Patents by Inventor Alptekin Aksan

Alptekin Aksan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11968975
    Abstract: A lyoprotectant composition includes one or more lyoprotective carbohydrates comprising a non-reducing polysaccharide. The non-reducing polysaccharide may be dextranol. The one or more lyoprotective carbohydrates may include a non-reducing disaccharide. The lyoprotectant composition may be free of or substantially free of reducing sugars. The composition may be in the form of a matrix including a non-woven web of fibers having an average diameter of 0.1 ?m to 2.5 ?m. A method of storing a liquid biospecimen includes mixing the liquid biospecimen with the lyoprotectant composition to prepare a specimen-loaded composition; drying the specimen-loaded composition; and storing the dried specimen-loaded composition.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: April 30, 2024
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Bryan Jones, Alptekin Aksan, Advitiya Mahajan
  • Patent number: 10905113
    Abstract: This disclosure describes a lyoprotectant matrix, compositions including the lyoprotectant matrix and methods for storing a liquid biospecimen using the lyoprotectant matrix. Generally, the lyoprotectant matrix includes a non-woven web having fibers having, as components, at least one lyoprotective carbohydrate and at least one polymer. The matrix further possesses an apparent pore size of 0.1 ?m to 500 ?m.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: February 2, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Alptekin Aksan, Morwena Jane V. Solivio, Marcus Kramer, Rebekah Less
  • Publication number: 20200370033
    Abstract: According to various embodiments of the present disclosure, a biological assembly for performing biocatalysis includes a biological component. The assembly further includes a porous shell layer at least partially coating the biological component. The porous shell layer includes an inorganic network having a cationic component and an anionic component.
    Type: Application
    Filed: December 31, 2018
    Publication date: November 26, 2020
    Inventors: Jonathan Konstantine Sakkos, Alptekin Aksan, Lawrence P. Wackett
  • Publication number: 20200345000
    Abstract: A lyoprotectant composition includes one or more lyoprotective carbohydrates comprising a non-reducing polysaccharide. The non-reducing polysaccharide may be dextranol. The one or more lyoprotective carbohydrates may include a non-reducing disaccharide. The lyoprotectant composition may be free of or substantially free of reducing sugars. The composition may be in the form of a matrix including a non-woven web of fibers having an average diameter of 0.1 ?m to 2.5 ?m. A method of storing a liquid biospecimen includes mixing the liquid biospecimen with the lyoprotectant composition to prepare a specimen-loaded composition; drying the specimen-loaded composition; and storing the dried specimen-loaded composition.
    Type: Application
    Filed: April 28, 2020
    Publication date: November 5, 2020
    Inventors: Bryan Jones, Alptekin Aksan, Advitiya Mahajan
  • Patent number: 10035719
    Abstract: Systems and methods for producing and extracting a gas from a wastewater fluid including multiple sheets or layers that form a composite membrane. The composite membrane includes a sandwich structure in which a dry matrix layer is surrounded by a first layer including a first immobilized bacteria and a second layer including a second immobilized bacteria. The first immobilized bacteria and the second immobilized bacteria can be configured to produce a gas from one or more compounds in a wastewater fluid. The dry matrix layer can be configured to receive the gas from the first and second layers, and the gas can be extracted from the membrane. The hydrophobic coatings can be disposed between the dry matrix layer and one or both of the first and second layers. An adhesive interface can be disposed between the dry matrix layer and one or both of the first and second layers.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: July 31, 2018
    Assignee: Regents of the University of Minnesota
    Inventors: Paige J. Novak, William Alan Arnold, Alptekin Aksan
  • Patent number: 9790484
    Abstract: The present invention relates to compositions for encapsulation of biomaterials in a silica-matrix. The present invention includes a composition for formation of a silica-matrix encapsulated biomaterial. The composition includes a reactive silicon compound and a biomaterial with a catalytic activity. When encapsulated in the silica-matrix, the biomaterial at least partially retains its catalytic activity. The present invention also relates to methods of making silica-matrix encapsulated biomaterials, and to methods of using silica-matrix encapsulated biomaterials, including methods of treating water or gas using the silica-matrix encapsulated biomaterials.
