Abstract: A method for predicting responsiveness to a HER2-directed therapy by assessing HER2 heterogeneity in a tumor includes contacting a sample of the tumor with a biomarker-specific reagent that specifically binds to HER2 protein and detecting HER2 protein in the sample, contacting the sample of the tumor with a first nucleic acid probe that specifically binds HER2 genomic DNA and detecting HER2 gene amplification status in the sample, contacting the sample of the tumor with a second nucleic acid probe that specifically binds HER2 RNA and detecting HER2 RNA status in the sample scoring the HER2 protein (IHC), HER2 gene (DISH), and HER2 RNA (RNA-ISH), predicting that the tumor is responsive to the HER2-directed therapy if the tumor reveals a first foci having a first score and a second score, in which the first score and the second score are not the same.

Abstract: An aerial vehicle including a collapsible and inflatable vehicle body capable of being filled with a lighter than air gas so as to make the vehicle semi-buoyant or 100% buoyant at a predetermined altitude in an atmosphere above a solar system body. The vehicle body has a shape suitable to provide aerodynamic lift. The vehicle may include a propulsion device coupled to and extending from the vehicle body, where the device provides power to aerodynamically lift the vehicle above the 100% buoyant altitude to a higher altitude where the vehicle can maintain that altitude through the aerodynamic lift and vehicle buoyancy. The vehicle is configured to be deployed/inflated from a collapsed and stowed configuration to a deployed/inflated configuration in an orbit above the atmosphere of the solar system body, and is configured to enter the atmosphere in the inflated configuration and descend without propulsion.

Abstract: Chromatic correction of a Fresnel lens is effected by collecting data at multiple detectors arrayed along the optical axis of the lens and then digitally processing data from each detector to obtain multiple sets of image data corresponding to selected tuned wavelengths associated with the multiple detectors, or to obtain composite multi-color image data. Digital processing includes deconvolving data from each detector with a point spread function (PSF) associated with the tuned wavelength of the detector, and thereby enhancing the image derived from the detector. Two possible techniques are also disclosed for deriving sub-band signal data having a wavelength that falls between the tuned wavelengths of adjacent detectors.