Patents by Inventor Alois Jungbauer
Alois Jungbauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150225473Abstract: This disclosure relates to methods for isolating antibodies from cell-free culture supernatant.Type: ApplicationFiled: August 27, 2013Publication date: August 13, 2015Inventors: Alois JUNGBAUER, Peter SATZER, Anne-Luise TSCHELIESSNIG
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Patent number: 8372959Abstract: Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprises the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically inactive form by an affinity chromatography system, b) refolding of the fusion polypeptide, thereby activating the autoproteolytic function of the fusion polypeptide and causing cleavage of the heterologous polypeptide of interest, and c) subsequently eluting the heterologous polypeptide of interest, wherein the steps are conducted on one affinity chromatography system.Type: GrantFiled: January 11, 2012Date of Patent: February 12, 2013Assignees: Sandoz AG, Boehringer Ingelheim RCV GmbH & Co KGInventors: Alois Jungbauer, Rainer Hahn, Anne Tscheliessnig, Waltraud Kaar
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Publication number: 20120107869Abstract: Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprising the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically inactive form by an affinity chromatography system, b) refolding of the fusion polypeptide, thereby activating the autoproteolytic function of the fusion polypeptide and causing cleavage of the heterologous polypeptide of interest, and c) subsequently eluting the heterologous polypeptide of interest, wherein said steps are conducted on one affinity chromatography system.Type: ApplicationFiled: January 11, 2012Publication date: May 3, 2012Applicants: BOEHRINGER INGELHEIM RCV GmbH & Co KG, SANDOZ AGInventors: Alois JUNGBAUER, Rainer Hahn, Anne Tscheliessnig, Waltraud Karr
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Patent number: 8163890Abstract: Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprising the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically inactive form by an affinity chromatography system, b) refolding of the fusion polypeptide, thereby activating the autoproteolytic function of the fusion polypeptide and causing cleavage of the heterologous polypeptide of interest, and c) subsequently eluting the heterologous polypeptide of interest, wherein said steps are conducted on one affinity chromatography system.Type: GrantFiled: April 25, 2006Date of Patent: April 24, 2012Assignees: Sandoz AG, Boehringer Ingelheim RCV GmbH & Co KGInventors: Alois Jungbauer, Rainer Hahn, Anne Tscheliessnig, Waltraud Kaar
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Patent number: 8058410Abstract: Disclosed is an affinity matrix comprising a solid phase and an affinity ligand comprising peptide bonds coupled to this solid phase, wherein the affinity ligand comprising peptide bond is selected from the following group of ligands: a) peptides comprising the formula X1X2X3X4, wherein X1 to X4 are amino acid residues and at least two of X1 to X4 is W, Y or F; b) peptides comprising the formula X5X6X7X8, wherein X5 to X8 are amino acid residues, at least one of X5 to X8 is W, and at least one of X5 to X8 is E or D; and c) poly-amino acids consisting of an amino acid monomer of the group consisting of R, K, E and D and an amino acid monomer of the group consisting of Y, F and W, preferably poly-KY, poly-KF, poly-KW, poly-RY, poly-RF, poly-RW, poly-EY, poly-DY, poly-EF, poly-EW, poly-DF and poly-DW, with the proviso that the peptides according to a) and b) have a maximum length of 35 amino acid residues and that the poly-amino acids according to c) have a minimum length of 20 amino acid residues.Type: GrantFiled: April 25, 2006Date of Patent: November 15, 2011Assignees: Sandoz AG, Boehringer Ingelheim RCV GmbH & Co KGInventors: Alois Jungbauer, Rainer Hahn, Waltraud Kaar, Michael Seifert, Bernhard Auer, Clemens Achmüller, Philipp Wechner
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Publication number: 20100055125Abstract: The present invention relates to a vector library comprising a multiplicity of different eukaryotic secretion vectors, wherein each vector comprises under the control of transcriptional and translational control sequences a gene encoding for an extracellular soluble fusion polypeptide which gene comprises a coding sequence for a scaffold polypeptide linked to variable coding sequences for a peptide, wherein said vectors comprise a nucleic acid coding for a secretory signal sequence linked to the gene coding for the fusion polypeptide.Type: ApplicationFiled: March 29, 2007Publication date: March 4, 2010Applicant: UNIVERSITAT FUR BODENKULTUR WIENInventors: Alois Jungbauer, Christa Mersich
