normal axis perpendicular to an optical axis of an objective lens of the imaging head. In a first mode of operation, the imaging head is positioned to image an ex-vivo or in-vivo tissue sample upon the platform, such as ex-vivo tissue sample mounted upon a movable specimen stage, and in a second mode of operation the imaging head is positioned to image an in-vivo tissue sample beside the platform.Type: GrantFiled: November 12, 2017Date of Patent: March 2, 2021Assignee: CALIBER IMAGING & DIAGNOSTICS, INC.Inventors: Allison L. Cramb, Christopher C. Distasio, William J. Fox, Steven Ridge, Simon C. Watkins
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Patent number: 10514532Abstract: A confocal microscope is provided having an imaging head with an optical system for capturing optically formed microscopic sectional images of a sample, and a boom stand having a platform, a shaft which extends from the platform, and an arm which extends from the shaft, where such arm is coupled to the imaging head. The imaging head has a plurality of degrees of freedom of motion in positioning the arm relative to the shaft, and the imaging head relative to the arm, so that the imaging head in a first mode can be moved to image a first sample, such as ex-vivo tissue specimen mounted on a stage, disposed upon the platform, and in a second mode the imaging head can be moved to image a second sample, such as in-vivo issue, disposed away from or beside the platform.Type: GrantFiled: September 27, 2016Date of Patent: December 24, 2019Assignee: CALIBER IMAGING & DIAGNOSTICS, INC.Inventors: Allison L. Cramb, Christopher C. Distasio, William J. Fox, Steven Ridge, Christopher J. Lundgren
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Patent number: 10433784Abstract: A system is provided having a guide member with features, such as grid and axes, which spatially correlate to tissue with a lesion adjacent the guide member, and a template device upon the tissue aligned with the features having a first aperture over the guide member, and a second aperture over the tissue with the lesion. A microscope captures one or more images of the tissue via the second aperture at one or more locations each spatially correlated with a location selected or being mapped along the guide member in the first aperture. Prior to imaging and template device placement, marks are recorded along the guide member when, as part of a tracing sheet, it is positioned in a folded state over the lesion. When returned to an unfolded state, the guide member once removed from the tracing guide sheet is positioned for use with the template device and microscope.Type: GrantFiled: May 5, 2015Date of Patent: October 8, 2019Assignee: Caliber Imaging & Diagnostics, Inc.Inventors: Christi Alessi Fox, Allison L. Reece, Allison L. Cramb, Aleksandar Sekulic, David L. Swanson
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Publication number: 20190265456Abstract: A system having a macroscopic imager, a microscopic imager, and a stage for moving a substrate supporting ex-vivo tissue with respect to each of the imagers to enable the macroscopic imager to capture macroscopic images, and the microscopic imager to capture optically formed sectional microscopic images on or within the tissue, when presented to the tissue, via the optically transparent material of the substrate. A computer system controls movement of the stage, and receives the macroscopic and microscopic images. A display is provided for displaying the macroscopic and microscopic images when received by the computer system. The tissue is verified as being in an orientation at least substantially flush against the upper surface of the substrate by being in focus in displayed macroscopic images prior to imaging by the microscopic imager, and if needed, any portion of the tissue unfocused is manually positioned until desired tissue orientation is achieved.Type: ApplicationFiled: February 26, 2019Publication date: August 29, 2019Inventors: WILLIAM J. FOX, CHRISTOPHER C. DISTASIO, ALLISON L. CRAMB, PAUL HEMMER, CHRISTOPHER E. WAGNER, KEITH A. HADLEY, ELIZABETH KIEFER
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Publication number: 20180136448Abstract: A confocal microscope for imaging tissue having an imaging head for capturing optically formed microscopic sectional images of tissue samples, a platform upon which is disposed a linear stage for moving the imaging head along a vertical dimension, and a rotary stage to rotate the linear stage and imaging head about the vertical dimension. A mounting arm couples the imaging head to the linear stage to adjust tilt of the imaging head and to rotate the imaging head about a normal axis perpendicular to an optical axis of an objective lens of the imaging head. In a first mode of operation, the imaging head is positioned to image an ex-vivo or in-vivo tissue sample upon the platform, such as ex-vivo tissue sample mounted upon a movable specimen stage, and in a second mode of operation the imaging head is positioned to image an in-vivo tissue sample beside the platform.Type: ApplicationFiled: November 12, 2017Publication date: May 17, 2018Inventors: ALLISON L. CRAMB, CHRISTOPHER C. DISTASIO, WILLIAM J. FOX, STEVEN RIDGE, SIMON C. WATKINS
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Patent number: D843429Type: GrantFiled: November 12, 2016Date of Patent: March 19, 2019Assignee: CALIBER IMAGING & DIAGNOSTICS, INC.Inventors: Allison L. Cramb, Christopher C. Distasio, William J. Fox, Benny Alexander, Steven Ridge, Anthony J. Roberto, Tyler W. Porter
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Patent number: D859486Type: GrantFiled: September 27, 2015Date of Patent: September 10, 2019Assignee: CALIBER IMAGING & DIAGNOSTICS, INC.Inventors: Allison L. Cramb, Christopher C. Distasio, William J. Fox, Benny Alexander, Steven Ridge, Anthony J. Roberto, Tyler W. Porter
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Patent number: D862552Type: GrantFiled: February 26, 2018Date of Patent: October 8, 2019Assignee: CALIBER IMAGING & DIAGNOSTICS, INC.Inventors: William J. Fox, Christopher E. Wagner, Allison L. Cramb