    Type: Grant
    Filed: February 22, 2012
    Date of Patent: October 17, 2017
    Assignee: Regents of the University of Minnesota
    Inventors: Lawrence P. Wackett, Alptekin Aksan, Michael J Sadowsky, Eduardo Reategui, Lisa Kasinkas
  • Publication number: 20170135333
    Abstract: This disclosure describes a lyoprotectant matrix, compositions including the lyoprotectant matrix and methods for storing a liquid biospecimen using the lyoprotectant matrix. Generally, the lyoprotectant matrix includes a non-woven web having fibers having, as components, at least one lyoprotective carbohydrate and at least one polymer. The matrix further possesses an apparent pore size of 0.1 ?m to 500 ?m.
    Type: Application
    Filed: November 11, 2016
    Publication date: May 18, 2017
    Inventors: Alptekin Aksan, Morwena Jane V. Solivio, Marcus Kramer, Rebekah Less
  • Publication number: 20170087274
    Abstract: Disclosed herein are synthetic silica-based ocular devices fabricated from a composite material comprising silica and a fibrillar protein, together with methods of making and using the ocular devices.
    Type: Application
    Filed: October 6, 2016
    Publication date: March 30, 2017
    Inventors: Alptekin Aksan, Allison Hubel, Eduardo Reategui
  • Patent number: 9492271
    Abstract: Disclosed herein are synthetic silica-based ocular devices fabricated from a composite material comprising silica and a fibrillar protein, together with methods of making and using the ocular devices.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: November 15, 2016
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Alptekin Aksan, Allison Hubel, Eduardo Reategui
  • Patent number: 9427408
    Abstract: The present invention provides compositions for encapsulation of biomaterials in a silica-matrix. The present invention also provides methods of making silica-matrix encapsulated biomaterials, and to methods of using silica-matrix encapsulated biomaterials. In one embodiment, the present invention provides a method of encapsulating mammalian cells in a silica-matrix while maintaining metabolic activity. In another embodiment, the present invention provides a method of purifying cancer cells using a silica-matrix.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: August 30, 2016
    Inventors: Eduardo Reategui, Lisa Kasinkas, Alptekin Aksan
  • Publication number: 20160175634
    Abstract: A composition or article that includes a first silica-matrix encapsulated biomaterial, the first silica-matrix encapsulated biomaterial including a first silica matrix and a first biomaterial; and a second silica-matrix encapsulated biomaterial, the second silica-matrix encapsulated biomaterial including a second silica matrix and a second biomaterial, wherein the first silica-matrix encapsulated biomaterial has at least one property that is different than that of the second silica-matrix encapsulated biomaterial, and wherein the first silica-matrix encapsulated biomaterial forms a first layer and the second silica-matrix encapsulated biomaterial forms a second layer, and the first layer is positioned adjacent the second layer.
    Type: Application
    Filed: October 14, 2015
    Publication date: June 23, 2016
    Inventors: Adi Ish Am Radian, Jonathan Konstantine Sakkos, Baris Ragip Mutlu, Lawrence Philip Wackett, Alptekin Aksan
  • Publication number: 20160107912
    Abstract: Systems and methods for producing and extracting a gas from a wastewater fluid can include multiple sheets or layers that form a composite membrane. The composite membrane can include a sandwich structure in which a dry matrix layer is surrounded by a first layer including a first immobilized bacteria and a second layer including a second immobilized bacteria. The first immobilized bacteria and the second immobilized bacteria can be configured to produce a gas from one or more compounds in a wastewater fluid. The dry matrix layer can be configured to receive the gas from the first and second layers, and the gas can be extracted from the membrane. In an example, hydrophobic coatings can be disposed between the dry matrix layer and one or both of the first and second layers. In an example, an adhesive interface can be disposed between the dry matrix layer and one or both of the first and second layers.
