Abstract: The present disclosure addresses above-mentioned issues by providing a system and method for preparing a correlation data set to be used in parametric grading of malignant tissues. Systems and methods of the present disclosure further provide for a visualization scheme, wherein all the parameters can be viewed at the same time and processed together to arrive at an accurate grading of the tissue based on threshold based comparison of the parameter values for each voxel.

Abstract: The present disclosure addresses above-mentioned issues by providing a system and method for preparing a correlation data set to be used in parametric grading of malignant tissues. Systems and methods of the present disclosure further provide for a visualization scheme, wherein all the parameters can be viewed at the same time and processed together to arrive at an accurate grading of the tissue based on threshold based comparison of the parameter values for each voxel.

Abstract: The present invention relates to a method of dynamic contrast magnetic resonance imaging aimed to improve characterization of tissue image by improving accuracy of computed pharmacokinetic parameters such as Ktrans (transfer constant across capillary membrane; a pharmacokinetic parameter of tissue perfusion) using T1W Fast DCE-MRI technique to distinguish between malignant, benign and normal tissues. A phantom and a contrast agent are used in the proposed MRI system for computing accurate T1 value of a tissue after the contrast is injected based on an intrinsic T10 value the tissue, wherein the intrinsic T10 value is adjusted and/or normalized to improve accuracy of the T1 value computed, which in turn is used for computation of pharmacokinetic parameters at least one of Ktrans.

Abstract: The present invention relates to a method of dynamic contrast magnetic resonance imaging aimed to improve characterization of tissue image by improving accuracy of computed pharmacokinetic parameters such as Ktrans (transfer constant across capillary membrane; a pharmacokinetic parameter of tissue perfusion) using T1W Fast DCE-MRI technique to distinguish between malignant, benign and normal tissues. A phantom and a contrast agent are used in the proposed MRI system for computing accurate T1 value of a tissue after the contrast is injected based on an intrinsic T10 value the tissue, wherein the intrinsic T10 value is adjusted and/or normalized to improve accuracy of the T1 value computed, which in turn is used for computation of pharmacokinetic parameters at least one of Ktrans.