Abstract: A compound composition for improving bone health and preparation and application thereof are provided. The compound composition is prepared by combining a traditional Chinese medicine extract with chicken cartilage collagen, magnesium, vitamin K2 and vitamin D3. The compound composition overcomes the food safety risk of the existing osteoporosis preventive drugs by adding the traditional Chinese medicine extract for improving osteoporosis and promoting bone health. And the compound composition disclosed can be used as a dietary supplement or health food raw material for preventing or treating osteoporosis. Therefore, the compound composition disclosed is suitable for promotion and application.

Abstract: The present invention relates to imidazo-pyridinyl compounds, or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject.

Abstract: An array substrate, a display panel, a display apparatus, and a method for manufacturing the array substrate are provided. The array substrate includes: a base substrate; a plurality of pixels, at least one of the pixels including a pixel driver circuit and a light-emitting unit electrically connected to the pixel driver circuit; a fingerprint recognition structure including a first capacitor electrode configured to form a capacitor for fingerprint recognition between at least a part of a touch body and the first capacitor electrode in response to the at least a part of the touch body covering the first capacitor electrode. The fingerprint recognition structure is in the at least one pixel, the pixel driver circuit includes a thin film transistor including an active layer and a gate, and the first capacitor electrode is in the same layer as one of the active layer or the gate of the thin film transistor.

Abstract: A display panel has a display region and at least one bonding region located beside the display region. The display panel includes: a base; and a plurality of conductive pads provided on the base and located in each bonding region. The plurality of conductive pads are arranged at intervals along a first direction. The plurality of conductive pads include at least one first type of conductive pad configured to transmit a direct current voltage signal to the display region and a plurality of second type of conductive pads configured to transmit a pulse voltage signal to the display region. A dimension of one first type of conductive pad in the first direction is greater than a dimension of one second type of conductive pad in the first direction.

Abstract: Three-dimensional (3D) NAND memory devices and methods are provided. In one aspect, a 3D NAND memory device includes a substrate, core regions, isolation regions, a layer stack, channel structures, and an isolation structure. Each core region is surrounded by one or more of the isolation regions. The layer stack is formed in each core region and includes first dielectric layers and conductor layers that are alternatingly stacked over each other. The channel structures are formed through the layer stack. The isolation structure is formed in one or more of the isolation regions, and includes second dielectric layers and third dielectric layers that are alternatingly stacked over each other.

Abstract: The present disclosure relates to a self-adaptive guided advanced driver assistance system (ADAS) considering a driving skill difference between drivers, including a driving skill classification module, configured to calculate a vehicle stability margin based on a vehicle state, and obtain a corresponding driving skill classification result with the vehicle stability margin and a driver state as inputs of a driving skill classification model; a skill learning range classification module, configured to obtain the vehicle stability margin and a distance between a vehicle and a lane line boundary, and use a skill learning range classification model to obtain a skill learning range classification result; and a self-adaptive guided driving right allocation module, configured to realize driving right allocation control based on the driving skill classification result and the skill learning range classification result, and generate an assisted steering torque acting on a vehicle steering system.

Abstract: The present disclosure relates to a semiconductor device and a method of fabricating the same, which includes a substrate, a plurality of bit lines, a plurality of first plugs, a first spacer, a second spacer, a plurality of second plugs and a metal silicide layer. The bit lines are disposed on the substrate. The first plugs are disposed on the substrate and separated from the bit lines. The first spacer and the second spacer are disposed between each of the bit lines and the first plugs, and include a first height and a second height respectively. The second plugs are disposed on the first plugs respectively, and the metal silicide layer is disposed between the first plugs and the second plugs, wherein an end surface of the metal silicide layer is clamped between the second spacer and the first spacer.

