Abstract: Systems and methods are provided for managing a construction project using a digital twin or digital execution verification. A data ingestion module receives construction project data from data sources through a communication interface. An infrastructure module generates a digital twin of the construction project using a first data subset, and generates a plan model of the construction project using a second data subset. A display interface displays at least a portion of the digital twin overlaid with a corresponding portion of the plan model in a virtual environment. The plan model contains at least one planned component. The digital twin contains at least one construction component associated with a corresponding constructed component at a construction site. A construction mismatch is determined based on a comparison of the digital twin and the plan model, and is used to made adjustments for the construction project.

Abstract: The present disclosure relates to methods of producing antibodies with increased levels of non-fucosylated glycoforms by culturing mammalian cells in culture media with enhanced concentrations of glycine relative to traditional basal media.

Abstract: The present disclosure relates to methods of producing antibodies with increased levels of non-fucosylated glycoforms by culturing mammalian cells in culture media with enhanced concentrations of glycine relative to traditional basal media.