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Publication number: 20090306343Abstract: Disclosed is an affinity matrix comprising a solid phase and an affinity ligand comprising peptide bonds coupled to this solid phase, wherein the affinity ligand comprising peptide bond is selected from the following group of ligands: a) peptides comprising the formula X1X2X3X4, wherein X1 to X4 are amino acid residues and at least two of X1 to X4 is W, Y or F; b) peptides comprising the formula X5X6X7X8, wherein X5 to X8 are amino acid residues, at least one of X5 to X8 is W, and at least one of X5 to X8 is E or D; and c) poly-amino acids consisting of an amino acid monomer of the group consisting of R, K, E and D and an amino acid monomer of the group consisting of Y, F and W, preferably poly-KY, poly-KF, poly-KW, poly-RY, poly-RF, poly-RW, poly-EY, poly-DY, poly-EF, poly-EW, poly-DF and poly-DW, with the proviso that the peptides according to a) and b) have a maximum length of 35 amino acid residues and that the poly-amino acids according to c) have a minimum length of 20 amino acid residues.Type: ApplicationFiled: April 25, 2006Publication date: December 10, 2009Inventors: Alois Jungbauer, Rainer Hahn, Waltraud Kaar, Michael Seifert, Bernhard Auer, Clemens Achmuller, Philipp Wechner
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Publication number: 20090203069Abstract: Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprising the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically inactive form by an affinity chromatography system, b) refolding of the fusion polypeptide, thereby activating the autoproteolytic function of the fusion polypeptide and causing cleavage of the heterologous polypeptide of interest, and c) subsequently eluting the heterologous polypeptide of interest, wherein said steps are conducted on one affinity chromatography system.Type: ApplicationFiled: April 25, 2006Publication date: August 13, 2009Applicants: BOEHRINGER INGELHEIM AUSTRIA GMBH, SANDOZ AGInventors: Alois Jungbauer, Rainer Hahn, Anne Tscheliessnig, Waltraud Kaar
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Publication number: 20090182028Abstract: The present invention provides a medicament comprising a chemical compound according to formula A: wherein R1 is hydrogen, fluorine, chlorine, bromine, hydroxy, mercapto, methoxy, ethoxy, acetoxy, methyl, ethyl, propyl, isopropyl, t-butyl, nitro, amin, N,N-dimethylaminoyl, N,N-diethyl-aminoyl; R2 is hydrogen, a C1-8-alkyl e.g. methyl, ethyl, propyl, isopropyl, butyl, t-butyl; an C1-8-acyl e.g. acetyl, propionyl; R3 is a C5-12-heterocyclic ring, e.g. furanyl, pyranyl, pyrrolyl, pyridinyl, pyrazolyl, thienyl, thiazolyl, indolyl or -0R4 ; R4 is a C5-C12-aromatic ring e.g. phenyl; unsubstituted or substituted in any position with fluorine, chlorine, bromine, methoxy, ethoxy, C1-8-carboxy; Z is OH or 0; and n is 0, 1, 2 or 3, and m is 0, 1, 2 or 3, and its use for the activation of the aryl hydro carbon receptor.Type: ApplicationFiled: March 29, 2007Publication date: July 16, 2009Applicant: G.I.M. GESELLSCHAFT-FUR INNOVATIVE MEDIZIN G.M.B.H NFG OHGInventors: Alois Jungbauer, Svjetlana Medjakovic, Alfred Zöchling
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Publication number: 20080131534Abstract: The present invention provides methods for increasing peroxisome proliferator-activated receptor-gamma (PPAR?) activity and/or endothelial nitric oxide synthase (eNOS) activity in a subject by administering to the subject a plant extract or plant juice from thyme, oregano, clove, nutmeg, red clover, bay leaves, red onion or grapes.Type: ApplicationFiled: November 15, 2007Publication date: June 5, 2008Applicant: Melbrosin International Produktions- und Vertriebs GesmbH & Co KGInventors: Alois JUNGBAUER, Monika MULLER
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Publication number: 20070243201Abstract: The invention relates to a method for the selection of epitopes for immunotherapy, peptides obtained by said method, the use of said peptides as vaccines and diagnostics and an immune serum obtainable by said method.Type: ApplicationFiled: June 2, 2004Publication date: October 18, 2007Applicant: Igeneon Krebs-Immuntherapie Forschungs-und entwicklungs-AGInventors: Hans Loibner, Gottfried Himmler, Alois Jungbauer, Erich Wasserbauer, Manfred Schuster, Rainer Hahn, Astrid Durauer
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Patent number: 7060460Abstract: In a method for reconstituting a recombinant protein from a denatured state to its active form, a feed solution containing the recombinant protein in its denatured and/or in biologically inactive intermediate forms is subjected to a chromatographic separation process, in which the protein is reconstituted under conditions that promote refolding of the protein and the intermediate forms are separated from the refolded protein. The denatured form and/or the inactive intermediate forms of the protein are separated from the refolded protein in a continuous or quasi-continuous manner and optionally recycled to the feed solution.Type: GrantFiled: October 2, 2002Date of Patent: June 13, 2006Assignee: Boehringer Ingelheim Austria GmbHInventors: Roman Necina, Robert Schlegl, Alois Jungbauer, Christine Machold
