Patents by Inventor Amy S. Morgan

Amy S. Morgan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metabolic effects of certain glutathione analogs
    Patent number: 5955432
    Abstract: Compounds of the formula ##STR1## and the esters, amides, amide/esters and salts thereof, wherein YCO is .gamma.-glu or .beta.-asp;G* is phenylglycine or glycine;Z is CH.sub.2, O or S; andX is a hydrocarbon radical selected from C.sub.6 -C.sub.8 alkyl or selected aromatic groupsare useful in modulating hematopoiesis in bone marrow, mitigating the bone-marrow-destructive effects of a chemotherapeutic agent, and in potentiating the toxicity of chemotherapeutic agents.
    Type: Grant
    Filed: July 3, 1996
    Date of Patent: September 21, 1999
    Assignee: Terrapin Technologies, Inc.
    Inventors: Lawrence M. Kauvar, Amy S. Morgan, Matthew H. Lyttle, Richard F. Borch
  • Target-selective protocols based on mimics
    Patent number: 5786336
    Abstract: A method to potentiate the effect of a chemotherapeutic agent in a tumor cell, which method comprises administering to said tumor cell, along with said chemotherapeutic agent, a potentiating amount of a compound of the formula: ##STR1## or an amide, ester or hybrid amide/ester thereof, wherein X is a hydrocarbon radical optionally substituted on any aromatic moiety contained therein; Y--CO is .gamma.-Glu or .beta.-Asp and AA.sub.C is an amino acid, preferably glycine, phenylglycine, .beta.-alanine, alanine or phenylalanine is disclosed.Similar compounds can also be used to selectively exert cytotoxicity versus target cells as compared to nontarget cells and also to elevate the production of GM progenitors in bone marrow of mammalian subjects.
    Type: Grant
    Filed: September 19, 1994
    Date of Patent: July 28, 1998
    Assignee: Terrapin Technologies, Inc.
    Inventors: Lawrence M. Kauvar, Matthew H. Lyttle, Amy S. Morgan, Richard F. Borch
  • Bone marrow stimulation by certain glutathione analogs
    Patent number: 5767086
    Abstract: Compounds of the formula ##STR1## and the esters, amides, amide/esters and salts thereof, wherein YCO is .gamma.-glu or .beta.-asp;G* is phenyl glycine or glycine;Z is CH.sub.2, O or S; andX is a hydrocarbon radical of 1-20 C;are useful in stimulating the differentiation of bone marrow, mitigating the bone-marrow-destructive effects of a chemotherapeutic agent, and in potentiating the toxicity of chemotherapeutic agents.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 16, 1998
    Assignee: Terrapin Technologies, Inc.
    Inventors: Lawrence M. Kauvar, Matthew H. Lyttle, Amy S. Morgan, Richard F. Borch