Abstract: A method for producing a composition comprising nanoparticles of a biologically active compound.

Abstract: A method for producing a composition comprising nanoparticles of a biologically active compound.

Abstract: A method for producing a composition comprising nanoparticles of a biologically active compound.

Abstract: Provided herein are engineered cells and methods for engineering cells to deliver a therapeutic agent, e.g., a small molecule, peptide or other drug, to a cell or tissue to be treated.

Abstract: The present invention relates to improved therapeutically active nanocomposite microstructure compositions, including nanoparticle compositions and nanoparticle preparations. Preferred embodiments include nanoparticle compositions comprising nanoparticles of a therapeutically active agent dispersed in a carrier matrix. The invention also relates to a method for preparing said compositions and preparations using solid-state mechanochemical synthesis. Further, it relates to therapeutic products produced using said compositions and to methods of treatment using the compositions.

Abstract: Provided herein are engineered cells and methods for engineering cells to deliver a therapeutic agent, e.g., a small molecule, peptide or other drug, to a cell or tissue to be treated.

Abstract: A method for producing a composition comprising nanoparticles of a biologically active compound.

Abstract: The present invention relates to improved therapeutically active nanocomposite microstructure compositions, including nanoparticle compositions and nanoparticle preparations. Preferred embodiments include nanoparticle compositions comprising nanoparticles of a therapeutically active agent dispersed in a carrier matrix. The invention also relates to a method for preparing said compositions and preparations using solid-state mechanochemical synthesis. Further, it relates to therapeutic products produced using said compositions and to methods of treatment using the compositions.

Abstract: The invention provides for a process for removing thiocarbonylthio groups from polymer prepared by RAFT polymerization, the process comprising: introducing into a flow reactor a solution comprising the RAFT polymer in solvent; and promoting a reaction within the flow reactor that removes the thiocarbonylthio groups so as to form a solution that flows out of the reactor comprising the RAFT polymer absent the thiocarbonylthio groups.

Abstract: An electroluminescence device having an emission layer comprising a single organic compound layer between a cathode and an anode. The single layer may comprise an emitter component on a single polymer chain of covalently linked (co)-polymer sections Y1, optionally in combination with Y2, and/or Y3, or different polymer chains Y1, optionally in combination with Y2, and/or Y3 blended together. Each of the (co)-polymer contains a spacer unit and a carrier transporting component and optionally an emitter moiety.

Abstract: A method for producing a composition comprising nanoparticles of a biologically active compound.

Abstract: The invention provides for a process for removing thiocarbonylthio groups from polymer prepared by RAFT polymerisation, the process comprising: introducing into a flow reactor a solution comprising the RAFT polymer in solvent; and promoting a reaction within the flow reactor that removes the thiocarbonylthio groups so as to form a solution that flows out of the reactor comprising the RAFT polymer absent the thiocarbonylthio groups.

Abstract: A method for producing a composition comprising nanoparticles of a biologically active compound, comprising the step of: dry milling a solid biologically active compound and a millable grinding compound in a mill comprising a plurality of milling bodies, for a time period sufficient to produce a solid dispersion comprising nanoparticles of the biologically active compound dispersed in an at least partially milled grinding compound is described as are various compositions produced using such methods.

Abstract: An electroluminescence device having an emission layer comprising a single organic compound layer between a cathode and an anode. The single layer may comprise an emitter component on a single polymer chain of covalently linked (co)-polymer sections Y1, optionally in combination with Y2, and/or Y3, or different polymer chains Y1, optionally in combination with Y2, and/or Y3 blended together. Each of the (co)-polymer contains a spacer unit and a carrier transporting component and optionally an emitter moiety.

Abstract: The present invention relates to an organic electroluminescent device comprising a pair of electrodes forming an anode and cathode, and one or more layers of organic compound arranged between the pair of electrodes, wherein the organic compound layer comprises heptaazaphenalene derivatives of formula (1). The present invention also relates to the said compounds.

Abstract: The invention provides a process for increasing the melt flow index of a polyolefin, the process comprising using a melt mixing device to melt mix the polyolefin in contact with oxygen and a transition metal catalyst having a redox potential ranging from 0 to 2 volts, wherein oxygen is introduced to the melt mixing device, and wherein the transition metal catalyst in contact with the polyolefin forms at least part of a component of the melt mixing device.

Abstract: The present invention relates to improved therapeutically active nanocomposite microstructure compositions, including nanoparticle compositions and nanoparticle preparations. Preferred embodiments include nanoparticle compositions comprising nanoparticles of a therapeutically active agent dispersed in a carrier matrix. The invention also relates to a method for preparing said compositions and preparations using solid-state mechanochemical synthesis. Further, it relates to therapeutic products produced using said compositions and to methods of treatment using the compositions.