Abstract: Disclosed are kits and methods for detecting the presence of tumor sites that are active in tumor cell dissemination and uses thereof for determining the risk of tumor cells undergoing hematogenous metastasis, for assessing the prognosis of a subject undergoing treatment for a localized tumor, for determining a course of treatment for a localized tumor, and for identifying agents to treat or prevent hematogenous metastasis.

Abstract: In accordance with the embodiments herein, a method for displaying differences and similarities between tissue samples utilizing a reference database consisting of tissue images, image analysis features, and derived score from patient tissue samples assayed with a tissue-based test for the purpose of scoring said patient sample and guiding treatment based on said score. The method described herein utilizes digital image analysis of a tissue image of one or more tissue sections to extract features which generates a dataset mathematically representing the image. This dataset is then compared to the reference database to determine reference images with similar and different feature values. Those images are then displayed with the similar and different features highlighted.

Abstract: In accordance with the embodiments herein, a method for displaying differences and similarities between tissue samples utilizing a reference database consisting of tissue images, image analysis features, and derived score from patient tissue samples assayed with a tissue-based test for the purpose of scoring said patient sample and guiding treatment based on said score. The method described herein utilizes digital image analysis of a tissue image of one or more tissue sections to extract features which generates a dataset mathematically representing the image. This dataset is then compared to the reference database to determine reference images with similar and different feature values. Those images are then displayed with the similar and different features highlighted.

Abstract: Disclosed are kits and methods for detecting the presence of tumor sites that are active in tumor cell dissemination and uses thereof for determining the risk of tumor cells undergoing hematogenous metastasis, for assessing the prognosis of a subject undergoing treatment for a localized tumor, for determining a course of treatment for a localized tumor, and for identifying agents to treat or prevent hematogenous metastasis.

Abstract: The disclosure concerns a method for extracting spatial distribution statistics from patient tissue samples assayed with a tissue-based test for the purpose of scoring the patient tissue samples and guiding treatment based on the score(s). The method described herein utilizes digital image analysis of an image of one or more tissue sections to extract object-based (e.g., cells) features. The object-based features within the image of the tissue section is further processed using one or more algorithm processes to extract sophisticated spatial distribution features of one or more object type or sub-type in the tissue. Statistics describing the spatial distribution features are summarized to generate a patient-specific diagnostic score, and this score can be evaluated to guide patient treatment decisions.

Abstract: The present invention relates to bacteria-targeted contrast agents for magnetic resonance imaging (MRI). In particular, the present invention relates to bacteria targeted MRI contrast agents that can be used to detect bacteria in vivo or in vitro. In certain embodiments, the contrast agents comprise a metal chelate conjugated to at least two Zn-dipicolylamine groups.

Abstract: The present invention relates to bacteria-targeted contrast agents for magnetic resonance imaging (MRI). In particular, the present invention relates to bacteria targeted MRI contrast agents that can be used to detect bacteria in vivo or in vitro. In certain embodiments, the contrast agents comprise a metal chelate conjugated to at least two Zn-dipicolylamine groups.

Abstract: The present invention provides targeted Schiff base complexes. In particular the present invention provides biopolymer targeted transition metal complexes configured to inhibit the activity of targeted proteins, methods of synthesis thereof, and pharmaceutical compositions and uses thereof.

Abstract: The present invention provides targeted Schiff base complexes. In particular the present invention provides biopolymer targeted transition metal complexes configured to inhibit the activity of targeted proteins, methods of synthesis thereof, and pharmaceutical compositions and uses thereof.