Abstract: A fluid-induced vibration energy harvesting apparatus with a non-rotating bluff body is provided. The apparatus does not use a common design method of rigidly securing a bluff body to an elastic beam in a design of the bluff body, but adopts a manner of connecting the bluff body and the elastic beam through a rotating shaft and a connecting shaft. Because a kinematic pair at a connection position is a rotating pair, the bluff body will only vibrate transversely and will not rotate, thereby achieving an effect of increasing an amplitude at the same frequency, and finally realizing an increase of converted electric energy and improving the conversion efficiency.

Abstract: Charge leakage/injection suppression circuitry within a capacitive programmable gain amplifier provides a low-impedance expulsion path for residual carriers within a feedback-path amplifier-mode switch and equalizes a voltage across a critical-leakage-path component of that amplifier-mode switch, reducing charge injection and leakage into an otherwise isolated amplifier input node to yield a low-noise amplifier output.

Abstract: A digital to analog converter (DAC) includes an amplifier including a buffer of the DAC, and a resistor ladder arrangement coupled to a non-inverting input terminal of the amplifier to generate a voltage based on a digital control word. The arrangement includes a first, least-significant bit, segment arranged in one of an R-2R or unit-R configuration, a second, most-significant bit, segment including one or more units each including a second-segment-resistor having a resistor terminal coupled to a respective second switch and having a second resistance, RMSB, and a third segment including one or more third-segment-resistors coupled in parallel to the non-inverting input terminal and connected to a first reference voltage terminal. M2 designates a number of bits in the digital control word for controlling the second switches, and the third segment has a total resistance, Rsp, based on M2.

Abstract: The present invention relates to an ethanol foam sclerosing agent for vascular anomalies and a preparation method thereof. The ethanol foam sclerosing agent includes absolute ethanol, water, Tween 80 and a stabilizer. The ethanol foam sclerosing agent further includes hyaluronic acid. The mass composition of the ethanol foam sclerosing agent includes 32-42% of absolute ethanol, 0.5-2% of Tween 80, 0-25% (excluding 0) of egg yolk lecithin, 0-2% (excluding 0) of hyaluronic acid, and the balance of water. The stabilizer is hyaluronic acid or glycerin. Foam is prepared by the Tessari method. While the original therapeutic effect of ethanol is not changed, the side effect of the ethanol is significantly reduced.

Abstract: The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins comprising the modified biotin-binding protein and an antigen. The disclosure further provides non-hemolytic variants of alpha-hemolysin from S. aureus and fusion protein comprising non-hemolytic variant of alpha-hemolysin and a biotin-binding domains. Immunogenic compositions comprising the proteins are also disclosed and use of such immunogenic compositions for inducing an immune response or for vaccinating a subject are also disclosed.

Abstract: A server device which is self-adaptive to different placements and locations includes a chassis, a plurality of storage elements, and a storage cabinet. First and third slide rails are positioned at opposite sides of the storage cabinet along a first direction. Second and fourth slide rails are positioned at other two opposing sides of the storage cabinet. The storage cabinet is movably positioned in the chassis along a third direction. When the chassis is horizontal, the first slide rail and the third slide rail provide support for the storage cabinet and when the chassis is vertical, support is provided by the second and fourth slide rails. The problem of the storage cabinet being difficult to slide when the placement of the chassis is changed is reduced, and the server device is more flexible in its placement.

Abstract: The present disclosure provides isolated monoclonal antibodies or an antigen-binding portion thereof that specifically bind to CD40 preferably human CD40 with high affinity, and that function as CD40 agonists. The disclosed invention also relates to antibodies that are chimeric, humanized, bispecific, derivatized, single chain antibodies or portions of fusion proteins. Nucleic acid molecules encoding the antibodies of the disclosed invention, hybridoma, and methods for expressing the antibodies of the disclosed invention are also provided. Pharmaceutical compositions comprising the antibodies of the disclosed invention are also provided. This disclosure also provides methods for regulating humoral and cellular immune responses, as well as methods for treating cancer using an anti-CD40 agonist antibody of the disclosed invention.