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Patent number: 6664305Abstract: A process of manufacturing of a chromatography material comprising the steps of (i) reacting a polymerizable at least bifunctional monomer A with a ligand also having a functional group which binds covalently with one of the functional groups of said polymerizable bifunctional monomer A, (ii) to form a compound B comprising at least one polymerizable functional moiety (iii) polymerizing the compound B essentially alone or with the polymerizable monomers in presence of porogenes to obtain a block of porous polymerizate which is self-supporting or (iv) reacting the ligand and a spacer via a covalent bond which is cleavable to form a ligand-spacer conjugate and binding the ligand-spacer conjugate to the surface of a chromatographic support or reacting the ligand-spacer conjugate via a covalent bond to the at least bi-functional monomer A and polymerizing it essentially alone or with the polymerizable monomers in presence of porogenes to obtain a block of porous polymerizate which is self-supporting.Type: GrantFiled: October 28, 2002Date of Patent: December 16, 2003Assignee: BIA Separations d.o.o.Inventors: Alois Jungbauer, Rainer Hahn, Ales Podgornik, Milos Barut, Ales Strancar
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Publication number: 20030125204Abstract: A process of manufacturing of a chromatography material comprising the steps ofType: ApplicationFiled: October 28, 2002Publication date: July 3, 2003Inventors: Alois Jungbauer, Rainer Hahn, Ales Podgornik, Milos Barut, Ales Strancar
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Publication number: 20030113866Abstract: In a method for reconstituting a recombinant protein from a denatured state to its active form, a feed solution containing the recombinant protein in its denatured and/or in biologically inactive intermediate forms is subjected to a chromatographic separation process, in which the protein is reconstituted under conditions that promote refolding of the protein and the intermediate forms are separated from the refolded protein. The denatured form and/or the inactive intermediate forms of the protein are separated from the refolded protein in a continuous or quasi-continuous manner and optionally recycled to the feed solution.Type: ApplicationFiled: October 2, 2002Publication date: June 19, 2003Inventors: Roman Necina, Robert Schlegl, Alois Jungbauer, Christine Machold
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Patent number: 5831034Abstract: Novel human monoclonal anti-HIV-I antibodies and immunochemicals made from the antibodies and method of treating or preventing HIV-I infections.Type: GrantFiled: August 22, 1994Date of Patent: November 3, 1998Assignee: Hermann KatingerInventors: Hermann Katinger, Alois Jungbauer, Franz Steindl, Andrea Buchacher
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Patent number: 5753503Abstract: The invention is directed to human monoclonal antibodies specific for the gp41 envelope protein of human immunodeficiency virus type 1 (HIV-1). Specifically disclosed are the human monoclonal antibodies produced by the cell lines 3D6 having ECACC Accession No. 87110301, 24G3 having ECACC Accession No. 90091702 and 25C2 having ECACC Accession No. 80120601.Type: GrantFiled: December 1, 1994Date of Patent: May 19, 1998Assignee: Hermann W. D. KatingerInventors: Hermann W. D. Katinger, Ruediger von Baehr, Alois A. Jungbauer, Tomas Porstmann, Franz J. Steindl, Roland Grunow
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Patent number: 5676837Abstract: A method for sterilizing liquid chromatography resins that are highly resistant to oxidation by strongly oxidizing agents and a sterilization solution for use therein. In a preferred embodiment, the invention comprises contacting an oxidant-resistant chromatographic resin with an aqueous solution of peracetic acid and up to 40% ethanol. In particular, where the solution is to be used to sterilize a positively charged ion-exchange resin, the solution preferably additionally includes an acetate buffer of a sufficient ionic strength to prevent adsorption of the peracetic acid ions on the resin.Type: GrantFiled: June 7, 1996Date of Patent: October 14, 1997Assignee: BioSepra, Inc.Inventors: Alois Jungbauer, Hans Peter Lettner
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Patent number: 5423982Abstract: A liquid chromatography column well-suited for in situ sterilization effected by washing with a sterilization solution. In a preferred embodiment, the column comprises a liquid chromatography tube packed with a liquid chromatography resin. A piston assembly is mounted within the liquid chromatography tube towards the upper end thereof, the piston assembly including an upper portion and a lower portion, the lower portion being shaped to include a fluid distribution channel and a downwardly-extending collar, the downwardly-extending collar including an annular slot and defining an orifice in fluid communication with the fluid distribution channel.Type: GrantFiled: May 31, 1994Date of Patent: June 13, 1995Assignee: BioSepra Inc.Inventors: Alois Jungbauer, Hans P. Lettner