Patents by Inventor Amalia Cipollone

Amalia Cipollone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of nebivolol
    Patent number: 9090922
    Abstract: The present invention relates to a novel process for the synthesis of the Nebivolol product depicted in Scheme 1, comprised of a reduced number of high-yield steps, and characterized by the enzymatic resolution of the chroman ester precursor.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: July 28, 2015
    Assignee: MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A.
    Inventors: Sandro Mauro, Daniela Fattori, Piero D'Andrea, Amalia Cipollone, Enzo D'Andrea, Carmela Ercolano
  • Process for the preparation of nebivolol
    Patent number: 8785664
    Abstract: The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: July 22, 2014
    Assignee: Menarini International Operations Luxembourg S.A.
    Inventors: Sandra Bartoli, Amalia Cipollone, Daniela Fattori
  • PROCESS FOR THE PREPARATION OF NEBIVOLOL
    Publication number: 20130295622
    Abstract: The present invention relates to a novel process for the synthesis of the Nebivolol product depicted in Scheme 1, comprised of a reduced number of high-yield steps, and characterized by the enzymatic resolution of the chroman ester precursor.
    Type: Application
    Filed: November 30, 2011
    Publication date: November 7, 2013
    Applicant: MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A.
    Inventors: Sandro Mauro, Daniela Fattori, Amalia Cipollone
  • PROCESS FOR THE PREPARATION OF NEBIVOLOL
    Publication number: 20130274486
    Abstract: The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations.
    Type: Application
    Filed: May 31, 2013
    Publication date: October 17, 2013
    Inventors: Sandra BARTOLI, Amalia Cipollone, Daniela Fattori
  • Process for the preparation of nebivolol
    Patent number: 8487122
    Abstract: The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: July 16, 2013
    Assignee: Menarini International Operations Luxembourg S.A.
    Inventors: Sandra Bartoli, Amalia Cipollone, Daniela Fattori
  • PROCESS FOR THE PREPARATION OF NEBIVOLOL
    Publication number: 20120316351
    Abstract: The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations.
    Type: Application
    Filed: February 9, 2011
    Publication date: December 13, 2012
    Inventors: Sandra Bartoli, Amalia Cipollone, Daniela Fattori
  • L-arabino-disaccharides of anthracyclines, processes for their preparation, and pharmaceutical compositions containing them
    Patent number: 6653289
    Abstract: The present invention refers to compounds of general formula (I), the pharmaceutically acceptable salts thereof, the processes for their preparation, and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: November 25, 2003
    Assignee: Menarini Ricerche S.p.A.
    Inventors: Fabio Animati, Marco Berettoni, Mario Bigioni, Amalia Cipollone, Carlo Alberto Maggi
  • Antracycline disaccharides, process for their preparation, and pharmaceutical compositions containing them
    Patent number: 5801152
    Abstract: The present invention is referred to compounds of general formula (I) and (II), respectively ##STR1## their pharmaceutically acceptable salts, the process for their preparation, and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: March 28, 1996
    Date of Patent: September 1, 1998
    Assignees: A. Menarini Industrie Farmaceutiche Riunite S.r.l., Bristol-Myers Squibb S.p.A.
    Inventors: Fabio Animati, Paolo Lombardi, Frederico Arcamone, Amalia Cipollone