Patents by Inventor Alma L. Burlingame
Alma L. Burlingame has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160168151Abstract: This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof.Type: ApplicationFiled: September 24, 2015Publication date: June 16, 2016Inventors: Masahiro Tanaka, Chao Zhang, Kevan M. Shokat, Alma L. Burlingame, Kirk Hansen, Raynard L. Bateman, Stephen G. DiMagno
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Publication number: 20150031881Abstract: This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof.Type: ApplicationFiled: February 21, 2014Publication date: January 29, 2015Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Masahiro Tanaka, Chao Zhang, Kevan M. Shokat, Alma L. Burlingame, Kirk Hansen, Raynard L. Bateman, Stephen G. DiMagno
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Publication number: 20120065154Abstract: This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof.Type: ApplicationFiled: January 28, 2011Publication date: March 15, 2012Applicant: The Regents of the University of CaliforniaInventors: Masahiro Tanaka, Chao Zhang, Kevan M. Shokat, Alma L. Burlingame, Kirk Hansen, Raynard L. Bateman, Stephen G. DiMagno
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Patent number: 7741021Abstract: Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonations indicates a difference between the first and second physiological conditions. Predetermined changes in physiological conditions are used to infer specific changes in O-sulfonation. Proteins are modified by introducing a predetermined change in O-sulfonation at a serine or threonine residue of the protein, and optionally, detecting a resultant change in O-sulfonation. These methods include introducing or increasing O-sulfonation, eliminating or reducing O-sulfonation; and derivatizing or substituting O-sulfonation.Type: GrantFiled: November 9, 2006Date of Patent: June 22, 2010Assignees: Regents of the University of California, Yeda Research and Development Co. Ltd. at the Weizmann Institute of ScienceInventors: Alma L. Burlingame, Katalin F. Medzihradszky, Zsuzsanna Darula, Eran Perlson, Michael Fainzilber, Robert J. Chalkley, Darren Tyson, Ralph A. Bradshaw
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Publication number: 20090181988Abstract: This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof.Type: ApplicationFiled: August 19, 2008Publication date: July 16, 2009Applicant: The Regents of the University of CaliforniaInventors: Masahiro Tanaka, Chao Zhang, Kevan M. Shokat, Alma L. Burlingame, Kirk Hansen, Raynard L. Bateman, Stephen G. DiMagno
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Patent number: 7429596Abstract: This invention generally relates to pyrazolo pyrimidine derivatives useful as inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. The invention further relates to pharmaceutical compositions and methods of preventing or treating disease with 1H-Pyrrolo[2.3-d]pyrimidine derivatives. More specifically, the invention relates to a 1H-Pyrrolo[2.Type: GrantFiled: June 18, 2004Date of Patent: September 30, 2008Assignee: The Regents of the University of CaliforniaInventors: Masahiro Tanaka, Chao Zhang, Kevan M. Shokat, Alma L. Burlingame, Kirk Hansen, Raynard L. Bateman, Stephen G. DiMagno
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Patent number: 7138228Abstract: Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonations indicates a difference between the first and second physiological conditions. Predetermined changes in physiological conditions are used to infer specific changes in O-sulfonation. Proteins are modified by introducing a predetermined change in O-sulfonation at a serine or threonine residue of the protein, and optionally, detecting a resultant change in O-sulfonation. These methods include introducing or increasing O-sulfonation, eliminating or reducing O-sulfonation; and derivatizing or substituting O-sulfonation.Type: GrantFiled: September 5, 2003Date of Patent: November 21, 2006Assignees: Regents of the University of California, Yeda Research and Development Co. Ltd. at the Weizmann Institute of ScienceInventors: Alma L. Burlingame, Katalin F. Medzihradszky, Zsuzsanna Darula, Eran Perlson, Michael Fainzilber, Robert J. Chalkley, Darren Tyson, Ralph A. Bradshaw
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Patent number: 6624288Abstract: This invention relates to relatively short peptides about 25-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogs to the naturally available peptides, and which include three cyclizing disulfide linkages and one or more &ggr;-carboxyglutamate residues.Type: GrantFiled: December 15, 1998Date of Patent: September 23, 2003Assignees: Cognetix, Inc., University of Utah Research FoundationInventors: Michael Fainzilber, Karel S. Kits, Alma L. Burlingame, Baldomero M. Olivera, Craig Walker, Maren Watkins, Reshma Shetty, Lourdes J. Cruz, Julita Imperial, Clark Colledge
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Patent number: 5965884Abstract: An Atmospheric Pressure Matrix-Assisted Laser Desorption Ionization (AP-MALDI) apparatus is for connecting to a mass spectrometer. This apparatus provides an ion source using matrix-assisted laser desorption and ionization at or near atmospheric pressure. The apparatus has non-destructive ion source having the characteristics of versatility, simplicity.Type: GrantFiled: June 4, 1998Date of Patent: October 12, 1999Assignee: The Regents of the University of CaliforniaInventors: Victor V. Laiko, Alma L. Burlingame
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Patent number: 5962294Abstract: DNA isolates coding for sialyltransferase which contain a conserved region of homology and methods of obtaining such DNA are provided, together with expression systems for recombinant production of sialyltransferase.Type: GrantFiled: August 4, 1993Date of Patent: October 5, 1999Assignees: The Regents of the University of California, Amgen, Inc.Inventors: James C. Paulson, Xiaohong Wen, Brian Livingston, William Gillespie, Sorge Kelm, Alma L. Burlingame, Katalin Medzihradszky
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Patent number: 5858751Abstract: DNA isolates coding for sialyltransferase which contain a conserved region of homology and methods of obtaining such DNA are provided, together with expression systems for recombinant production of the various sialyltransferases.Type: GrantFiled: July 12, 1995Date of Patent: January 12, 1999Assignee: The Regents of the University of CaliforniaInventors: James C. Paulson, Xiaohong Wen, Brian Livingston, Alma L. Burlingame, Katalin Medzihradszky, Sorge Kelm, William Gillespie