Abstract: The present disclosure is drawn to compositions and methods of making and using lyophilized platelet lysates. Specifically, a method of preparing a composition suitable for therapeutic use or as a culture medium can comprise steps of concentrating platelets from a platelet source to form a platelet rich portion of the platelet source, and lysing the platelets in the platelet rich portion to form a plurality of lysates. An additional step includes lyophilizing the lysates to form lyophilized platelet lysates in a composition with released concentrations of available growth factors, cytokines, and chemokines. In one example, at 30%, by platelet count, of platelets from a platelet source can be lysed using this process.

Abstract: A bone screw implant is provided for immobilizing the articular surfaces of two bone segments by securing, fusing, or compression the two segments. The implant may be fabricated from a porous biocompatible metal and have a cylindrical shape and fully or partially threaded and may have variable pitch threads and a variable diameter of the shaft. The implant may include a blunt tip or a fluted self-drilling tip and a headless screwdriver socket. Large pitch cancellous threads may be in the leading-end portion of the cylinder shaft, and smaller pitch cortical threads may be at the trailing edge portion of the shaft. The implant may be fenestrated, it may have a roughened surface, and it may be coated with an osteoconductive material. The implant may be cannulated. In a specific embodiment, the implant is used for immobilizing the articular surfaces of a sacroiliac joint.

Abstract: A patient worn sensor assembly for detecting, recording, and communicating patient vital signs includes several structural features that can provide increased signal quality, reduction in signal noise, increased patient comfort, increased reliability, and increased adhesion to a patient's skin. The patient worn sensor can track vital sign information such as blood pressure, body temperature, respiratory rate, blood oxygenation, heart rhythm (via ECG), heart rate, blood glucose level, and hydration (bio-impedance) levels. The sensor can also track and record additional information about patients, including patient movement, activity, and sleep patterns.

Abstract: Polymers comprising at least one cationic functional group and at least one ultraviolet light-absorbing compound are disclosed herein. The polymers exhibit ultraviolet light-absorbing properties and may be used in sunscreen compositions for skin and/or hair.

Abstract: A bone screw implant is provided for immobilizing the articular surfaces of two bone segments by securing, fusing, or compression the two segments. The implant may be fabricated from a porous biocompatible metal and have a cylindrical shape and fully or partially threaded and may have variable pitch threads and a variable diameter of the shaft. The implant may include a blunt tip or a fluted self-drilling tip and a headless screwdriver socket. Large pitch cancellous threads may be in the leading-end portion of the cylinder shaft, and smaller pitch cortical threads may be at the trailing edge portion of the shaft. The implant may be fenestrated, it may have a roughened surface, and it may be coated with an osteoconductive material. The implant may be cannulated. In a specific embodiment, the implant is used for immobilizing the articular surfaces of a sacroiliac joint.

Abstract: A technology is provided for mutations with immediate feedback. A mutation may be received at a data proxy from an application. The mutation may be sent to a data source via a data access resolver associated with the data proxy. Results of the mutation may be received from the data source. A subscription may be triggered based on receiving the results of the mutation. A message may be sent via a topic provided by the subscription by using a messaging service such that the messaging service publishes the message with the mutation to devices subscribed to the topic.

Abstract: Disclosed are method of enhancing perispinal perfusion in a patient suffering from reduced perfusion of the lower back through administration of T regulatory cells alone capable of stimulating angiogenesis directly or through enhancement of angiogenic activities of cellular therapies. Said cellular therapies possessing angiogenic activities include mesenchymal stem cells, hematopoietic stem cells and endothelial progenitor cells. In one embodiment of the invention, administration of T regulatory cells is performed that are expanded ex vivo. For certain embodiment of the invention T regulatory cells may be autologous or allogeneic.

Abstract: The shim-type implant for distraction and fusion of cervical facet joints is provided. The implant has a generally box-like shape with a blunt leading edge that may be centered or offset to the inferior face. The implant may include a graft window for enhanced osseous through-growth after implantation. The implant is coated with hydroxyapatite (HA) and/or tri-calcium phosphate (TCP) to allow for osteo-conduction, is porous, and has a roughened surface with serrations on the superior and inferior faces. The implant may be fabricated from a titanium or tantalum alloy. In an embodiment, a set of tools is provided with a chisel and one or tongs and one or more decorticators for inserting the implant.

Abstract: Polymers comprising at least one cationic functional group and at least one ultraviolet light-absorbing compound are disclosed herein. The resulting polymers exhibit ultraviolet light-absorbing properties and may be used in sunscreen compositions for skin and/or hair.

Abstract: This invention pertains to the field of ovarian aging and premature ovarian failure. Specifically, we herein disclose methods for treating these conditions using endothelial progenitor cells alone or in combination with mesenchymal stem cells. Furthermore, these cell-based therapies can be utilized in combination with estrogen and progesterone receptor ligands to enhance the therapeutic activity of said cells for restoring or maintaining ovarian function and female fertility.