    Type: Application
    Filed: October 15, 2015
    Publication date: April 21, 2016
    Inventors: Paige J. Novak, William Alan Arnold, Alptekin Aksan
  • Publication number: 20150353399
    Abstract: This disclosure describes compositions, devices, and methods relating to removal of cyanuric acid from a sample. Generally, the compositions include a cell that expresses at least one enzyme that degrades cyanuric acid and a matrix material that covers at least a portion of the cell. Generally, the methods include contacting the sample with the composition, or a device that includes the composition, and allowing the enzyme of the composition to degrade cyanuric acid in the sample.
    Type: Application
    Filed: June 10, 2015
    Publication date: December 10, 2015
    Inventors: Lawrence Philip Wackett, Alptekin Aksan, Baris Ragip Mutlu, Sujin Yeom, Adi Ish Am Radian, Kelly Aukema
  • Publication number: 20140335148
    Abstract: An ultrafine fiber comprises a ceramic-based fibrous body and a biologically active substance encapsulated in the body, substantially encapsulated in the body, or surface-attached to the body. In an example, an ultrafine fiber comprises a core comprising a biologically active substance and a ceramic-based shell surrounding or substantially surrounding the core.
    Type: Application
    Filed: May 7, 2014
    Publication date: November 13, 2014
    Inventors: Ho-Wang Tong, Lawrence P. Wackett, Alptekin Aksan
  • Publication number: 20140302130
    Abstract: The present invention provides compositions for encapsulation of biomaterials in a silica-matrix. The present invention also provides methods of making silica-matrix encapsulated biomaterials, and to methods of using silica-matrix encapsulated biomaterials. In one embodiment, the present invention provides a method of encapsulating mammalian cells in a silica-matrix while maintaining metabolic activity. In another embodiment, the present invention provides a method of purifying cancer cells using a silica-matrix.
    Type: Application
    Filed: November 7, 2012
    Publication date: October 9, 2014
    Inventors: Eduardo Reategui, Lisa Kasinkas, Alptekin Aksan
  • Publication number: 20140051144
    Abstract: The present invention relates to compositions for encapsulation of biomaterials in a silica-matrix. The present invention includes a composition for formation of a silica-matrix encapsulated biomaterial. The composition includes a reactive silicon compound and a biomaterial with a catalytic activity. When encapsulated in the silica-matrix, the biomaterial at least partially retains its catalytic activity. The present invention also relates to methods of making silica-matrix encapsulated biomaterials, and to methods of using silica-matrix encapsulated biomaterials, including methods of treating water or gas using the silica-matrix encapsulated biomaterials.
    Type: Application
    Filed: February 22, 2012
    Publication date: February 20, 2014
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Lawrence P. Wackett, Alptekin Aksan, Michael J Sadowsky, Eduardo Reategui, Lisa Kasinkas
  • Publication number: 20130204363
    Abstract: Disclosed herein are synthetic silica-based ocular devices fabricated from a composite material comprising silica and a fibrillar protein, together with methods of making and using the ocular devices.
    Type: Application
    Filed: February 8, 2011
    Publication date: August 8, 2013
    Applicant: Regents of the University of Minnesota
    Inventors: Alptekin Aksan, Allison Hubel, Eduardo Reatágui
  • Patent number: 6375672
    Abstract: The present invention provides a method for strengthening collagen in collagenous tissue which uses the controlled application of heat to induce shrinkage or contraction of the collagen in the tissue and a cross-linking means which cross-links the shrunken collagen in the tissue thereby stabilizing and strengthening collagenous tissue. In particular, the present invention provides an in vivo method for treating joint instability problems, controlled manipulation of skin structure and properties, and other problems involving collagen-containing tissues. The present invention further provides an in vitro method for stabilizing collagenous tissue for use in vivo or in vitro. Further, the present invention provides a method for treating collagenous tissue and testing the strength and stability of the treated tissue.
    Type: Grant
    Filed: March 21, 2000
    Date of Patent: April 23, 2002
    Assignee: Board of Trustees of Michigan State University
    Inventors: Alptekin Aksan, John J. McGrath