Abstract: The instant invention provides pharmaceutical formulations for a long acting injectable drug product comprising a suspension of doravirine for parenteral administration via intramuscular or subcutaneous routes. The drug product can be used for the treatment or prophylaxis of infection by HIV or for the treatment, prophylaxis, or delay in the onset of AIDS (acquired immunodeficiency syndrome) or ARC (AIDS related complex).

Abstract: The instant invention provides pharmaceutical formulations for a long acting injectable drug product comprising a suspension of doravirine for parenteral administration via intramuscular or subcutaneous routes. The drug product can be used for the treatment or prophylaxis of infection by HIV or for the treatment, prophylaxis, or delay in the onset of AIDS (acquired immunodeficiency syndrome) or ARC (AIDS related complex).

Abstract: The present invention relates to a compound exhibiting Giant Magneto-Impedance (GMI) properties. The general chemical formula of the compound is (FeXCo100-X)100-(?+?+?)Cr?Si?B?, characterized in that ?<? and ?<?, wherein ? is preferably in the range of 2 to 4% by weight, ? is preferably in the range of 11.5% to 13% by weight, and ? is preferably in the range of 11% to 13% by weight, and X is preferably about 6% by weight. The chemical formula more preferably is (Fe6%Co94%)72.5%Cr2% Si12.5%B13%. The present invention also relates to a giant magneto-impedance (GMI) based sensing device for non-destructive contactless detection of carburization in austenitic stainless steel samples in field.

Abstract: The present invention relates to a compound exhibiting Giant Magneto-Impedance (GMI) properties. The general chemical formula of the compound is (FeXCo100-X)100-(?+?+?)Cr?Si?B?, characterized in that ?<? and ?<?, wherein ? is preferably in the range of 2 to 4% by weight, ? is preferably in the range of 11.5% to 13% by weight, and ? is preferably in the range of 11% to 13% by weight, and X is preferably about 6% by weight. The chemical formula more preferably is (Fe6%Co94%)72.5%Cr2% Si12.5%B13%. The present invention also relates to a giant magneto-impedance (GMI) based sensing device for non-destructive contactless detection of carburization in austenitic stainless steel samples in field.

Abstract: It is well documented that transgenes with inverted repeats can efficiently trigger post-transcriptional gene silencing (PTGS), presumably via a double stranded RNA induced by complementary sequences in their transcripts. We show here that transgenes with intrinsic direct repeats can also induce PTGS at a very high frequency (80-100%). A transgene with three or four repeats induced PTGS in almost 100% of the primary transformants, regardless of whether a strong (enhanced 35S promoter) or a relatively weak (chlorophyll a/b binding protein promoter) promoter was used. The PTGS induced by three or four repeats is consistently inherited in subsequent generations, and can inactivate homologous genes in trans. Based on the high frequency and consistent heritability, we propose that the intrinsic direct repeat within a transgene may act as a primary determinant of PTGS referred to as direct repeat-induced PTGS (driPTGS).

Abstract: The invention is directed to novel promoters or mutants thereof from Chlorella virus DNA methyltansferase genes. A Chlorella virus gene promoter is operably linked to a first and/or second DNA sequence encoding a gene that is different from the Chlorella virus to form an expression cassette. An expression cassette can be introduced into prokaryotic and/or eukaryotic cells and can provide for a high level of expression of the gene encoded by the first and/or second DNA sequence. The invention also provides a method for screening other Chlorella virus genes for promoters that can function to express a heterologous gene in prokaryotic and/or eukaryotic hosts.

Abstract: The present invention relate to a device for the non-destructive evaluation of such structures and components as are in service and which are intended to continue in use for an extended period during which time a number of defects such as residual stress, fatigue, creep or the formation of magnetic phase in non-ferromagnetic steel can develop; in addition to its primary purpose of detecting and/or determining the stated defects in-service steel structures or components, the device of the present invention also possesses the advantage that it can be applied for the sorting and classification of steels of different compositions according to the results of defects detected.

Abstract: The present, the invention relates to a device for the non-destructive evaluation of such structures and components as are in service and which are intended to continue in use for an extended period during which time a number of defects such as residual stress, fatigue, creep or the formation of magnetic phase in non-ferromagnetic steel can develop; in addition to its primary purpose of detecting and/or determining the stated defects in in-service steel structures or components, the device of the present invention also possesses the advantage that it can be applied for the sorting and classification of steels of different compositions according to the results of defects detected.

Abstract: The invention is directed to novel promoters or mutants thereof from Chlorella virus DNA methyltransferase genes. A Chlorella virus gene promoter is operably linked to a first and/or second DNA sequence encoding a gene that is different from the Chlorella virus gene to form an expression cassette. An expression cassette can be introduced into prokaryotic and/or eukaryotic cells and can provide for a high level of expression of the gene encoded by the first and/or second DNA sequence. The invention also provides a method for screening other Chlorella virus genes for promoters that can function to express a heterologous gene in prokaryotic and/or eukaryotic hosts.

Abstract: Novel transgenic plants having the ability to express a functional 2-5A system, i.e., a 2-5A synthetase which produces 5'-phosphorylated, 2',5'-linked oligoadenylates (2-5A) in response to double stranded RNA (dsRNA), and a 2-5A-dependent (RNase L), are disclosed. The novel transgenic plants expressing the functional 2-5A system, such as novel transgenic tobacco plants, are immune to and resistant against viral infection. When the novel transgenic tobacco plants are exposed to three different types of plant viruses, i.e., TMV, TEV and AIMV, such viral exposure leads to necrotic local lesions in such transgenic tobacco plants instead of typical systemic infections.

Abstract: The invention is directed to novel promoters or mutants thereof from Chlorella virus DNA methyltransferase genes. A Chlorella virus gene promoter is operably linked to a first and/or second DNA sequence encoding a gene that is different from the Chlorella virus gene to form an expression cassette. An expression cassette can be introduced into prokaryotic and/or eukaryotic cells and can provide for a high level of expression of the gene encoded by the first and/or second DNA sequence. The invention also provides a method for screening other Chlorella virus genes for promoters that can function to express a heterologous gene in prokaryotic and/or eukaryotic hosts.