Abstract: Disclosed are methods useful for the treatment of erectile dysfunction through stimulation of regenerative activities in a patient in need of treatment. In one embodiment, the invention provides the administration of extracorporeal shock waves prior to administration of regenerative cells in order to enhance the penile microenvironment in a manner favorable for augmented regenerative activity. In some embodiments said regenerative cells comprise of autologous bone marrow cells. In other embodiments regenerative cells are allogeneic cells. The invention further teaches the use of regenerative cell mobilization combined with administration of extracorporeal shock wave therapy.

Abstract: Disclosed is a foam booster that is capable of producing or increasing the amount of foam in any given composition. The foam booster includes a saccharide blend having 30 wt. % to 50 wt. % of an aldohexose or mixture of aldohexoses, 20 wt. % to 55 wt. % of a ketohexose or mixture of ketohexoses; and 10 wt. % to 20 wt. % of a disaccharide or mixture of disaccharides.

Abstract: Streamlined and integrated patient care and health information management systems and methods for reducing the need for costly, near constant patient monitoring by providing system components that allow healthcare professionals to view the most important data for a number of patients in varying physical locations in a seamless manner are disclosed. Various components of the system can be used to monitor patients; measure, record, and track vital signs; and coordinate patient care in an automated fashion. Patients that have a achieved a relatively stable condition during a recovery process, but who still require or would benefit from near constant, or frequent vital sign monitoring can be provided with one or more body worn vital sign sensors. These patient worn sensors can track vital sign and other information about patients, including patient movement, activity, and sleep patterns.

Abstract: Streamlined and integrated patient care and health information management systems and methods for reducing the need for costly, near constant patient monitoring by providing system components that allow healthcare professionals to view the most important data for a number of patients in varying physical locations in a seamless manner are disclosed. Various components of the system can be used to monitor patients; measure, record, and track vital signs; and coordinate patient care in an automated fashion. Patients that have a achieved a relatively stable condition during a recovery process, but who still require or would benefit from near constant, or frequent vital sign monitoring can be provided with one or more body worn vital sign sensors. These patient worn sensors can track vital sign and other information about patients, including patient movement, activity, and sleep patterns.

Abstract: A system (100) includes an echocardiogram measurement tool (150) that determines a subset (152) of measurements from a list of echocardiogram measurements according to a view of an ultrasound imaging sequence (110) and a mapping (154) between the view and the subset of measurements.

Abstract: Disclosed is a foam booster that is capable of producing or increasing the amount of foam in any given composition. The foam booster includes a saccharide blend having 30 wt. % to 50 wt. % of an aldohexose or mixture of aldohexoses, 20 wt. % to 55 wt. % of a ketohexose or mixture of ketohexoses; and 10 wt. % to 20 wt. % of a disaccharide or mixture of disaccharides.

Abstract: A method of operation of a navigation system includes: determining a surrounding condition with a control unit for selecting an input source to capture a surrounding object; determining an operating context based on calculating an average stopped time meeting or exceeding a time threshold within the surrounding condition; determining a feature availability based on the operating context for restricting a device feature available on a device; and delivering an alert notification based on an object count below a count threshold for presenting on the device.

Abstract: A vertebral disc including a superior surface layer, an inferior surface layer, a midsection between the superior and inferior surface layers and a hollow center. The superior surface layer and inferior surface layer each comprise a layer of lattice with pore sizes in the range of 200-900 ?m and a porosity of each layer of 55-75%. The midsection of the implant comprises a random or pseudorandom lattice interposed between the superior surface layer and inferior surface layer with larger, macro-pores of various sizes. There is a gradient of pore sizes along a longitudinal axis with the smallest pore sizes comprising the superior and inferior surfaces and the largest pore sizes comprising the midsection.

Abstract: A patient worn sensor assembly for detecting, recording, and communicating patient vital signs includes several structural features that can provide increased signal quality, reduction in signal noise, increased patient comfort, increased reliability, and increased adhesion to a patient's skin. The patient worn sensor can track vital sign information such as blood pressure, body temperature, respiratory rate, blood oxygenation, heart rhythm (via ECG), heart rate, blood glucose level, and hydration (bio-impedance) levels. The sensor can also track and record additional information about patients, including patient movement, activity, and sleep patterns.

Abstract: Various cells, stem cells, and stem cell components, including associated methods of generating and using such cells are provided. In one aspect, for example, an isolated cell that is capable of self-renewal and culture expansion and is obtained from a subepithelial layer of a mammalian umbilical cord tissue. Such an isolated cell expresses at least three cell markers selected from CD29, CD73, CD90, CD166, SSEA4, CD9, CD44, CD146, or CD105, and does not express at least three cell markers selected from CD45, CD34, CD14, CD79, CD106, CD86, CD80, CD19, CD117, Stro-1, or HLA-DR.